The inhibitory effects of salmon calcitonin on intrathecally-injected N- methyl-D-aspartate-induced aversive behavior in mice

Toshitaka Nabeshima, Y. Maeda, K. Yamada, T. Nakamura, T. Hasegawa

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Abstract

The effects of salmon calcitonin (SCT) on intrathecally-injected N- methyl-D-aspartate (NMDA)-induced aversive behavior were investigated to clarify the involvement of the NMDA receptor/ionophore complex on the analgesic effects of SCT. Intracerebroventricular (i.c.v.) injection of SCT significantly inhibited acetic acid-induced writhing. Intrathecal (i.t.) injection of NMDA (0.25-1.0 nmol/mouse) dose-dependently induced aversive behavior such as scratching and tail biting. SCT at the doses of 0.01 and 0.1 IU/mouse (i.c.v.) significantly inhibited the NMDA-induced aversive behavior. This inhibitory effects of SCT on NMDA (i.t.)-induced aversive behavior were neither potentiated nor antagonized by i.c.v. injection of MK-801 and NMDA, respectively. Further, MK-801 (i.c.v.) and NMDA (i.c.v.) themselves did not affect the NMDA (i.t.)-induced aversive behavior. These results suggest that the NMDA receptor/ionophore complex in the brain is not directly involved in the antinociceptive effects of intracerebrally-injected SCT.

Original languageEnglish
Pages (from-to)175-184
Number of pages10
JournalResearch Communications in Chemical Pathology and Pharmacology
Volume82
Issue number2
Publication statusPublished - 01-01-1993
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Toxicology
  • Pharmacology

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