The importance of CD25(sup)+(/sup)CD4(sup)+(/sup) regulatory T cells in mouse hepatic allograft tolerance

Xiaofeng Jiang, Miwa Morita, Atsushi Sugioka, Michishige Harada, Satoshi Kojo, Hiroshi Wakao, Hiroshi Watarai, Nobuhiro Ohkohchi, Masaru Taniguchi, Ken Ichiro Seino

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Abstract

In mouse liver transplantation, tolerance is readily inducible. Recent studies have revealed that CD25+CD4+ regulatory T cells play an important role in regulating various immune responses, including transplant tolerance. However, the contribution of these cells to tolerance in mouse liver transplantation has not been elucidated. We showed here that depletion of CD25+CD4+ T cells increased proliferative response of CD4+ T cells and cytotoxic T lymphocyte induction of CD8+ T cells. Depletion of these cells in the recipient but not in the donor before liver transplantation caused rejection. Furthermore, the number of CD25+CD4+ population and forkhead/winged helix transcription factor expression in liver mononuclear lymphocytes derived from tolerant mice were higher than those from grafts undergoing rejection. In conclusion, these results indicate that CD25+CD4+ regulatory T cells in the recipient but not in the donor of liver transplantation are important for the tolerance induction.

Original languageEnglish
Pages (from-to)1112-1118
Number of pages7
JournalLiver Transplantation
Volume12
Issue number7
DOIs
Publication statusPublished - 01-07-2006

All Science Journal Classification (ASJC) codes

  • Surgery
  • Hepatology
  • Transplantation

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    Jiang, X., Morita, M., Sugioka, A., Harada, M., Kojo, S., Wakao, H., Watarai, H., Ohkohchi, N., Taniguchi, M., & Seino, K. I. (2006). The importance of CD25(sup)+(/sup)CD4(sup)+(/sup) regulatory T cells in mouse hepatic allograft tolerance. Liver Transplantation, 12(7), 1112-1118. https://doi.org/10.1002/lt.20787