The effects of calcium antagonists and prostaglandin El on isolated canine coronary arterial tension

Katsuhiko Yoshida, Jinichi Iwase, Fumihiko Murakami, Akihiko Usui, Michiaki Hibi, Mitsuo Kawamura

Research output: Contribution to journalArticlepeer-review

Abstract

The effects of calcium antagonists (nifedipine, nicardipine, diltiazem, and verapamil) and prostaglandin E1 (PGE1) on the tension of isolated canine coronary arterial strips were studies. In a solution containing 20 mEq/L of K+, 127 mEq/L of Na+, the tension was increased by 500-1,000 mg with 4 mEq/L of Ca2+. This increase in tension was suppressed by Ca-antagonists and PGE1 dose-dependently. Nifedipine 10-5M, nicardipine 3 X 10-7M, diltiazem 3 X 10-6M, and verapamil 3 X 10-6M completely suppressed the increased tension. The maximal suppression of the tension produced by PGE1 was about 40% at 10-10M. In 20 mEq/L K+ solution (0 mEq/L Ca2+, 37°C), the reduction of the Na+ concentrations from 127 mEq/L to 12 mEq/L increased the tension by 50 to 100 mg. This increase in tension was not suppressed by Ca-antagonists or PGEI. In conclusion, this study demonstrated that Ca-antagonists and PGE1 suppressed an increase in the tension caused by Ca2+ but did not suppress an increase in the tension caused by Na+ reduction.

Original languageEnglish
Pages (from-to)1073-1077
Number of pages5
JournalSurgery Today
Volume24
Issue number12
DOIs
Publication statusPublished - 12-1994
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Surgery

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