The Epstein-Barr virus BDLF4 gene is required for efficient expression of viral late lytic genes

Takahiro Watanabe, Yohei Narita, Masahiro Yoshida, Yoshitaka Sato, Fumi Goshima, Hiroshi Kimura, Takayuki Murata

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Epstein-Barr virus (EBV) is a gammaherpesvirus, associated with infectious mononucleosis and various types of malignancy. We focused here on the BDLF4 gene of EBV and identified it as a lytic gene, expressed with early kinetics. Viral late gene expression of the BDLF4 knockout strain was severely restricted; this could be restored by an exogenous supply of BDLF4. These results indicate that BDLF4 is important for the EBV lytic replication cycle, especially in late gene expression.

Original languageEnglish
Pages (from-to)10120-10124
Number of pages5
JournalJournal of Virology
Volume89
Issue number19
DOIs
Publication statusPublished - 01-01-2015

Fingerprint

Human herpesvirus 4
Human Herpesvirus 4
Genes
Gene Expression
gene expression
Infectious Mononucleosis
genes
Viral Genes
Virus Replication
kinetics
Neoplasms

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

Cite this

Watanabe, Takahiro ; Narita, Yohei ; Yoshida, Masahiro ; Sato, Yoshitaka ; Goshima, Fumi ; Kimura, Hiroshi ; Murata, Takayuki. / The Epstein-Barr virus BDLF4 gene is required for efficient expression of viral late lytic genes. In: Journal of Virology. 2015 ; Vol. 89, No. 19. pp. 10120-10124.
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Watanabe, T, Narita, Y, Yoshida, M, Sato, Y, Goshima, F, Kimura, H & Murata, T 2015, 'The Epstein-Barr virus BDLF4 gene is required for efficient expression of viral late lytic genes', Journal of Virology, vol. 89, no. 19, pp. 10120-10124. https://doi.org/10.1128/JVI.01604-15

The Epstein-Barr virus BDLF4 gene is required for efficient expression of viral late lytic genes. / Watanabe, Takahiro; Narita, Yohei; Yoshida, Masahiro; Sato, Yoshitaka; Goshima, Fumi; Kimura, Hiroshi; Murata, Takayuki.

In: Journal of Virology, Vol. 89, No. 19, 01.01.2015, p. 10120-10124.

Research output: Contribution to journalArticle

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AB - Epstein-Barr virus (EBV) is a gammaherpesvirus, associated with infectious mononucleosis and various types of malignancy. We focused here on the BDLF4 gene of EBV and identified it as a lytic gene, expressed with early kinetics. Viral late gene expression of the BDLF4 knockout strain was severely restricted; this could be restored by an exogenous supply of BDLF4. These results indicate that BDLF4 is important for the EBV lytic replication cycle, especially in late gene expression.

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Watanabe T, Narita Y, Yoshida M, Sato Y, Goshima F, Kimura H et al. The Epstein-Barr virus BDLF4 gene is required for efficient expression of viral late lytic genes. Journal of Virology. 2015 Jan 1;89(19):10120-10124. https://doi.org/10.1128/JVI.01604-15