The effects of oral melatonin on the autonomic function in healthy subjects

Tsuyoshi Kitajima; Takashi Kanbayashi; Yasushi Saitoh; Yuriko Ogawa; Tomonari Sugiyama; Yoshihiko Kaneko; Yoshiko Sasaki; Rika Aizawa; Tetsuo Shimisu

doi:10.1046/j.1440-1819.2001.00866.x

The effects of oral melatonin on the autonomic function in healthy subjects

Tsuyoshi Kitajima
, Takashi Kanbayashi
, Yasushi Saitoh
, Yuriko Ogawa
, Tomonari Sugiyama
, Yoshihiko Kaneko
, Yoshiko Sasaki
, Rika Aizawa
, Tetsuo Shimisu

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

We investigated the influence of melatonin on the human autonomic functions by measuring muscle sympathetic nerve activity (MSNA). Five healthy male volunteers took 3 mg of melatonin, and their plasma melatonin concentration, blood pressure, heart rate, and burst rate of MSNA were then recorded. The peak level of melatonin concentration showed a marked interindividual variation. Blood pressure was reduced significantly, while heart rate and burst rate of MSNA did not change significantly. These results indicate that melatonin has a hypotensive effect on blood pressure, and the central cardiovascular regulatory mechanism such as lowering of the baroreflex setpoint would be involved in the effect.

Original language	English
Pages (from-to)	299-300
Number of pages	2
Journal	Psychiatry and Clinical Neurosciences
Volume	55
Issue number	3
DOIs	https://doi.org/10.1046/j.1440-1819.2001.00866.x
Publication status	Published - 2001
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

General Neuroscience
Neurology
Clinical Neurology
Psychiatry and Mental health

Access to Document

10.1046/j.1440-1819.2001.00866.x

Cite this

@article{14b4b862f97f4662a113941841c48a69,

title = "The effects of oral melatonin on the autonomic function in healthy subjects",

abstract = "We investigated the influence of melatonin on the human autonomic functions by measuring muscle sympathetic nerve activity (MSNA). Five healthy male volunteers took 3 mg of melatonin, and their plasma melatonin concentration, blood pressure, heart rate, and burst rate of MSNA were then recorded. The peak level of melatonin concentration showed a marked interindividual variation. Blood pressure was reduced significantly, while heart rate and burst rate of MSNA did not change significantly. These results indicate that melatonin has a hypotensive effect on blood pressure, and the central cardiovascular regulatory mechanism such as lowering of the baroreflex setpoint would be involved in the effect.",

author = "Tsuyoshi Kitajima and Takashi Kanbayashi and Yasushi Saitoh and Yuriko Ogawa and Tomonari Sugiyama and Yoshihiko Kaneko and Yoshiko Sasaki and Rika Aizawa and Tetsuo Shimisu",

year = "2001",

doi = "10.1046/j.1440-1819.2001.00866.x",

language = "English",

volume = "55",

pages = "299--300",

journal = "Psychiatry and Clinical Neurosciences",

issn = "1323-1316",

publisher = "Wiley-Blackwell",

number = "3",

}

TY - JOUR

T1 - The effects of oral melatonin on the autonomic function in healthy subjects

AU - Kitajima, Tsuyoshi

AU - Kanbayashi, Takashi

AU - Saitoh, Yasushi

AU - Ogawa, Yuriko

AU - Sugiyama, Tomonari

AU - Kaneko, Yoshihiko

AU - Sasaki, Yoshiko

AU - Aizawa, Rika

AU - Shimisu, Tetsuo

PY - 2001

Y1 - 2001

N2 - We investigated the influence of melatonin on the human autonomic functions by measuring muscle sympathetic nerve activity (MSNA). Five healthy male volunteers took 3 mg of melatonin, and their plasma melatonin concentration, blood pressure, heart rate, and burst rate of MSNA were then recorded. The peak level of melatonin concentration showed a marked interindividual variation. Blood pressure was reduced significantly, while heart rate and burst rate of MSNA did not change significantly. These results indicate that melatonin has a hypotensive effect on blood pressure, and the central cardiovascular regulatory mechanism such as lowering of the baroreflex setpoint would be involved in the effect.

AB - We investigated the influence of melatonin on the human autonomic functions by measuring muscle sympathetic nerve activity (MSNA). Five healthy male volunteers took 3 mg of melatonin, and their plasma melatonin concentration, blood pressure, heart rate, and burst rate of MSNA were then recorded. The peak level of melatonin concentration showed a marked interindividual variation. Blood pressure was reduced significantly, while heart rate and burst rate of MSNA did not change significantly. These results indicate that melatonin has a hypotensive effect on blood pressure, and the central cardiovascular regulatory mechanism such as lowering of the baroreflex setpoint would be involved in the effect.

UR - https://www.scopus.com/pages/publications/0034989654

UR - https://www.scopus.com/pages/publications/0034989654#tab=citedBy

U2 - 10.1046/j.1440-1819.2001.00866.x

DO - 10.1046/j.1440-1819.2001.00866.x

M3 - Article

C2 - 11422882

AN - SCOPUS:0034989654

SN - 1323-1316

VL - 55

SP - 299

EP - 300

JO - Psychiatry and Clinical Neurosciences

JF - Psychiatry and Clinical Neurosciences

IS - 3

ER -

The effects of oral melatonin on the autonomic function in healthy subjects

Abstract

UN SDGs

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this