Abstract
In normal rats, muscarinic acetylcholine receptors (mAChRs) have a facilitating role on both short-term and long-term memory tested by Y-maze task and multi-trial passive avoidance test, respectively, since scopolamine, a specific mAChRs antagonist, impairs both types of memory. A low dose of nicotine (0.3 mg/kg b.w., i.p.), a specific nicotinic acetylcholine receptors (nAChRs) agonist, administered once caused a significant facilitating effect on short-term memory. A higher dose of nicotine (3 mg/kg b.w., i.p.) administered 5 consecutively days had about the same facilitating effect on short- and long-term memory without affecting information acquisition. In rats, having mAChRs and nAChRs blocked by means of scopolamine and chlorisondamine respectively, a low dose of nicotine administered once caused a significant improvement of long-term memory deficits without affecting significantly short-term memory. A higher dose of nicotine administered 5 consecutive days in rats with a double blockade of cholinergic receptors had the same ameliorating effect on long-term memory deficits as low dose. Our data suggest that the antiamnesic effect of nicotine can result from an action at nicotinic receptors subtypes not blocked by chlorisondamine or at nonnicotinic receptors.
| Original language | English |
|---|---|
| Pages (from-to) | 21-30 |
| Number of pages | 10 |
| Journal | Romanian journal of physiology : physiological sciences / [Academia de Stiinte Medicale] |
| Volume | 41 |
| Issue number | 1-2 |
| Publication status | Published - 01-01-2004 |
| Externally published | Yes |
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The interaction between the cholinergic and dopaminergic system in learning and memory process in rats. / Hefco, V.; Yamada, K.; Hefco, Andreea; Hritcu, L.; Tiron, A.; Nabeshima, Toshitaka.
In: Romanian journal of physiology : physiological sciences / [Academia de Stiinte Medicale], Vol. 41, No. 1-2, 01.01.2004, p. 21-30.Research output: Contribution to journal › Article
TY - JOUR
T1 - The interaction between the cholinergic and dopaminergic system in learning and memory process in rats.
AU - Hefco, V.
AU - Yamada, K.
AU - Hefco, Andreea
AU - Hritcu, L.
AU - Tiron, A.
AU - Nabeshima, Toshitaka
PY - 2004/1/1
Y1 - 2004/1/1
N2 - In normal rats, muscarinic acetylcholine receptors (mAChRs) have a facilitating role on both short-term and long-term memory tested by Y-maze task and multi-trial passive avoidance test, respectively, since scopolamine, a specific mAChRs antagonist, impairs both types of memory. A low dose of nicotine (0.3 mg/kg b.w., i.p.), a specific nicotinic acetylcholine receptors (nAChRs) agonist, administered once caused a significant facilitating effect on short-term memory. A higher dose of nicotine (3 mg/kg b.w., i.p.) administered 5 consecutively days had about the same facilitating effect on short- and long-term memory without affecting information acquisition. In rats, having mAChRs and nAChRs blocked by means of scopolamine and chlorisondamine respectively, a low dose of nicotine administered once caused a significant improvement of long-term memory deficits without affecting significantly short-term memory. A higher dose of nicotine administered 5 consecutive days in rats with a double blockade of cholinergic receptors had the same ameliorating effect on long-term memory deficits as low dose. Our data suggest that the antiamnesic effect of nicotine can result from an action at nicotinic receptors subtypes not blocked by chlorisondamine or at nonnicotinic receptors.
AB - In normal rats, muscarinic acetylcholine receptors (mAChRs) have a facilitating role on both short-term and long-term memory tested by Y-maze task and multi-trial passive avoidance test, respectively, since scopolamine, a specific mAChRs antagonist, impairs both types of memory. A low dose of nicotine (0.3 mg/kg b.w., i.p.), a specific nicotinic acetylcholine receptors (nAChRs) agonist, administered once caused a significant facilitating effect on short-term memory. A higher dose of nicotine (3 mg/kg b.w., i.p.) administered 5 consecutively days had about the same facilitating effect on short- and long-term memory without affecting information acquisition. In rats, having mAChRs and nAChRs blocked by means of scopolamine and chlorisondamine respectively, a low dose of nicotine administered once caused a significant improvement of long-term memory deficits without affecting significantly short-term memory. A higher dose of nicotine administered 5 consecutive days in rats with a double blockade of cholinergic receptors had the same ameliorating effect on long-term memory deficits as low dose. Our data suggest that the antiamnesic effect of nicotine can result from an action at nicotinic receptors subtypes not blocked by chlorisondamine or at nonnicotinic receptors.
UR - http://www.scopus.com/inward/record.url?scp=23944519979&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=23944519979&partnerID=8YFLogxK
M3 - Article
C2 - 15984653
AN - SCOPUS:23944519979
VL - 41
SP - 21
EP - 30
JO - Romanian journal of physiology : physiological sciences / [Academia de Stiinte Medicale]
JF - Romanian journal of physiology : physiological sciences / [Academia de Stiinte Medicale]
SN - 1223-4974
IS - 1-2
ER -