The Frizzled 3 gene is associated with methamphetamine psychosis in the Japanese population

Makiko Kishimoto, Hiroshi Ujike, Yuko Okahisa, Tatsuya Kotaka, Manabu Takaki, Masafumi Kodama, Toshiya Inada, Mitsuhiko Yamada, Naohisa Uchimura, Nakao Iwata, Ichiro Sora, Masaomi Iyo, Norio Ozaki, Shigetoshi Kuroda

Research output: Contribution to journalArticle

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Abstract

Background: Frizzled 3 (Fzd3) is a receptor required for the Wnt-signaling pathway, which has been implicated in the development of the central nervous system, including synaptogenesis and structural plasticity. We previously found a significant association between the FZD3 gene and susceptibility to schizophrenia, but subsequent studies showed inconsistent findings. To understand the roles of the FZD3 gene in psychotic disorders further, it should be useful to examine FZD3 in patients with methamphetamine psychosis because the clinical features of methamphetamine psychosis are similar to those of schizophrenia. Methods: Six SNPs of FZD3, rs3757888 in the 3′ flanking region, rs960914 in the intron 3, rs2241802, a synonymous SNP in the exon5, rs232301 and rs352203 in the intron 5, and rs880481 in the intron 7, were selected based on the previous schizophrenic studies and analyzed in 188 patients with methamphetamine psychosis and 240 age- and gender-matched controls. Results: A case-control association analyses revealed that two kinds of FZD3 haplotypes showed strong associations with methamphetamine psychosis (p < 0.00001). Having the G-A-T-G or A-G-C-A haplotype of rs2241802-rs2323019-rs352203-rs880481 was a potent negative risk factor (odds ratios were 0.13 and 0.086, respectively) for methamphetamine psychosis. Conclusion: Our present and previous findings indicate that genetic variants of the FZD3 gene affect susceptibility to two analogous but distinct dopamine-related psychoses, endogenous and substance-induced psychosis.

Original languageEnglish
Article number37
JournalBehavioral and Brain Functions
Volume4
DOIs
Publication statusPublished - 15-08-2008

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Methamphetamine
Psychotic Disorders
Population
Genes
Introns
Haplotypes
Single Nucleotide Polymorphism
Schizophrenia
Substance-Induced Psychoses
3' Flanking Region
Wnt Signaling Pathway
Dopamine
Central Nervous System
Odds Ratio

All Science Journal Classification (ASJC) codes

  • Cognitive Neuroscience
  • Biological Psychiatry
  • Behavioral Neuroscience

Cite this

Kishimoto, M., Ujike, H., Okahisa, Y., Kotaka, T., Takaki, M., Kodama, M., ... Kuroda, S. (2008). The Frizzled 3 gene is associated with methamphetamine psychosis in the Japanese population. Behavioral and Brain Functions, 4, [37]. https://doi.org/10.1186/1744-9081-4-37
Kishimoto, Makiko ; Ujike, Hiroshi ; Okahisa, Yuko ; Kotaka, Tatsuya ; Takaki, Manabu ; Kodama, Masafumi ; Inada, Toshiya ; Yamada, Mitsuhiko ; Uchimura, Naohisa ; Iwata, Nakao ; Sora, Ichiro ; Iyo, Masaomi ; Ozaki, Norio ; Kuroda, Shigetoshi. / The Frizzled 3 gene is associated with methamphetamine psychosis in the Japanese population. In: Behavioral and Brain Functions. 2008 ; Vol. 4.
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abstract = "Background: Frizzled 3 (Fzd3) is a receptor required for the Wnt-signaling pathway, which has been implicated in the development of the central nervous system, including synaptogenesis and structural plasticity. We previously found a significant association between the FZD3 gene and susceptibility to schizophrenia, but subsequent studies showed inconsistent findings. To understand the roles of the FZD3 gene in psychotic disorders further, it should be useful to examine FZD3 in patients with methamphetamine psychosis because the clinical features of methamphetamine psychosis are similar to those of schizophrenia. Methods: Six SNPs of FZD3, rs3757888 in the 3′ flanking region, rs960914 in the intron 3, rs2241802, a synonymous SNP in the exon5, rs232301 and rs352203 in the intron 5, and rs880481 in the intron 7, were selected based on the previous schizophrenic studies and analyzed in 188 patients with methamphetamine psychosis and 240 age- and gender-matched controls. Results: A case-control association analyses revealed that two kinds of FZD3 haplotypes showed strong associations with methamphetamine psychosis (p < 0.00001). Having the G-A-T-G or A-G-C-A haplotype of rs2241802-rs2323019-rs352203-rs880481 was a potent negative risk factor (odds ratios were 0.13 and 0.086, respectively) for methamphetamine psychosis. Conclusion: Our present and previous findings indicate that genetic variants of the FZD3 gene affect susceptibility to two analogous but distinct dopamine-related psychoses, endogenous and substance-induced psychosis.",
author = "Makiko Kishimoto and Hiroshi Ujike and Yuko Okahisa and Tatsuya Kotaka and Manabu Takaki and Masafumi Kodama and Toshiya Inada and Mitsuhiko Yamada and Naohisa Uchimura and Nakao Iwata and Ichiro Sora and Masaomi Iyo and Norio Ozaki and Shigetoshi Kuroda",
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Kishimoto, M, Ujike, H, Okahisa, Y, Kotaka, T, Takaki, M, Kodama, M, Inada, T, Yamada, M, Uchimura, N, Iwata, N, Sora, I, Iyo, M, Ozaki, N & Kuroda, S 2008, 'The Frizzled 3 gene is associated with methamphetamine psychosis in the Japanese population', Behavioral and Brain Functions, vol. 4, 37. https://doi.org/10.1186/1744-9081-4-37

The Frizzled 3 gene is associated with methamphetamine psychosis in the Japanese population. / Kishimoto, Makiko; Ujike, Hiroshi; Okahisa, Yuko; Kotaka, Tatsuya; Takaki, Manabu; Kodama, Masafumi; Inada, Toshiya; Yamada, Mitsuhiko; Uchimura, Naohisa; Iwata, Nakao; Sora, Ichiro; Iyo, Masaomi; Ozaki, Norio; Kuroda, Shigetoshi.

In: Behavioral and Brain Functions, Vol. 4, 37, 15.08.2008.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The Frizzled 3 gene is associated with methamphetamine psychosis in the Japanese population

AU - Kishimoto, Makiko

AU - Ujike, Hiroshi

AU - Okahisa, Yuko

AU - Kotaka, Tatsuya

AU - Takaki, Manabu

AU - Kodama, Masafumi

AU - Inada, Toshiya

AU - Yamada, Mitsuhiko

AU - Uchimura, Naohisa

AU - Iwata, Nakao

AU - Sora, Ichiro

AU - Iyo, Masaomi

AU - Ozaki, Norio

AU - Kuroda, Shigetoshi

PY - 2008/8/15

Y1 - 2008/8/15

N2 - Background: Frizzled 3 (Fzd3) is a receptor required for the Wnt-signaling pathway, which has been implicated in the development of the central nervous system, including synaptogenesis and structural plasticity. We previously found a significant association between the FZD3 gene and susceptibility to schizophrenia, but subsequent studies showed inconsistent findings. To understand the roles of the FZD3 gene in psychotic disorders further, it should be useful to examine FZD3 in patients with methamphetamine psychosis because the clinical features of methamphetamine psychosis are similar to those of schizophrenia. Methods: Six SNPs of FZD3, rs3757888 in the 3′ flanking region, rs960914 in the intron 3, rs2241802, a synonymous SNP in the exon5, rs232301 and rs352203 in the intron 5, and rs880481 in the intron 7, were selected based on the previous schizophrenic studies and analyzed in 188 patients with methamphetamine psychosis and 240 age- and gender-matched controls. Results: A case-control association analyses revealed that two kinds of FZD3 haplotypes showed strong associations with methamphetamine psychosis (p < 0.00001). Having the G-A-T-G or A-G-C-A haplotype of rs2241802-rs2323019-rs352203-rs880481 was a potent negative risk factor (odds ratios were 0.13 and 0.086, respectively) for methamphetamine psychosis. Conclusion: Our present and previous findings indicate that genetic variants of the FZD3 gene affect susceptibility to two analogous but distinct dopamine-related psychoses, endogenous and substance-induced psychosis.

AB - Background: Frizzled 3 (Fzd3) is a receptor required for the Wnt-signaling pathway, which has been implicated in the development of the central nervous system, including synaptogenesis and structural plasticity. We previously found a significant association between the FZD3 gene and susceptibility to schizophrenia, but subsequent studies showed inconsistent findings. To understand the roles of the FZD3 gene in psychotic disorders further, it should be useful to examine FZD3 in patients with methamphetamine psychosis because the clinical features of methamphetamine psychosis are similar to those of schizophrenia. Methods: Six SNPs of FZD3, rs3757888 in the 3′ flanking region, rs960914 in the intron 3, rs2241802, a synonymous SNP in the exon5, rs232301 and rs352203 in the intron 5, and rs880481 in the intron 7, were selected based on the previous schizophrenic studies and analyzed in 188 patients with methamphetamine psychosis and 240 age- and gender-matched controls. Results: A case-control association analyses revealed that two kinds of FZD3 haplotypes showed strong associations with methamphetamine psychosis (p < 0.00001). Having the G-A-T-G or A-G-C-A haplotype of rs2241802-rs2323019-rs352203-rs880481 was a potent negative risk factor (odds ratios were 0.13 and 0.086, respectively) for methamphetamine psychosis. Conclusion: Our present and previous findings indicate that genetic variants of the FZD3 gene affect susceptibility to two analogous but distinct dopamine-related psychoses, endogenous and substance-induced psychosis.

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U2 - 10.1186/1744-9081-4-37

DO - 10.1186/1744-9081-4-37

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