The hemolysis test of the Gyro C1E3 pump in pulsatile mode

Eiki Tayama, Tadashi Nakazawa, Yoshiyuki Takami, Kenzo Makinouchi, Satoshi Ohtsubo, Yukio Ohashi, Aron J.P. Andrade, Julie Glueck, Juergen Mueller, Yukihiko Nosé

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

While a centrifugal pump is generally used for nonpulsatile blood flow, it can also produce a pulsatile flow by alternating the impeller rotational speed (rpm) periodically. However, there is concern that this centrifugal pump pulsatile mode may induce added hemolysis as a result of the repeated acceleration and deceleration of rpm. Thus, a hemolysis study of the pulsatile modes of the Gym C1E3 centrifugal pump (Gyro-P) was conducted. The results were then compared with the nonpulsatile mode of the same Gyro pump (Gyro-N) and the nonpulsatile BioMedicus BP-80 (Bio-N) pump. Three different conditions were simulated: left ventricular assist device (LVAD), cardiopulmonary bypass (CPB), and percutaneous cardiopulmonary support (PCPS). The beating rate of the Gyro-P was set at 40 bpm, with repetition of 2 different impeller speeds (the lower rpm being 70% of the higher speed). The 2 impeller speeds were set to obtain the same average flow as that of the nonpulsatile mode. The hemolysis results of the Gyro-P were comparable to or better than those of the Bio-N, and no excessive hemolysis was observed, compared to the Gyro-N. In conclusion, the Gyro-P had an excellent hemolytic characteristic and generated no excessive hemolysis in most clinical usage conditions. With the concern of hemolysis eliminated, this pulsatile mode may have various possible advantages.

Original languageEnglish
Pages (from-to)675-679
Number of pages5
JournalArtificial Organs
Volume21
Issue number7
DOIs
Publication statusPublished - 01-01-1997
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering

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