Abstract
Changes in contractile properties of soleus and extensor digitorum longus in response to hindlimb suspension and/or altered high-energy phosphate contents were studied in rats. High-energy phosphates, especially phosphocreatine, in hindlimb muscles were lowered by feeding creatine analogue β-guanidinopropionic acid (β-GPA), but they were recovered after 10-d supplementation of creatine. The one-half relaxation time was increased by feeding β-GPA. Fatigue resistance was also improved in muscle treated with β-GPA. Such a shift was reversed by feeding creatine or by hindlimb suspension : However, the suspension induced shift of contracile properties toward fast-type was not prevented completely by β-GPA feeding. It is suggested that the levels of high-energy phosphates and tension production play important roles in the regulation of contractile properties.
| Original language | English |
|---|---|
| Pages (from-to) | 200-202 |
| Number of pages | 3 |
| Journal | Japanese Journal of Aerospace and Environmental Medicine |
| Volume | 33 |
| Issue number | 3 |
| Publication status | Published - 1996 |
| Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Public Health, Environmental and Occupational Health
