The Epstein-Barr virus BDLF4 gene is required for efficient expression of viral late lytic genes

Takahiro Watanabe; Yohei Narita; Masahiro Yoshida; Yoshitaka Sato; Fumi Goshima; Hiroshi Kimura; Takayuki Murata

doi:10.1128/JVI.01604-15

The Epstein-Barr virus BDLF4 gene is required for efficient expression of viral late lytic genes

Takahiro Watanabe, Yohei Narita, Masahiro Yoshida, Yoshitaka Sato, Fumi Goshima, Hiroshi Kimura, Takayuki Murata

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

Epstein-Barr virus (EBV) is a gammaherpesvirus, associated with infectious mononucleosis and various types of malignancy. We focused here on the BDLF4 gene of EBV and identified it as a lytic gene, expressed with early kinetics. Viral late gene expression of the BDLF4 knockout strain was severely restricted; this could be restored by an exogenous supply of BDLF4. These results indicate that BDLF4 is important for the EBV lytic replication cycle, especially in late gene expression.

Original language	English
Pages (from-to)	10120-10124
Number of pages	5
Journal	Journal of Virology
Volume	89
Issue number	19
DOIs	https://doi.org/10.1128/JVI.01604-15
Publication status	Published - 2015
Externally published	Yes

All Science Journal Classification (ASJC) codes

Microbiology
Immunology
Insect Science
Virology

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abstract = "Epstein-Barr virus (EBV) is a gammaherpesvirus, associated with infectious mononucleosis and various types of malignancy. We focused here on the BDLF4 gene of EBV and identified it as a lytic gene, expressed with early kinetics. Viral late gene expression of the BDLF4 knockout strain was severely restricted; this could be restored by an exogenous supply of BDLF4. These results indicate that BDLF4 is important for the EBV lytic replication cycle, especially in late gene expression.",

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AU - Watanabe, Takahiro

AU - Narita, Yohei

AU - Yoshida, Masahiro

AU - Sato, Yoshitaka

AU - Goshima, Fumi

AU - Kimura, Hiroshi

AU - Murata, Takayuki

PY - 2015

Y1 - 2015

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AB - Epstein-Barr virus (EBV) is a gammaherpesvirus, associated with infectious mononucleosis and various types of malignancy. We focused here on the BDLF4 gene of EBV and identified it as a lytic gene, expressed with early kinetics. Viral late gene expression of the BDLF4 knockout strain was severely restricted; this could be restored by an exogenous supply of BDLF4. These results indicate that BDLF4 is important for the EBV lytic replication cycle, especially in late gene expression.

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The Epstein-Barr virus BDLF4 gene is required for efficient expression of viral late lytic genes

Abstract

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