TY - JOUR
T1 - The efficacy of the administration of recombinant human soluble thrombomodulin in patients with DIC
AU - Aota, Takumi
AU - Wada, Hideo
AU - Yamashita, Yoshiki
AU - Matsumoto, Takeshi
AU - Ohishi, Kohshi
AU - Suzuki, Kei
AU - Imai, Hiroshi
AU - Usui, Masanobu
AU - Isaji, Shuji
AU - Katayama, Naoyuki
N1 - Publisher Copyright:
© 2015, The Japanese Society of Hematology.
PY - 2016/2/1
Y1 - 2016/2/1
N2 - Efficacy of recombinant human soluble thrombomodulin (rhTM), which is frequently used to treat patients with disseminated intravascular coagulation (DIC), was compared with that of gabexate mesilate (GM), which was previously used routinely in the treatment of DIC patients in Japan. Although there was no significant difference in the resolution rates of the patients who were treated with rhTM and GM, the results of our analysis revealed that the mortality rate was significantly higher among infectious disease patients treated with GM than in those treated with rhTM. Levels of fibrinogen and fibrin degradation products (FDP), antithrombin (AT) activity, and thrombin AT complex (TAT) were significantly lower in the DIC patients with infectious diseases, while fibrinogen levels were high. FDP level, D-dimer, platelet count, PT ratio, and DIC score all showed significant improvement following rhTM treatment. There were no significant difference between survivors and non-survivors in terms of DIC score, FDP level, platelet count, AT activity, or in TAT, SF and PPIC levels before rhTM treatment. However, fibrinogen levels were significantly lower in non-survivors than in survivors. These results indicate that rhTM may be superior to GM for the treatment of DIC.
AB - Efficacy of recombinant human soluble thrombomodulin (rhTM), which is frequently used to treat patients with disseminated intravascular coagulation (DIC), was compared with that of gabexate mesilate (GM), which was previously used routinely in the treatment of DIC patients in Japan. Although there was no significant difference in the resolution rates of the patients who were treated with rhTM and GM, the results of our analysis revealed that the mortality rate was significantly higher among infectious disease patients treated with GM than in those treated with rhTM. Levels of fibrinogen and fibrin degradation products (FDP), antithrombin (AT) activity, and thrombin AT complex (TAT) were significantly lower in the DIC patients with infectious diseases, while fibrinogen levels were high. FDP level, D-dimer, platelet count, PT ratio, and DIC score all showed significant improvement following rhTM treatment. There were no significant difference between survivors and non-survivors in terms of DIC score, FDP level, platelet count, AT activity, or in TAT, SF and PPIC levels before rhTM treatment. However, fibrinogen levels were significantly lower in non-survivors than in survivors. These results indicate that rhTM may be superior to GM for the treatment of DIC.
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U2 - 10.1007/s12185-015-1899-5
DO - 10.1007/s12185-015-1899-5
M3 - Article
C2 - 26590919
AN - SCOPUS:84955722517
SN - 0925-5710
VL - 103
SP - 173
EP - 179
JO - International Journal of Hematology
JF - International Journal of Hematology
IS - 2
ER -