The Effect of Tacrine (THA) on Cycloheximide-and Basal Forebrain Lesion-Induced Memory Deficit in Rats

Toshitaka Nabeshima, Eiko Maruyama, Akira Katoh, Tsutomu Kameyama

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21 Citations (Scopus)

Abstract

The effects of 9-amino-1,2,3,4-tetrahydroacridine (tacrine), an active acetylcholinesterase inhibitor, on cyclohcximide- and basal forebrain (BF) lesion-induced memory deficit in the water maze and passive avoidance task were investigated. While cycloheximide (1.5 mg/kg, s.c.) produced amnesia in the passive avoidance task, chronic administration of tacrine (1, 3 and 10 mg/kg, once a day for 1 week) improved the amnesia. BF lesion produced amnesia in both the water maze and passive avoidance tasks. Chronic tacrine (0.1-3 mg/kg, passive avoidance task, or 0.3 mg/kg, water maze task, once a day for 1 week) improved BF lesion-induced amnesia in the passive avoidance and water maze tasks. These results suggest that tacrine may be useful for senile dementia.

Original languageEnglish
Pages (from-to)311-319
Number of pages9
JournalThe Japanese Journal of Pharmacology
Volume57
Issue number3
DOIs
Publication statusPublished - 01-1991

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All Science Journal Classification (ASJC) codes

  • Pharmacology

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