The granulocyte colony-stimulating factor produced in the human lung and its effect on liquid movement in the rabbit lung

Tsutomu Sakuma, Tasuku Nakada, Toshihiko Nishimura, Yasushi Hoshikawa, Shigefumi Fujimura

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Levels of the granulocyte colony-stimulating factor (G-CSF) were determined in the plasma and resected lung tissue from patients who underwent pulmonary resection. Moreover, the effect of recombinant human (rh) G-CSF on the permeability of pulmonary endothelium and on liquid clearance from the alveolar spaces was investigated in rabbits. The plasma levels of G-CSF increased from 30 pg/ml preoperatively to 409 ± 236 pg/ml 3 h postoperatively (P < 0.05), while the levels of G-CSF in the resected lung tissue were increased in the alveolar fluid, to 1,834 ± 1,054 pg/ml, and in the pulmonary blood, to 5,466 ± 2,019 pg/ml. It was found that rh G-CSF 25 μg administered into the subcutaneous tissue of rabbits increased extravascular lung water to 3.45 ± 0.26 vs 2.98 ± 0.20 in control experiments (P < 0.05); however, rhG-CSF 0.75 pg/kg administered into the alveloar spaces did not affect liquid clearance from the alveolar spaces. The findings of this study led us to conclude that G-CSF is synthesized in the human lung and increases the permeability of pulmonary endothelium, but not liquid clearance across the alveolar epithelium.

Original languageEnglish
Pages (from-to)1050-1055
Number of pages6
JournalSurgery Today
Volume24
Issue number12
DOIs
Publication statusPublished - 01-12-1994

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Granulocyte Colony-Stimulating Factor
Rabbits
Lung
Endothelium
Permeability
Extravascular Lung Water
Subcutaneous Tissue
Epithelium

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Sakuma, Tsutomu ; Nakada, Tasuku ; Nishimura, Toshihiko ; Hoshikawa, Yasushi ; Fujimura, Shigefumi. / The granulocyte colony-stimulating factor produced in the human lung and its effect on liquid movement in the rabbit lung. In: Surgery Today. 1994 ; Vol. 24, No. 12. pp. 1050-1055.
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The granulocyte colony-stimulating factor produced in the human lung and its effect on liquid movement in the rabbit lung. / Sakuma, Tsutomu; Nakada, Tasuku; Nishimura, Toshihiko; Hoshikawa, Yasushi; Fujimura, Shigefumi.

In: Surgery Today, Vol. 24, No. 12, 01.12.1994, p. 1050-1055.

Research output: Contribution to journalArticle

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