TY - JOUR
T1 - The impact of body mass index on oncological outcomes in colorectal cancer patients with curative intent
AU - Toiyama, Yuji
AU - Hiro, Junichiro
AU - Shimura, Tadanobu
AU - Fujikawa, Hiroyuki
AU - Ohi, Masaki
AU - Tanaka, Koji
AU - Inoue, Yasuhiro
AU - Mohri, Yasuhiko
AU - Kusunoki, Masato
N1 - Publisher Copyright:
© 2016, Japan Society of Clinical Oncology.
PY - 2016/12/1
Y1 - 2016/12/1
N2 - Background: Excess body weight is associated with a risk of several malignancies, including colon cancer. However, the oncological significance of evaluating body mass index (BMI) preoperatively in colorectal cancer (CRC) patients undergoing curative surgery has not been fully evaluated. Methods: Clinicopathological findings including BMI and laboratory data [carcinoembryonic antigen (CEA) and neutrophil/lymphocyte ratio (NLR)] from 358 curative CRC patients (open surgery group: n = 157; laparoscopic surgery group: n = 201) were assessed as indicators of survival outcome. BMI <20 was defined as underweight in both groups. Results: Not all categories of pathological findings were associated with BMI in both groups. Patients with BMI <20 showed significant poorer overall survival (OS) in the open surgery group. In addition, patients with BMI <20 in the laparoscopic surgery group were also significantly worse in OS and disease-free survival (DFS). Furthermore, multivariate analysis demonstrated that BMI was validated as independent predictors for OS and DFS in both groups. BMI had a significant negative correlation with NLR, which reflects host immune response in both groups. Conclusions: Lower BMI is a promising predictor of recurrence and prognosis in curative CRC patients.
AB - Background: Excess body weight is associated with a risk of several malignancies, including colon cancer. However, the oncological significance of evaluating body mass index (BMI) preoperatively in colorectal cancer (CRC) patients undergoing curative surgery has not been fully evaluated. Methods: Clinicopathological findings including BMI and laboratory data [carcinoembryonic antigen (CEA) and neutrophil/lymphocyte ratio (NLR)] from 358 curative CRC patients (open surgery group: n = 157; laparoscopic surgery group: n = 201) were assessed as indicators of survival outcome. BMI <20 was defined as underweight in both groups. Results: Not all categories of pathological findings were associated with BMI in both groups. Patients with BMI <20 showed significant poorer overall survival (OS) in the open surgery group. In addition, patients with BMI <20 in the laparoscopic surgery group were also significantly worse in OS and disease-free survival (DFS). Furthermore, multivariate analysis demonstrated that BMI was validated as independent predictors for OS and DFS in both groups. BMI had a significant negative correlation with NLR, which reflects host immune response in both groups. Conclusions: Lower BMI is a promising predictor of recurrence and prognosis in curative CRC patients.
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U2 - 10.1007/s10147-016-1016-7
DO - 10.1007/s10147-016-1016-7
M3 - Article
C2 - 27402104
AN - SCOPUS:84978036030
SN - 1341-9625
VL - 21
SP - 1102
EP - 1110
JO - International Journal of Clinical Oncology
JF - International Journal of Clinical Oncology
IS - 6
ER -