The inhibitory effects of salmon calcitonin on intrathecally-injected N- methyl-D-aspartate-induced aversive behavior in mice

Toshitaka Nabeshima, Y. Maeda, K. Yamada, T. Nakamura, T. Hasegawa

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The effects of salmon calcitonin (SCT) on intrathecally-injected N- methyl-D-aspartate (NMDA)-induced aversive behavior were investigated to clarify the involvement of the NMDA receptor/ionophore complex on the analgesic effects of SCT. Intracerebroventricular (i.c.v.) injection of SCT significantly inhibited acetic acid-induced writhing. Intrathecal (i.t.) injection of NMDA (0.25-1.0 nmol/mouse) dose-dependently induced aversive behavior such as scratching and tail biting. SCT at the doses of 0.01 and 0.1 IU/mouse (i.c.v.) significantly inhibited the NMDA-induced aversive behavior. This inhibitory effects of SCT on NMDA (i.t.)-induced aversive behavior were neither potentiated nor antagonized by i.c.v. injection of MK-801 and NMDA, respectively. Further, MK-801 (i.c.v.) and NMDA (i.c.v.) themselves did not affect the NMDA (i.t.)-induced aversive behavior. These results suggest that the NMDA receptor/ionophore complex in the brain is not directly involved in the antinociceptive effects of intracerebrally-injected SCT.

Original languageEnglish
Pages (from-to)175-184
Number of pages10
JournalResearch Communications in Chemical Pathology and Pharmacology
Volume82
Issue number2
Publication statusPublished - 01-01-1993
Externally publishedYes

Fingerprint

salmon calcitonin
N-Methylaspartate
Dizocilpine Maleate
Ionophores
N-Methyl-D-Aspartate Receptors
Spinal Injections
Injections
Acetic Acid
Analgesics
Tail

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Pharmacology

Cite this

@article{d9f2461d6d474fc293f746971efb915d,
title = "The inhibitory effects of salmon calcitonin on intrathecally-injected N- methyl-D-aspartate-induced aversive behavior in mice",
abstract = "The effects of salmon calcitonin (SCT) on intrathecally-injected N- methyl-D-aspartate (NMDA)-induced aversive behavior were investigated to clarify the involvement of the NMDA receptor/ionophore complex on the analgesic effects of SCT. Intracerebroventricular (i.c.v.) injection of SCT significantly inhibited acetic acid-induced writhing. Intrathecal (i.t.) injection of NMDA (0.25-1.0 nmol/mouse) dose-dependently induced aversive behavior such as scratching and tail biting. SCT at the doses of 0.01 and 0.1 IU/mouse (i.c.v.) significantly inhibited the NMDA-induced aversive behavior. This inhibitory effects of SCT on NMDA (i.t.)-induced aversive behavior were neither potentiated nor antagonized by i.c.v. injection of MK-801 and NMDA, respectively. Further, MK-801 (i.c.v.) and NMDA (i.c.v.) themselves did not affect the NMDA (i.t.)-induced aversive behavior. These results suggest that the NMDA receptor/ionophore complex in the brain is not directly involved in the antinociceptive effects of intracerebrally-injected SCT.",
author = "Toshitaka Nabeshima and Y. Maeda and K. Yamada and T. Nakamura and T. Hasegawa",
year = "1993",
month = "1",
day = "1",
language = "English",
volume = "82",
pages = "175--184",
journal = "Research Communications in Chemical Pathology and Pharmacology",
issn = "0034-5164",
publisher = "PJD Publications Ltd",
number = "2",

}

The inhibitory effects of salmon calcitonin on intrathecally-injected N- methyl-D-aspartate-induced aversive behavior in mice. / Nabeshima, Toshitaka; Maeda, Y.; Yamada, K.; Nakamura, T.; Hasegawa, T.

In: Research Communications in Chemical Pathology and Pharmacology, Vol. 82, No. 2, 01.01.1993, p. 175-184.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The inhibitory effects of salmon calcitonin on intrathecally-injected N- methyl-D-aspartate-induced aversive behavior in mice

AU - Nabeshima, Toshitaka

AU - Maeda, Y.

AU - Yamada, K.

AU - Nakamura, T.

AU - Hasegawa, T.

PY - 1993/1/1

Y1 - 1993/1/1

N2 - The effects of salmon calcitonin (SCT) on intrathecally-injected N- methyl-D-aspartate (NMDA)-induced aversive behavior were investigated to clarify the involvement of the NMDA receptor/ionophore complex on the analgesic effects of SCT. Intracerebroventricular (i.c.v.) injection of SCT significantly inhibited acetic acid-induced writhing. Intrathecal (i.t.) injection of NMDA (0.25-1.0 nmol/mouse) dose-dependently induced aversive behavior such as scratching and tail biting. SCT at the doses of 0.01 and 0.1 IU/mouse (i.c.v.) significantly inhibited the NMDA-induced aversive behavior. This inhibitory effects of SCT on NMDA (i.t.)-induced aversive behavior were neither potentiated nor antagonized by i.c.v. injection of MK-801 and NMDA, respectively. Further, MK-801 (i.c.v.) and NMDA (i.c.v.) themselves did not affect the NMDA (i.t.)-induced aversive behavior. These results suggest that the NMDA receptor/ionophore complex in the brain is not directly involved in the antinociceptive effects of intracerebrally-injected SCT.

AB - The effects of salmon calcitonin (SCT) on intrathecally-injected N- methyl-D-aspartate (NMDA)-induced aversive behavior were investigated to clarify the involvement of the NMDA receptor/ionophore complex on the analgesic effects of SCT. Intracerebroventricular (i.c.v.) injection of SCT significantly inhibited acetic acid-induced writhing. Intrathecal (i.t.) injection of NMDA (0.25-1.0 nmol/mouse) dose-dependently induced aversive behavior such as scratching and tail biting. SCT at the doses of 0.01 and 0.1 IU/mouse (i.c.v.) significantly inhibited the NMDA-induced aversive behavior. This inhibitory effects of SCT on NMDA (i.t.)-induced aversive behavior were neither potentiated nor antagonized by i.c.v. injection of MK-801 and NMDA, respectively. Further, MK-801 (i.c.v.) and NMDA (i.c.v.) themselves did not affect the NMDA (i.t.)-induced aversive behavior. These results suggest that the NMDA receptor/ionophore complex in the brain is not directly involved in the antinociceptive effects of intracerebrally-injected SCT.

UR - http://www.scopus.com/inward/record.url?scp=0027333176&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027333176&partnerID=8YFLogxK

M3 - Article

VL - 82

SP - 175

EP - 184

JO - Research Communications in Chemical Pathology and Pharmacology

JF - Research Communications in Chemical Pathology and Pharmacology

SN - 0034-5164

IS - 2

ER -