The human homolog of Sex comb on midleg (SCMH1) maps to chromosome 1p34

Joel Berger, Hiroki Kurahashi, Yoshihiro Takihara, Kazunori Shimada, Hugh W. Brock, Filippo Randazzo

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)


Polycomb group genes were originally identified in Drosophila as repressors required to maintain the silenced state of homeotic loci. About ten Polycomb group genes have been cloned in Drosophila, and mammalian homologs have been identified for most of these. Here, we isolate cDNAs encoding two isoforms of a human homolog of Drosophila Sex comb on midleg (Scm), named Sex comb on midleg homolog-1 (SCMH1). Overall, SCMH1 has 94% identity to its mouse counterpart Scmh1, and 41% identity to Scm, and contains two l (3)mbt domains, and the SPM domain that are characteristic of Scm. SCMH1 is widely expressed in adult tissues, and maps to chromosome 1p34. (C) 1999 Elsevier Science B.V. All rights reserved.

Original languageEnglish
Pages (from-to)185-191
Number of pages7
Issue number1
Publication statusPublished - 03-09-1999
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Genetics


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