The etiological role of allogeneic fetal rejection in pre-eclampsia

Haruki Nishizawa, Kiyoshi Hasegawa, Machiko Suzuki, Shingo Kamoshida, Takema Kato, Kuniaki Saito, Yutaka Tsutsumi, Hiroki Kurahashi, Yasuhiro Udagawa

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Problem: It has been demonstrated that allogeneic fetal rejection in normal pregnancy is prevented by placental indoleamine 2,3-dioxygenase (IDO). Further, an immunological etiology has been implicated in pre-eclampsia. Method of study: We examined the differences in placental IDO activity between normal and pre-eclamptic pregnancies. Results: IDO mRNA expression and enzyme activity levels in the placenta were low in patients with severe pre-eclampsia. The enzyme activity also inversely correlates with the blood pressure of the patients. In the placentas from severe pre-eclampsia, IDO immunoreactivity was low, whereas regional T-cell infiltration was observed reciprocally proportional to the IDO activity. Conclusion: Our findings implicate a potential role for IDO activity and a maternal immunological reaction against an allogeneic fetus in the etiology of pre-eclampsia.

Original languageEnglish
Pages (from-to)11-20
Number of pages10
JournalAmerican Journal of Reproductive Immunology
Volume58
Issue number1
DOIs
Publication statusPublished - 01-07-2007

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Indoleamine-Pyrrole 2,3,-Dioxygenase
Pre-Eclampsia
Placenta
Pregnancy
Enzymes
Fetus
Mothers
Blood Pressure
T-Lymphocytes
Messenger RNA

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Reproductive Medicine
  • Obstetrics and Gynaecology

Cite this

Nishizawa, Haruki ; Hasegawa, Kiyoshi ; Suzuki, Machiko ; Kamoshida, Shingo ; Kato, Takema ; Saito, Kuniaki ; Tsutsumi, Yutaka ; Kurahashi, Hiroki ; Udagawa, Yasuhiro. / The etiological role of allogeneic fetal rejection in pre-eclampsia. In: American Journal of Reproductive Immunology. 2007 ; Vol. 58, No. 1. pp. 11-20.
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The etiological role of allogeneic fetal rejection in pre-eclampsia. / Nishizawa, Haruki; Hasegawa, Kiyoshi; Suzuki, Machiko; Kamoshida, Shingo; Kato, Takema; Saito, Kuniaki; Tsutsumi, Yutaka; Kurahashi, Hiroki; Udagawa, Yasuhiro.

In: American Journal of Reproductive Immunology, Vol. 58, No. 1, 01.07.2007, p. 11-20.

Research output: Contribution to journalArticle

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AU - Nishizawa, Haruki

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AU - Saito, Kuniaki

AU - Tsutsumi, Yutaka

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