The impact of musculoskeletal diseases on mortality–comparison with internal diseases: A 15-year longitudinal study

Takehiro Kasai, Yukiharu Hasegawa, Shiro Imagama, Tadahiro Sakai, Kenji Wakai, Koji Suzuki, Naoki Ishiguro

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


Background Aging is associated with an increased incidence of diabetes (DM), hypertension (HT), hyperlipidemia (HL), as well as musculoskeletal disorders, such as osteoarthritis (OA) and osteoporosis (OP). However, the impact of musculoskeletal disorders on mortality remains unclear. This study investigated the risk of mortality if having knee OA or OP. Methods 601 participants (mean age 67.8 ± 5.3 years) who underwent musculoskeletal check-ups in Yakumo town were enrolled in this study, 248 were males and 353 were females. The following parameters were assessed: age, sex, body mass index, smoking habit, alcohol drinking habit, physical exercise habit, knee OA, OP, HT, DM and HL. Kaplan–Meier survival curves for smoking, drinking and physical exercise habits, knee OA, OP, HT, DM and HL were prepared, and the log-rank test was performed. Furthermore, the Cox hazard model was used for multivariate analysis of all variables. Results Knee OA, OP, HT, and DM were associated with a significantly higher mortality rate. Cox regression analysis results showed a hazard ratio of 1.972 for OA (95%CI: 1.356–2.867), 1.965 for DM (1.146–3.368), 1.706 for smoking habits (1.141–2.552), and 1.614 for OP (1.126–2.313). Cardiovascular diseases were the most common causes of death. Conclusions Smoking, knee OA, OP and DM were all associated with increased risk of mortality. Knee OA had a high hazard ratio, comparable to that of DM. These findings suggest that interventions against smoking, knee OA, OP and DM may reduce the risk of mortality.

Original languageEnglish
Pages (from-to)1126-1131
Number of pages6
JournalJournal of Orthopaedic Science
Issue number6
Publication statusPublished - 11-2017

All Science Journal Classification (ASJC) codes

  • Surgery
  • Orthopedics and Sports Medicine


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