The effects of prostaglandin E1 and tyrosine kinase inhibitors on energy status and protein synthetic ability in hepatic ischemia-reperfusion injury

Toshio Nakagohri, Takehide Asano, Takeshi Uematsu, Takashi Kenmochi, Toru Kubota, Osamu Kainuma, Kaichi Isono

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The effects of prostaglandin E1 (PGE1) and tyrosine kinase inhibitors on hepatic energy status and protein synthesis in ischemic livers were studied using 31P-magnetic resonance spectroscopy in a rat model. The continuous administration of PGE1 significantly increased the β-adenosine triphosphate/inorganic phosphate (β-ATP/P1) ratio and hepatic protein synthesis rate (HPS) after ischemia-reperfusion injury. Microscopic examination showed that the continuous administration of PGE1 inhibited the development of sinusoidal hemorrhage and edema. Thus, it was concluded that PGE1 has a beneficial effect on ischemia-reperfusion injury in the liver. Pretreatment with tyrosine kinase inhibitor also increased the β-ATP/P1 ratio; however, when tyrosine kinase inhibitor was injected before ischemia, the HPS became significantly reduced. Based on these data, the protective effect of tyrosine kinase inhibitor is unconvincing.

Original languageEnglish
Pages (from-to)517-521
Number of pages5
JournalSurgery Today
Volume28
Issue number5
DOIs
Publication statusPublished - 25-05-1998

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Alprostadil
Reperfusion Injury
Protein-Tyrosine Kinases
Liver
Adenosine Triphosphate
Proteins
Edema
Magnetic Resonance Spectroscopy
Ischemia
Phosphates
Hemorrhage

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Nakagohri, Toshio ; Asano, Takehide ; Uematsu, Takeshi ; Kenmochi, Takashi ; Kubota, Toru ; Kainuma, Osamu ; Isono, Kaichi. / The effects of prostaglandin E1 and tyrosine kinase inhibitors on energy status and protein synthetic ability in hepatic ischemia-reperfusion injury. In: Surgery Today. 1998 ; Vol. 28, No. 5. pp. 517-521.
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The effects of prostaglandin E1 and tyrosine kinase inhibitors on energy status and protein synthetic ability in hepatic ischemia-reperfusion injury. / Nakagohri, Toshio; Asano, Takehide; Uematsu, Takeshi; Kenmochi, Takashi; Kubota, Toru; Kainuma, Osamu; Isono, Kaichi.

In: Surgery Today, Vol. 28, No. 5, 25.05.1998, p. 517-521.

Research output: Contribution to journalArticle

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AU - Nakagohri, Toshio

AU - Asano, Takehide

AU - Uematsu, Takeshi

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AU - Kubota, Toru

AU - Kainuma, Osamu

AU - Isono, Kaichi

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