Abstract
One sarin-like and one soman-like organophosphorus agent [bis(isopropyl methyl)phosphonate, BIMP and bis(pinacolyl methyl)phosphonate, BPMP] were injected intravenously (iv) in rats. An increase in the tyrosine phosphorylation of several proteins in the cytosol fraction of the brain was observed. Activation of c-Jun N-terminal kinase (JNK) and slight activation of mitogen-activated protein kinase (MAPK) in the cytosol were also observed. The activation of these enzymes may be related to the high toxicity of these nerve agents. (C) 2000 Elsevier Science Ireland Ltd.
Original language | English |
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Pages (from-to) | 171-178 |
Number of pages | 8 |
Journal | Forensic science international |
Volume | 112 |
Issue number | 2-3 |
DOIs | |
Publication status | Published - 14-08-2000 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Pathology and Forensic Medicine