The influence of polymorphisms of interleukin-17A and interleukin-17F genes on the susceptibility to ulcerative colitis

Tomiyasu Arisawa; Tomomitsu Tahara; Tomoyuki Shibata; Mitsuo Nagasaka; Masakatsu Nakamura; Yoshio Kamiya; Hiroshi Fujita; Masahiko Nakamura; Daisuke Yoshioka; Yuko Arima; Masaaki Okubo; Ichiro Hirata; Hiroshi Nakano

doi:10.1007/s10875-007-9125-8

The influence of polymorphisms of interleukin-17A and interleukin-17F genes on the susceptibility to ulcerative colitis

Tomiyasu Arisawa
, Tomomitsu Tahara
, Tomoyuki Shibata
, Mitsuo Nagasaka
, Masakatsu Nakamura
, Yoshio Kamiya
, Hiroshi Fujita
, Masahiko Nakamura
, Daisuke Yoshioka
, Yuko Arima
, Masaaki Okubo
, Ichiro Hirata
, Hiroshi Nakano

Internal Medicine

Research output: Contribution to journal › Article › peer-review

185 Citations (Scopus)

Abstract

We investigated the association between ulcerative colitis (UC) and polymorphisms of IL-17A (rs2275913, G-197A) and IL-17F (rs763780, 7488T/C) genes. We employed the multiplex PCR-SSCP method to detect gene polymorphisms. Both the numbers of -197A (IL-17A) and 7488T (IL-17F) alleles were significantly correlated to the development of UC. The frequencies of -197A/A and 7488T/T genotypes in the UC group were significantly higher than those in the non-UC group. An adjusted analysis revealed that -197A and 7488T alleles were independent risk factors for the developing UC. In addition, both polymorphisms were significantly associated with the pancolitis phenotype. Furthermore, -197A allele was significantly correlated to the chronic relapsing phenotype and -197A/A homozygote was more frequent in steroid-dependent cases, whereas 7488T allele was correlated with the chronic continuous phenotype. Our results provided the first evidence that -197A (IL-17A) and 7488T (IL-17F) alleles may influence the susceptibility to and pathophysiological features of UC independently.

Original language	English
Pages (from-to)	44-49
Number of pages	6
Journal	Journal of Clinical Immunology
Volume	28
Issue number	1
DOIs	https://doi.org/10.1007/s10875-007-9125-8
Publication status	Published - 01-2008

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology

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10.1007/s10875-007-9125-8

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Arisawa, T., Tahara, T., Shibata, T., Nagasaka, M., Nakamura, M., Kamiya, Y., Fujita, H., Nakamura, M., Yoshioka, D., Arima, Y., Okubo, M., Hirata, I., & Nakano, H. (2008). The influence of polymorphisms of interleukin-17A and interleukin-17F genes on the susceptibility to ulcerative colitis. Journal of Clinical Immunology, 28(1), 44-49. https://doi.org/10.1007/s10875-007-9125-8

@article{d19edce9152c4337a626b7ea1f417ad2,

title = "The influence of polymorphisms of interleukin-17A and interleukin-17F genes on the susceptibility to ulcerative colitis",

abstract = "We investigated the association between ulcerative colitis (UC) and polymorphisms of IL-17A (rs2275913, G-197A) and IL-17F (rs763780, 7488T/C) genes. We employed the multiplex PCR-SSCP method to detect gene polymorphisms. Both the numbers of -197A (IL-17A) and 7488T (IL-17F) alleles were significantly correlated to the development of UC. The frequencies of -197A/A and 7488T/T genotypes in the UC group were significantly higher than those in the non-UC group. An adjusted analysis revealed that -197A and 7488T alleles were independent risk factors for the developing UC. In addition, both polymorphisms were significantly associated with the pancolitis phenotype. Furthermore, -197A allele was significantly correlated to the chronic relapsing phenotype and -197A/A homozygote was more frequent in steroid-dependent cases, whereas 7488T allele was correlated with the chronic continuous phenotype. Our results provided the first evidence that -197A (IL-17A) and 7488T (IL-17F) alleles may influence the susceptibility to and pathophysiological features of UC independently.",

keywords = "Interleukin-17 (IL-17), Single nucleotide polymorphism (SNP), Ulcerative colitis",

author = "Tomiyasu Arisawa and Tomomitsu Tahara and Tomoyuki Shibata and Mitsuo Nagasaka and Masakatsu Nakamura and Yoshio Kamiya and Hiroshi Fujita and Masahiko Nakamura and Daisuke Yoshioka and Yuko Arima and Masaaki Okubo and Ichiro Hirata and Hiroshi Nakano",

year = "2008",

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doi = "10.1007/s10875-007-9125-8",

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Arisawa, T, Tahara, T, Shibata, T , Nagasaka, M , Nakamura, M, Kamiya, Y, Fujita, H, Nakamura, M, Yoshioka, D, Arima, Y, Okubo, M, Hirata, I & Nakano, H 2008, 'The influence of polymorphisms of interleukin-17A and interleukin-17F genes on the susceptibility to ulcerative colitis', Journal of Clinical Immunology, vol. 28, no. 1, pp. 44-49. https://doi.org/10.1007/s10875-007-9125-8

TY - JOUR

T1 - The influence of polymorphisms of interleukin-17A and interleukin-17F genes on the susceptibility to ulcerative colitis

AU - Arisawa, Tomiyasu

AU - Tahara, Tomomitsu

AU - Shibata, Tomoyuki

AU - Nagasaka, Mitsuo

AU - Nakamura, Masakatsu

AU - Kamiya, Yoshio

AU - Fujita, Hiroshi

AU - Nakamura, Masahiko

AU - Yoshioka, Daisuke

AU - Arima, Yuko

AU - Okubo, Masaaki

AU - Hirata, Ichiro

AU - Nakano, Hiroshi

PY - 2008/1

Y1 - 2008/1

N2 - We investigated the association between ulcerative colitis (UC) and polymorphisms of IL-17A (rs2275913, G-197A) and IL-17F (rs763780, 7488T/C) genes. We employed the multiplex PCR-SSCP method to detect gene polymorphisms. Both the numbers of -197A (IL-17A) and 7488T (IL-17F) alleles were significantly correlated to the development of UC. The frequencies of -197A/A and 7488T/T genotypes in the UC group were significantly higher than those in the non-UC group. An adjusted analysis revealed that -197A and 7488T alleles were independent risk factors for the developing UC. In addition, both polymorphisms were significantly associated with the pancolitis phenotype. Furthermore, -197A allele was significantly correlated to the chronic relapsing phenotype and -197A/A homozygote was more frequent in steroid-dependent cases, whereas 7488T allele was correlated with the chronic continuous phenotype. Our results provided the first evidence that -197A (IL-17A) and 7488T (IL-17F) alleles may influence the susceptibility to and pathophysiological features of UC independently.

AB - We investigated the association between ulcerative colitis (UC) and polymorphisms of IL-17A (rs2275913, G-197A) and IL-17F (rs763780, 7488T/C) genes. We employed the multiplex PCR-SSCP method to detect gene polymorphisms. Both the numbers of -197A (IL-17A) and 7488T (IL-17F) alleles were significantly correlated to the development of UC. The frequencies of -197A/A and 7488T/T genotypes in the UC group were significantly higher than those in the non-UC group. An adjusted analysis revealed that -197A and 7488T alleles were independent risk factors for the developing UC. In addition, both polymorphisms were significantly associated with the pancolitis phenotype. Furthermore, -197A allele was significantly correlated to the chronic relapsing phenotype and -197A/A homozygote was more frequent in steroid-dependent cases, whereas 7488T allele was correlated with the chronic continuous phenotype. Our results provided the first evidence that -197A (IL-17A) and 7488T (IL-17F) alleles may influence the susceptibility to and pathophysiological features of UC independently.

KW - Interleukin-17 (IL-17)

KW - Single nucleotide polymorphism (SNP)

KW - Ulcerative colitis

UR - https://www.scopus.com/pages/publications/38149114618

UR - https://www.scopus.com/pages/publications/38149114618#tab=citedBy

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DO - 10.1007/s10875-007-9125-8

M3 - Article

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AN - SCOPUS:38149114618

SN - 0271-9142

VL - 28

SP - 44

EP - 49

JO - Journal of Clinical Immunology

JF - Journal of Clinical Immunology

IS - 1

ER -

The influence of polymorphisms of interleukin-17A and interleukin-17F genes on the susceptibility to ulcerative colitis

Abstract

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