The effects of oral melatonin on the autonomic function in healthy subjects

Tsuyoshi Kitajima, Takashi Kanbayashi, Yasushi Saitoh, Yuriko Ogawa, Tomonari Sugiyama, Yoshihiko Kaneko, Yoshiko Sasaki, Rika Aizawa, Tetsuo Shimisu

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)


We investigated the influence of melatonin on the human autonomic functions by measuring muscle sympathetic nerve activity (MSNA). Five healthy male volunteers took 3 mg of melatonin, and their plasma melatonin concentration, blood pressure, heart rate, and burst rate of MSNA were then recorded. The peak level of melatonin concentration showed a marked interindividual variation. Blood pressure was reduced significantly, while heart rate and burst rate of MSNA did not change significantly. These results indicate that melatonin has a hypotensive effect on blood pressure, and the central cardiovascular regulatory mechanism such as lowering of the baroreflex setpoint would be involved in the effect.

Original languageEnglish
Pages (from-to)299-300
Number of pages2
JournalPsychiatry and clinical neurosciences
Issue number3
Publication statusPublished - 2001
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Neuroscience
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health


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