TY - JOUR
T1 - The effects of calcium antagonists and prostaglandin El on isolated canine coronary arterial tension
AU - Yoshida, Katsuhiko
AU - Iwase, Jinichi
AU - Murakami, Fumihiko
AU - Usui, Akihiko
AU - Hibi, Michiaki
AU - Kawamura, Mitsuo
PY - 1994/12
Y1 - 1994/12
N2 - The effects of calcium antagonists (nifedipine, nicardipine, diltiazem, and verapamil) and prostaglandin E1 (PGE1) on the tension of isolated canine coronary arterial strips were studies. In a solution containing 20 mEq/L of K+, 127 mEq/L of Na+, the tension was increased by 500-1,000 mg with 4 mEq/L of Ca2+. This increase in tension was suppressed by Ca-antagonists and PGE1 dose-dependently. Nifedipine 10-5M, nicardipine 3 X 10-7M, diltiazem 3 X 10-6M, and verapamil 3 X 10-6M completely suppressed the increased tension. The maximal suppression of the tension produced by PGE1 was about 40% at 10-10M. In 20 mEq/L K+ solution (0 mEq/L Ca2+, 37°C), the reduction of the Na+ concentrations from 127 mEq/L to 12 mEq/L increased the tension by 50 to 100 mg. This increase in tension was not suppressed by Ca-antagonists or PGEI. In conclusion, this study demonstrated that Ca-antagonists and PGE1 suppressed an increase in the tension caused by Ca2+ but did not suppress an increase in the tension caused by Na+ reduction.
AB - The effects of calcium antagonists (nifedipine, nicardipine, diltiazem, and verapamil) and prostaglandin E1 (PGE1) on the tension of isolated canine coronary arterial strips were studies. In a solution containing 20 mEq/L of K+, 127 mEq/L of Na+, the tension was increased by 500-1,000 mg with 4 mEq/L of Ca2+. This increase in tension was suppressed by Ca-antagonists and PGE1 dose-dependently. Nifedipine 10-5M, nicardipine 3 X 10-7M, diltiazem 3 X 10-6M, and verapamil 3 X 10-6M completely suppressed the increased tension. The maximal suppression of the tension produced by PGE1 was about 40% at 10-10M. In 20 mEq/L K+ solution (0 mEq/L Ca2+, 37°C), the reduction of the Na+ concentrations from 127 mEq/L to 12 mEq/L increased the tension by 50 to 100 mg. This increase in tension was not suppressed by Ca-antagonists or PGEI. In conclusion, this study demonstrated that Ca-antagonists and PGE1 suppressed an increase in the tension caused by Ca2+ but did not suppress an increase in the tension caused by Na+ reduction.
UR - https://www.scopus.com/pages/publications/0028580274
UR - https://www.scopus.com/inward/citedby.url?scp=0028580274&partnerID=8YFLogxK
U2 - 10.1007/BF01367458
DO - 10.1007/BF01367458
M3 - Article
C2 - 7780229
AN - SCOPUS:0028580274
SN - 0941-1291
VL - 24
SP - 1073
EP - 1077
JO - Surgery Today
JF - Surgery Today
IS - 12
ER -