The hemodynamics of cerebral aneurysms-recent developments and future prospects in the patient-specific modeling and blood simulation

Hemodynamics plays an important role in the initiation, growth, and rupture of cerebral aneurysms. Due to limitations in the spatial and temporal resolutions of medical image data, it is difficult to obtain detailed hemodynamic information such as the velocity field or the wall shear stress. If an aneurysm is located in a bifurcation segment, the hemodynamics are affected by flow distributions and the compliance of the arterial wall. Thus, the effects of the entire circulatory system become essential, as well as the vascular dynamics. This paper presents the fundamentals of hemodynamics and the recent developments in patient-specific modeling and simulation for cerebral aneurysms. Particularly, this paper focuses on the multi-scale simulation of the interaction between the blood flow and arterial wall in order to consider the effects of the entire circulatory system and the wall dynamics.