The human homolog of Sex comb on midleg (SCMH1) maps to chromosome 1p34

Joel Berger, Hiroki Kurahashi, Yoshihiro Takihara, Kazunori Shimada, Hugh W. Brock, Filippo Randazzo

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Polycomb group genes were originally identified in Drosophila as repressors required to maintain the silenced state of homeotic loci. About ten Polycomb group genes have been cloned in Drosophila, and mammalian homologs have been identified for most of these. Here, we isolate cDNAs encoding two isoforms of a human homolog of Drosophila Sex comb on midleg (Scm), named Sex comb on midleg homolog-1 (SCMH1). Overall, SCMH1 has 94% identity to its mouse counterpart Scmh1, and 41% identity to Scm, and contains two l (3)mbt domains, and the SPM domain that are characteristic of Scm. SCMH1 is widely expressed in adult tissues, and maps to chromosome 1p34. (C) 1999 Elsevier Science B.V. All rights reserved.

Original languageEnglish
Pages (from-to)185-191
Number of pages7
JournalGene
Volume237
Issue number1
DOIs
Publication statusPublished - 03-09-1999
Externally publishedYes

Fingerprint

Comb and Wattles
Chromosomes
Drosophila
Sex Characteristics
Genes
Protein Isoforms
Complementary DNA

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

Berger, J., Kurahashi, H., Takihara, Y., Shimada, K., Brock, H. W., & Randazzo, F. (1999). The human homolog of Sex comb on midleg (SCMH1) maps to chromosome 1p34. Gene, 237(1), 185-191. https://doi.org/10.1016/S0378-1119(99)00285-1
Berger, Joel ; Kurahashi, Hiroki ; Takihara, Yoshihiro ; Shimada, Kazunori ; Brock, Hugh W. ; Randazzo, Filippo. / The human homolog of Sex comb on midleg (SCMH1) maps to chromosome 1p34. In: Gene. 1999 ; Vol. 237, No. 1. pp. 185-191.
@article{d4acdf95d1024cb6ae6aff69f1c97723,
title = "The human homolog of Sex comb on midleg (SCMH1) maps to chromosome 1p34",
abstract = "Polycomb group genes were originally identified in Drosophila as repressors required to maintain the silenced state of homeotic loci. About ten Polycomb group genes have been cloned in Drosophila, and mammalian homologs have been identified for most of these. Here, we isolate cDNAs encoding two isoforms of a human homolog of Drosophila Sex comb on midleg (Scm), named Sex comb on midleg homolog-1 (SCMH1). Overall, SCMH1 has 94{\%} identity to its mouse counterpart Scmh1, and 41{\%} identity to Scm, and contains two l (3)mbt domains, and the SPM domain that are characteristic of Scm. SCMH1 is widely expressed in adult tissues, and maps to chromosome 1p34. (C) 1999 Elsevier Science B.V. All rights reserved.",
author = "Joel Berger and Hiroki Kurahashi and Yoshihiro Takihara and Kazunori Shimada and Brock, {Hugh W.} and Filippo Randazzo",
year = "1999",
month = "9",
day = "3",
doi = "10.1016/S0378-1119(99)00285-1",
language = "English",
volume = "237",
pages = "185--191",
journal = "Gene",
issn = "0378-1119",
publisher = "Elsevier",
number = "1",

}

Berger, J, Kurahashi, H, Takihara, Y, Shimada, K, Brock, HW & Randazzo, F 1999, 'The human homolog of Sex comb on midleg (SCMH1) maps to chromosome 1p34', Gene, vol. 237, no. 1, pp. 185-191. https://doi.org/10.1016/S0378-1119(99)00285-1

The human homolog of Sex comb on midleg (SCMH1) maps to chromosome 1p34. / Berger, Joel; Kurahashi, Hiroki; Takihara, Yoshihiro; Shimada, Kazunori; Brock, Hugh W.; Randazzo, Filippo.

In: Gene, Vol. 237, No. 1, 03.09.1999, p. 185-191.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The human homolog of Sex comb on midleg (SCMH1) maps to chromosome 1p34

AU - Berger, Joel

AU - Kurahashi, Hiroki

AU - Takihara, Yoshihiro

AU - Shimada, Kazunori

AU - Brock, Hugh W.

AU - Randazzo, Filippo

PY - 1999/9/3

Y1 - 1999/9/3

N2 - Polycomb group genes were originally identified in Drosophila as repressors required to maintain the silenced state of homeotic loci. About ten Polycomb group genes have been cloned in Drosophila, and mammalian homologs have been identified for most of these. Here, we isolate cDNAs encoding two isoforms of a human homolog of Drosophila Sex comb on midleg (Scm), named Sex comb on midleg homolog-1 (SCMH1). Overall, SCMH1 has 94% identity to its mouse counterpart Scmh1, and 41% identity to Scm, and contains two l (3)mbt domains, and the SPM domain that are characteristic of Scm. SCMH1 is widely expressed in adult tissues, and maps to chromosome 1p34. (C) 1999 Elsevier Science B.V. All rights reserved.

AB - Polycomb group genes were originally identified in Drosophila as repressors required to maintain the silenced state of homeotic loci. About ten Polycomb group genes have been cloned in Drosophila, and mammalian homologs have been identified for most of these. Here, we isolate cDNAs encoding two isoforms of a human homolog of Drosophila Sex comb on midleg (Scm), named Sex comb on midleg homolog-1 (SCMH1). Overall, SCMH1 has 94% identity to its mouse counterpart Scmh1, and 41% identity to Scm, and contains two l (3)mbt domains, and the SPM domain that are characteristic of Scm. SCMH1 is widely expressed in adult tissues, and maps to chromosome 1p34. (C) 1999 Elsevier Science B.V. All rights reserved.

UR - http://www.scopus.com/inward/record.url?scp=0032839232&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032839232&partnerID=8YFLogxK

U2 - 10.1016/S0378-1119(99)00285-1

DO - 10.1016/S0378-1119(99)00285-1

M3 - Article

C2 - 10524249

AN - SCOPUS:0032839232

VL - 237

SP - 185

EP - 191

JO - Gene

JF - Gene

SN - 0378-1119

IS - 1

ER -