The effects of different periods of co-administration of oral and long-acting injectable aripiprazole

A propensity score analysis

Masakazu Hatano, Hiroyuki Kamei, Ippei Takeuchi, Kaori Tozawa, Shinya Makino, Manako Hanya, Shigeki Yamada, Nakao Iwata

Research output: Contribution to journalArticle

Abstract

Objective: Long-acting injectable (LAI) aripiprazole is recommended to be combined with oral aripiprazole for 2 weeks after its introduction. However, we often experience patients who require more than 2 weeks of combined use. Therefore, differences in combination periods need to be examined. Methods: This was a case–control study. We surveyed prescription profiles for oral aripiprazole administration in conjunction with LAI aripiprazole introduction and assessed the clinical course during a 12-week follow-up period. Results: Among 121 patients, 58 (47.9%) were administered both oral and LAI aripiprazole for more than 2 weeks. Although there was no significant difference in treatment failure (defined as psychiatric hospitalization or discontinuation of LAI aripiprazole from any cause) between the two groups, the group that was administered oral aripiprazole for more than 2 weeks received less additional benzodiazepines compared with that of the 2 weeks group (adjusted odds ratio, 0.055; 95% confidence interval [0.0060, 0.50]; p < 0.01). Conclusions: Our data support a flexible co-administration period for oral and LAI aripiprazole in consideration of the pharmacokinetics, but further studies are needed.

Original languageEnglish
Article numbere2681
JournalHuman Psychopharmacology
Volume34
Issue number1
DOIs
Publication statusPublished - 01-01-2019

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Propensity Score
Oral Administration
Injections
Aripiprazole
Treatment Failure
Benzodiazepines
Prescriptions
Psychiatry
Hospitalization
Pharmacokinetics
Odds Ratio
Confidence Intervals

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Pharmacology (medical)

Cite this

Hatano, Masakazu ; Kamei, Hiroyuki ; Takeuchi, Ippei ; Tozawa, Kaori ; Makino, Shinya ; Hanya, Manako ; Yamada, Shigeki ; Iwata, Nakao. / The effects of different periods of co-administration of oral and long-acting injectable aripiprazole : A propensity score analysis. In: Human Psychopharmacology. 2019 ; Vol. 34, No. 1.
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The effects of different periods of co-administration of oral and long-acting injectable aripiprazole : A propensity score analysis. / Hatano, Masakazu; Kamei, Hiroyuki; Takeuchi, Ippei; Tozawa, Kaori; Makino, Shinya; Hanya, Manako; Yamada, Shigeki; Iwata, Nakao.

In: Human Psychopharmacology, Vol. 34, No. 1, e2681, 01.01.2019.

Research output: Contribution to journalArticle

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AU - Tozawa, Kaori

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