The extracellular domain of teneurin-4 promotes cell adhesion for oligodendrocyte differentiation

Chikako Hayashi, Nobuharu Suzuki, Yo Mabuchi, Naomi Kikura, Yukina Hosoda, Susana de Vega, Chihiro Akazawa

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Cell adhesion between oligodendrocytes and neuronal axons is a critical step for myelination that enables the rapid propagation of action potential in the central nervous system. Here, we show that the transmembrane protein teneurin-4 plays a role in the cell adhesion required for the differentiation of oligodendrocytes. We found that teneurin-4 formed molecular complexes with all of the four teneurin family members and promoted cell-cell adhesion. Oligodendrocyte lineage cells attached to the recombinant extracellular domain of all the teneurins and formed well-branched cell processes. In an axon-mimicking nanofibers assay, nanofibers coated with the recombinant teneurin-4 extracellular domain increased the differentiation of oligodendrocytes. Our results show that teneurin-4 binds to all teneurins through their extracellular domain, which facilitates the oligodendrocyte-axon adhesion, and promotes oligodendrocyte differentiation via its homophilic interaction.

Original languageEnglish
Pages (from-to)171-176
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume523
Issue number1
DOIs
Publication statusPublished - 26-02-2020
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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