TY - JOUR
T1 - The etiological role of allogeneic fetal rejection in pre-eclampsia
AU - Nishizawa, Haruki
AU - Hasegawa, Kiyoshi
AU - Suzuki, Machiko
AU - Kamoshida, Shingo
AU - Kato, Takema
AU - Saito, Kuniaki
AU - Tsutsumi, Yutaka
AU - Kurahashi, Hiroki
AU - Udagawa, Yasuhiro
PY - 2007/7
Y1 - 2007/7
N2 - Problem: It has been demonstrated that allogeneic fetal rejection in normal pregnancy is prevented by placental indoleamine 2,3-dioxygenase (IDO). Further, an immunological etiology has been implicated in pre-eclampsia. Method of study: We examined the differences in placental IDO activity between normal and pre-eclamptic pregnancies. Results: IDO mRNA expression and enzyme activity levels in the placenta were low in patients with severe pre-eclampsia. The enzyme activity also inversely correlates with the blood pressure of the patients. In the placentas from severe pre-eclampsia, IDO immunoreactivity was low, whereas regional T-cell infiltration was observed reciprocally proportional to the IDO activity. Conclusion: Our findings implicate a potential role for IDO activity and a maternal immunological reaction against an allogeneic fetus in the etiology of pre-eclampsia.
AB - Problem: It has been demonstrated that allogeneic fetal rejection in normal pregnancy is prevented by placental indoleamine 2,3-dioxygenase (IDO). Further, an immunological etiology has been implicated in pre-eclampsia. Method of study: We examined the differences in placental IDO activity between normal and pre-eclamptic pregnancies. Results: IDO mRNA expression and enzyme activity levels in the placenta were low in patients with severe pre-eclampsia. The enzyme activity also inversely correlates with the blood pressure of the patients. In the placentas from severe pre-eclampsia, IDO immunoreactivity was low, whereas regional T-cell infiltration was observed reciprocally proportional to the IDO activity. Conclusion: Our findings implicate a potential role for IDO activity and a maternal immunological reaction against an allogeneic fetus in the etiology of pre-eclampsia.
UR - https://www.scopus.com/pages/publications/34250651274
UR - https://www.scopus.com/inward/citedby.url?scp=34250651274&partnerID=8YFLogxK
U2 - 10.1111/j.1600-0897.2007.00484.x
DO - 10.1111/j.1600-0897.2007.00484.x
M3 - Article
C2 - 17565543
AN - SCOPUS:34250651274
SN - 1046-7408
VL - 58
SP - 11
EP - 20
JO - American Journal of Reproductive Immunology
JF - American Journal of Reproductive Immunology
IS - 1
ER -