The effects of sarin-like and soman-like organophosphorus agents on MAPK and JNK in rat brains

Hitoshi Niijima, Masataka Nagao, Makoto Nakajima, Takehiko Takatori, Mineo Iwasa, Yoshitaka Maeno, Hiroyoshi Koyama, Ichiro Isobe

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

One sarin-like and one soman-like organophosphorus agent [bis(isopropyl methyl)phosphonate, BIMP and bis(pinacolyl methyl)phosphonate, BPMP] were injected intravenously (iv) in rats. An increase in the tyrosine phosphorylation of several proteins in the cytosol fraction of the brain was observed. Activation of c-Jun N-terminal kinase (JNK) and slight activation of mitogen-activated protein kinase (MAPK) in the cytosol were also observed. The activation of these enzymes may be related to the high toxicity of these nerve agents. (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)171-178
Number of pages8
JournalForensic science international
Volume112
Issue number2-3
DOIs
Publication statusPublished - 14-08-2000
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

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