The impact of rejection episodes during acute tubular necrosis - Diagnosis and allograft outcome after cadaveric renal transplants

Kiyotaka Hoshinaga, Ryoichi Shiroki, Yusuke Kubota, Takahiro Maruyama, Touru Higuchi, Yasuhiko Tsukiashi, Masanobu Izumitani, Masaki Horiba, Yorio Naide

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Abstract

Diagnosis of acute rejection (AR) is difficult during acute tubular necrosis (ATN), and a delay of rejection treatment could result in negative impacts on the renal transplant outcome. At our center, 68 cadaveric kidneys were transplanted during the past 7 years. The 1-, 3- and 5-year graft survival rates were 95.4%, 93.8% and 81.4%, respectively. After the transplants, 16 patients had immediate graft function (G-I), 51 patients experienced ATN for 12.0±9.3 days, and one patient had a nonfunctioning graft due to diffuse arteriolar thrombosis caused by DIC in the donor. During ATN, 41 patients had no rejection episodes (G-II) and 10 patients had ARs (G-III). Nine patients were treated with bolus steroid and one with steroid and OKT-3. Although scintigraphic and sonographic examinations were routinely employed, only the histopathological findings of needle biopsies were helpful for the diagnosis of AR during ATN. When the transplant outcome was compared, the serum creatinene level was highest in G-III and lowest in G-I (1.48 vs 1.06 mg/dl, p<0.05). The posttransplant ATN period was also longer in G-III compared to G-II (23.9 vs 9.1 days, p<0.005). The 5-yaar graft survival rate was 85.2% in G-I, 88.0% in G-II and 59.3% in G-III. We conclude that routine serial renal biopsies should be scheduled when ATN develops after the cadaveric renal transplant, since only the histopathological diagnosis is reliable during ATN.

Original languageEnglish
Pages (from-to)341-346
Number of pages6
JournalActa Urologica Japonica
Volume44
Issue number5
Publication statusPublished - 01-05-1998

All Science Journal Classification (ASJC) codes

  • Urology

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