The Japan Multi-institutional Collaborative Cohort Study (JMICC Study) to detect gene-environment interactions for cancer

Nobuyuki Hamajima, Kenji Wakai, Mariko Naito, Kazuko Nishio, Yoshiko Ishida, Rieko Okada, Kaori Masui, Emi Morita, Tetsuo Kuroishi, Chiba Cohort, Haruo Mikami, Miki Ohira, Shuichi Fujimoto, Kimiko Takayama, Eiji Maruyama, Yuka Orii, Keiko Sato, Toru Masui, Kenji Matsui, Akiko Tamakoshi.Shuji Hashimoto, Kei Nakachi, Kazue Imai, Hidetaka Eguchi, Takashi Takahashi, Akira Okayama, Yoichi Kurosawa, Takeo Nakayama, Kaori Muto, Zentaro Yamagata, Yatami Asai, Masumi Suzuki, Hiroko Fukada, Akiko Tomoda, Yasoko Misu, Shiro Katase, Satoru Tokumasu, Yoko Kato, Murakami Yoichi, Koyama Atsushi, Kazuo Tajima, Kaoru Hirose, Akio Hiraki, Keitaro Matsuo, Takeshi Suzuki, Kiyonori Kuriki, Toshiko Saito, Miki Watanabe, Sadao Suzuki, Shinkan Tokudome, Akihiro Hosono, Kazuyuki Arakawa, Nami Hattori, Ryosuke Ando, Tsutomu Tanaka, Yukiko Kitabayashi, Hirotsugu Ueshima, Yoshikuni Kita, Yasuyuki Nakamura, Kenji Matsui, Takako Yamamoto, Turin Tanvir Chowdhury, Hideki Sugihara, Yutaka Morita, Nobuyoshi Tomioka, Yoshiyuki Watanabe, Kotaro Ozasa, Mariko Yuge, Kyohei Hayashi, Masako Shigeta, Satoko Mitani, Etsuko Ozaki, Daisuke Matsui, Tomio Sakazaki, Kokichi Arisawa, Hirokazu Uemura, Mineyoshi Hiyoshi, Yasunobu Sagara, Suminori Kono, Guang Yin, Jun Nagano, Tetsuya Mizoue, Ryoichi Takayanagi, Keizo Ohnaka, Hisaya Kawate, Masahiro Adachi, Malcolm A. Moore, Kengo Toyomura, Kayoko Isomura, Tomoko Hagiwara, Jin Fukumoto, Akiko Nanri, Taiki Yamaji, Daigo Yoshida, Makiko Morita, Naoyuki Ueda, Takako Maki, Mizuko Ikeda, Keitaro Tanaka, Koichi Shinchi, Yasuki Higaki, Megumi Hara, Tatsuhiko Sakamoto, Takeshi Imaizumi, Naoto Taguchi, Mikako Horita, Toshiro Takezaki, Hideshi Niimura, Kazuyo Hirasada, Masaya Tatebou, Tsunematsu Noriko, Ken Kus

Research output: Contribution to journalComment/debate

128 Citations (Scopus)

Abstract

The Japan Multi-institutional Collaborative Cohort Study (J-MICC Study) launched in 2005, supported by a research grant for Scientific Research on Special Priority Areas of Cancer from the Japanese Ministry of Education, Culture, Sports, Science and Technology. Although the main purpose is to confirm and detect gene-environment interactions of lifestyle-related diseases, mainly of cancer, through the cohort analyses, it includes cross-sectional analyses on lifestyle factors, biomarkers, and genotypes, as well as confirmation/screening of new biomarkers usable for early diagnosis of cancer. The endpoints are cancer diagnosis and death. The participants diagnosed as cancer will be identified through population-based cancer registries, hospital cancer registries, mail questionnaires, questionnaires at repeated visits, death certificates, health insurance data, and second survey questionnaires. Subjects are individuals aged 35 to 69 years enrolled from respondents to study announcements in specified areas, inhabitants attending health checkup examinations by local governments, visitors at health checkup centers, and patients at a cancer hospital. The number of subjects was set to be 100,000 throughout Japan. The enrollment period is from April 2005 to March 2010. The second survey is scheduled 5 years after their enrollment. The participants will be followed until 2025. The J-MICC Central Office is placed at Nagoya University Graduate School of Medicine. Ten participating research groups (Cohort Study Executing Groups) send baseline data and blood samples (buffy coat, serum, and plasma) anonymized with an identification number (J-MICC ID) to the Central Office. The data of second survey and follow-up will be linked using J-MICC ID. This study is expected to produce many findings on lifestyle and genetic traits associated with lifestyle-related diseases including cancer among Japanese.

Original languageEnglish
Pages (from-to)317-323
Number of pages7
JournalAsian Pacific Journal of Cancer Prevention
Volume8
Issue number2
Publication statusPublished - 01-01-2007

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Gene-Environment Interaction
Japan
Cohort Studies
Life Style
Cancer Care Facilities
Neoplasms
Registries
Blood Buffy Coat
Biomarkers
Research
Local Government
Community Health Nurses
Death Certificates
Organized Financing
Postal Service
Health Insurance
Early Detection of Cancer
Sports
Surveys and Questionnaires
Cross-Sectional Studies

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Oncology
  • Public Health, Environmental and Occupational Health
  • Cancer Research

Cite this

Hamajima, N., Wakai, K., Naito, M., Nishio, K., Ishida, Y., Okada, R., ... Kus, K. (2007). The Japan Multi-institutional Collaborative Cohort Study (JMICC Study) to detect gene-environment interactions for cancer. Asian Pacific Journal of Cancer Prevention, 8(2), 317-323.
Hamajima, Nobuyuki ; Wakai, Kenji ; Naito, Mariko ; Nishio, Kazuko ; Ishida, Yoshiko ; Okada, Rieko ; Masui, Kaori ; Morita, Emi ; Kuroishi, Tetsuo ; Cohort, Chiba ; Mikami, Haruo ; Ohira, Miki ; Fujimoto, Shuichi ; Takayama, Kimiko ; Maruyama, Eiji ; Orii, Yuka ; Sato, Keiko ; Masui, Toru ; Matsui, Kenji ; Tamakoshi., Akiko ; Hashimoto, Shuji ; Nakachi, Kei ; Imai, Kazue ; Eguchi, Hidetaka ; Takahashi, Takashi ; Okayama, Akira ; Kurosawa, Yoichi ; Nakayama, Takeo ; Muto, Kaori ; Yamagata, Zentaro ; Asai, Yatami ; Suzuki, Masumi ; Fukada, Hiroko ; Tomoda, Akiko ; Misu, Yasoko ; Katase, Shiro ; Tokumasu, Satoru ; Kato, Yoko ; Yoichi, Murakami ; Atsushi, Koyama ; Tajima, Kazuo ; Hirose, Kaoru ; Hiraki, Akio ; Matsuo, Keitaro ; Suzuki, Takeshi ; Kuriki, Kiyonori ; Saito, Toshiko ; Watanabe, Miki ; Suzuki, Sadao ; Tokudome, Shinkan ; Hosono, Akihiro ; Arakawa, Kazuyuki ; Hattori, Nami ; Ando, Ryosuke ; Tanaka, Tsutomu ; Kitabayashi, Yukiko ; Ueshima, Hirotsugu ; Kita, Yoshikuni ; Nakamura, Yasuyuki ; Matsui, Kenji ; Yamamoto, Takako ; Chowdhury, Turin Tanvir ; Sugihara, Hideki ; Morita, Yutaka ; Tomioka, Nobuyoshi ; Watanabe, Yoshiyuki ; Ozasa, Kotaro ; Yuge, Mariko ; Hayashi, Kyohei ; Shigeta, Masako ; Mitani, Satoko ; Ozaki, Etsuko ; Matsui, Daisuke ; Sakazaki, Tomio ; Arisawa, Kokichi ; Uemura, Hirokazu ; Hiyoshi, Mineyoshi ; Sagara, Yasunobu ; Kono, Suminori ; Yin, Guang ; Nagano, Jun ; Mizoue, Tetsuya ; Takayanagi, Ryoichi ; Ohnaka, Keizo ; Kawate, Hisaya ; Adachi, Masahiro ; Moore, Malcolm A. ; Toyomura, Kengo ; Isomura, Kayoko ; Hagiwara, Tomoko ; Fukumoto, Jin ; Nanri, Akiko ; Yamaji, Taiki ; Yoshida, Daigo ; Morita, Makiko ; Ueda, Naoyuki ; Maki, Takako ; Ikeda, Mizuko ; Tanaka, Keitaro ; Shinchi, Koichi ; Higaki, Yasuki ; Hara, Megumi ; Sakamoto, Tatsuhiko ; Imaizumi, Takeshi ; Taguchi, Naoto ; Horita, Mikako ; Takezaki, Toshiro ; Niimura, Hideshi ; Hirasada, Kazuyo ; Tatebou, Masaya ; Noriko, Tsunematsu ; Kus, Ken. / The Japan Multi-institutional Collaborative Cohort Study (JMICC Study) to detect gene-environment interactions for cancer. In: Asian Pacific Journal of Cancer Prevention. 2007 ; Vol. 8, No. 2. pp. 317-323.
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title = "The Japan Multi-institutional Collaborative Cohort Study (JMICC Study) to detect gene-environment interactions for cancer",
abstract = "The Japan Multi-institutional Collaborative Cohort Study (J-MICC Study) launched in 2005, supported by a research grant for Scientific Research on Special Priority Areas of Cancer from the Japanese Ministry of Education, Culture, Sports, Science and Technology. Although the main purpose is to confirm and detect gene-environment interactions of lifestyle-related diseases, mainly of cancer, through the cohort analyses, it includes cross-sectional analyses on lifestyle factors, biomarkers, and genotypes, as well as confirmation/screening of new biomarkers usable for early diagnosis of cancer. The endpoints are cancer diagnosis and death. The participants diagnosed as cancer will be identified through population-based cancer registries, hospital cancer registries, mail questionnaires, questionnaires at repeated visits, death certificates, health insurance data, and second survey questionnaires. Subjects are individuals aged 35 to 69 years enrolled from respondents to study announcements in specified areas, inhabitants attending health checkup examinations by local governments, visitors at health checkup centers, and patients at a cancer hospital. The number of subjects was set to be 100,000 throughout Japan. The enrollment period is from April 2005 to March 2010. The second survey is scheduled 5 years after their enrollment. The participants will be followed until 2025. The J-MICC Central Office is placed at Nagoya University Graduate School of Medicine. Ten participating research groups (Cohort Study Executing Groups) send baseline data and blood samples (buffy coat, serum, and plasma) anonymized with an identification number (J-MICC ID) to the Central Office. The data of second survey and follow-up will be linked using J-MICC ID. This study is expected to produce many findings on lifestyle and genetic traits associated with lifestyle-related diseases including cancer among Japanese.",
author = "Nobuyuki Hamajima and Kenji Wakai and Mariko Naito and Kazuko Nishio and Yoshiko Ishida and Rieko Okada and Kaori Masui and Emi Morita and Tetsuo Kuroishi and Chiba Cohort and Haruo Mikami and Miki Ohira and Shuichi Fujimoto and Kimiko Takayama and Eiji Maruyama and Yuka Orii and Keiko Sato and Toru Masui and Kenji Matsui and Akiko Tamakoshi. and Shuji Hashimoto and Kei Nakachi and Kazue Imai and Hidetaka Eguchi and Takashi Takahashi and Akira Okayama and Yoichi Kurosawa and Takeo Nakayama and Kaori Muto and Zentaro Yamagata and Yatami Asai and Masumi Suzuki and Hiroko Fukada and Akiko Tomoda and Yasoko Misu and Shiro Katase and Satoru Tokumasu and Yoko Kato and Murakami Yoichi and Koyama Atsushi and Kazuo Tajima and Kaoru Hirose and Akio Hiraki and Keitaro Matsuo and Takeshi Suzuki and Kiyonori Kuriki and Toshiko Saito and Miki Watanabe and Sadao Suzuki and Shinkan Tokudome and Akihiro Hosono and Kazuyuki Arakawa and Nami Hattori and Ryosuke Ando and Tsutomu Tanaka and Yukiko Kitabayashi and Hirotsugu Ueshima and Yoshikuni Kita and Yasuyuki Nakamura and Kenji Matsui and Takako Yamamoto and Chowdhury, {Turin Tanvir} and Hideki Sugihara and Yutaka Morita and Nobuyoshi Tomioka and Yoshiyuki Watanabe and Kotaro Ozasa and Mariko Yuge and Kyohei Hayashi and Masako Shigeta and Satoko Mitani and Etsuko Ozaki and Daisuke Matsui and Tomio Sakazaki and Kokichi Arisawa and Hirokazu Uemura and Mineyoshi Hiyoshi and Yasunobu Sagara and Suminori Kono and Guang Yin and Jun Nagano and Tetsuya Mizoue and Ryoichi Takayanagi and Keizo Ohnaka and Hisaya Kawate and Masahiro Adachi and Moore, {Malcolm A.} and Kengo Toyomura and Kayoko Isomura and Tomoko Hagiwara and Jin Fukumoto and Akiko Nanri and Taiki Yamaji and Daigo Yoshida and Makiko Morita and Naoyuki Ueda and Takako Maki and Mizuko Ikeda and Keitaro Tanaka and Koichi Shinchi and Yasuki Higaki and Megumi Hara and Tatsuhiko Sakamoto and Takeshi Imaizumi and Naoto Taguchi and Mikako Horita and Toshiro Takezaki and Hideshi Niimura and Kazuyo Hirasada and Masaya Tatebou and Tsunematsu Noriko and Ken Kus",
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Hamajima, N, Wakai, K, Naito, M, Nishio, K, Ishida, Y, Okada, R, Masui, K, Morita, E, Kuroishi, T, Cohort, C, Mikami, H, Ohira, M, Fujimoto, S, Takayama, K, Maruyama, E, Orii, Y, Sato, K, Masui, T, Matsui, K, Tamakoshi., A, Hashimoto, S, Nakachi, K, Imai, K, Eguchi, H, Takahashi, T, Okayama, A, Kurosawa, Y, Nakayama, T, Muto, K, Yamagata, Z, Asai, Y, Suzuki, M, Fukada, H, Tomoda, A, Misu, Y, Katase, S, Tokumasu, S, Kato, Y, Yoichi, M, Atsushi, K, Tajima, K, Hirose, K, Hiraki, A, Matsuo, K, Suzuki, T, Kuriki, K, Saito, T, Watanabe, M, Suzuki, S, Tokudome, S, Hosono, A, Arakawa, K, Hattori, N, Ando, R, Tanaka, T, Kitabayashi, Y, Ueshima, H, Kita, Y, Nakamura, Y, Matsui, K, Yamamoto, T, Chowdhury, TT, Sugihara, H, Morita, Y, Tomioka, N, Watanabe, Y, Ozasa, K, Yuge, M, Hayashi, K, Shigeta, M, Mitani, S, Ozaki, E, Matsui, D, Sakazaki, T, Arisawa, K, Uemura, H, Hiyoshi, M, Sagara, Y, Kono, S, Yin, G, Nagano, J, Mizoue, T, Takayanagi, R, Ohnaka, K, Kawate, H, Adachi, M, Moore, MA, Toyomura, K, Isomura, K, Hagiwara, T, Fukumoto, J, Nanri, A, Yamaji, T, Yoshida, D, Morita, M, Ueda, N, Maki, T, Ikeda, M, Tanaka, K, Shinchi, K, Higaki, Y, Hara, M, Sakamoto, T, Imaizumi, T, Taguchi, N, Horita, M, Takezaki, T, Niimura, H, Hirasada, K, Tatebou, M, Noriko, T & Kus, K 2007, 'The Japan Multi-institutional Collaborative Cohort Study (JMICC Study) to detect gene-environment interactions for cancer', Asian Pacific Journal of Cancer Prevention, vol. 8, no. 2, pp. 317-323.

The Japan Multi-institutional Collaborative Cohort Study (JMICC Study) to detect gene-environment interactions for cancer. / Hamajima, Nobuyuki; Wakai, Kenji; Naito, Mariko; Nishio, Kazuko; Ishida, Yoshiko; Okada, Rieko; Masui, Kaori; Morita, Emi; Kuroishi, Tetsuo; Cohort, Chiba; Mikami, Haruo; Ohira, Miki; Fujimoto, Shuichi; Takayama, Kimiko; Maruyama, Eiji; Orii, Yuka; Sato, Keiko; Masui, Toru; Matsui, Kenji; Tamakoshi., Akiko; Hashimoto, Shuji; Nakachi, Kei; Imai, Kazue; Eguchi, Hidetaka; Takahashi, Takashi; Okayama, Akira; Kurosawa, Yoichi; Nakayama, Takeo; Muto, Kaori; Yamagata, Zentaro; Asai, Yatami; Suzuki, Masumi; Fukada, Hiroko; Tomoda, Akiko; Misu, Yasoko; Katase, Shiro; Tokumasu, Satoru; Kato, Yoko; Yoichi, Murakami; Atsushi, Koyama; Tajima, Kazuo; Hirose, Kaoru; Hiraki, Akio; Matsuo, Keitaro; Suzuki, Takeshi; Kuriki, Kiyonori; Saito, Toshiko; Watanabe, Miki; Suzuki, Sadao; Tokudome, Shinkan; Hosono, Akihiro; Arakawa, Kazuyuki; Hattori, Nami; Ando, Ryosuke; Tanaka, Tsutomu; Kitabayashi, Yukiko; Ueshima, Hirotsugu; Kita, Yoshikuni; Nakamura, Yasuyuki; Matsui, Kenji; Yamamoto, Takako; Chowdhury, Turin Tanvir; Sugihara, Hideki; Morita, Yutaka; Tomioka, Nobuyoshi; Watanabe, Yoshiyuki; Ozasa, Kotaro; Yuge, Mariko; Hayashi, Kyohei; Shigeta, Masako; Mitani, Satoko; Ozaki, Etsuko; Matsui, Daisuke; Sakazaki, Tomio; Arisawa, Kokichi; Uemura, Hirokazu; Hiyoshi, Mineyoshi; Sagara, Yasunobu; Kono, Suminori; Yin, Guang; Nagano, Jun; Mizoue, Tetsuya; Takayanagi, Ryoichi; Ohnaka, Keizo; Kawate, Hisaya; Adachi, Masahiro; Moore, Malcolm A.; Toyomura, Kengo; Isomura, Kayoko; Hagiwara, Tomoko; Fukumoto, Jin; Nanri, Akiko; Yamaji, Taiki; Yoshida, Daigo; Morita, Makiko; Ueda, Naoyuki; Maki, Takako; Ikeda, Mizuko; Tanaka, Keitaro; Shinchi, Koichi; Higaki, Yasuki; Hara, Megumi; Sakamoto, Tatsuhiko; Imaizumi, Takeshi; Taguchi, Naoto; Horita, Mikako; Takezaki, Toshiro; Niimura, Hideshi; Hirasada, Kazuyo; Tatebou, Masaya; Noriko, Tsunematsu; Kus, Ken.

In: Asian Pacific Journal of Cancer Prevention, Vol. 8, No. 2, 01.01.2007, p. 317-323.

Research output: Contribution to journalComment/debate

TY - JOUR

T1 - The Japan Multi-institutional Collaborative Cohort Study (JMICC Study) to detect gene-environment interactions for cancer

AU - Hamajima, Nobuyuki

AU - Wakai, Kenji

AU - Naito, Mariko

AU - Nishio, Kazuko

AU - Ishida, Yoshiko

AU - Okada, Rieko

AU - Masui, Kaori

AU - Morita, Emi

AU - Kuroishi, Tetsuo

AU - Cohort, Chiba

AU - Mikami, Haruo

AU - Ohira, Miki

AU - Fujimoto, Shuichi

AU - Takayama, Kimiko

AU - Maruyama, Eiji

AU - Orii, Yuka

AU - Sato, Keiko

AU - Masui, Toru

AU - Matsui, Kenji

AU - Tamakoshi., Akiko

AU - Hashimoto, Shuji

AU - Nakachi, Kei

AU - Imai, Kazue

AU - Eguchi, Hidetaka

AU - Takahashi, Takashi

AU - Okayama, Akira

AU - Kurosawa, Yoichi

AU - Nakayama, Takeo

AU - Muto, Kaori

AU - Yamagata, Zentaro

AU - Asai, Yatami

AU - Suzuki, Masumi

AU - Fukada, Hiroko

AU - Tomoda, Akiko

AU - Misu, Yasoko

AU - Katase, Shiro

AU - Tokumasu, Satoru

AU - Kato, Yoko

AU - Yoichi, Murakami

AU - Atsushi, Koyama

AU - Tajima, Kazuo

AU - Hirose, Kaoru

AU - Hiraki, Akio

AU - Matsuo, Keitaro

AU - Suzuki, Takeshi

AU - Kuriki, Kiyonori

AU - Saito, Toshiko

AU - Watanabe, Miki

AU - Suzuki, Sadao

AU - Tokudome, Shinkan

AU - Hosono, Akihiro

AU - Arakawa, Kazuyuki

AU - Hattori, Nami

AU - Ando, Ryosuke

AU - Tanaka, Tsutomu

AU - Kitabayashi, Yukiko

AU - Ueshima, Hirotsugu

AU - Kita, Yoshikuni

AU - Nakamura, Yasuyuki

AU - Matsui, Kenji

AU - Yamamoto, Takako

AU - Chowdhury, Turin Tanvir

AU - Sugihara, Hideki

AU - Morita, Yutaka

AU - Tomioka, Nobuyoshi

AU - Watanabe, Yoshiyuki

AU - Ozasa, Kotaro

AU - Yuge, Mariko

AU - Hayashi, Kyohei

AU - Shigeta, Masako

AU - Mitani, Satoko

AU - Ozaki, Etsuko

AU - Matsui, Daisuke

AU - Sakazaki, Tomio

AU - Arisawa, Kokichi

AU - Uemura, Hirokazu

AU - Hiyoshi, Mineyoshi

AU - Sagara, Yasunobu

AU - Kono, Suminori

AU - Yin, Guang

AU - Nagano, Jun

AU - Mizoue, Tetsuya

AU - Takayanagi, Ryoichi

AU - Ohnaka, Keizo

AU - Kawate, Hisaya

AU - Adachi, Masahiro

AU - Moore, Malcolm A.

AU - Toyomura, Kengo

AU - Isomura, Kayoko

AU - Hagiwara, Tomoko

AU - Fukumoto, Jin

AU - Nanri, Akiko

AU - Yamaji, Taiki

AU - Yoshida, Daigo

AU - Morita, Makiko

AU - Ueda, Naoyuki

AU - Maki, Takako

AU - Ikeda, Mizuko

AU - Tanaka, Keitaro

AU - Shinchi, Koichi

AU - Higaki, Yasuki

AU - Hara, Megumi

AU - Sakamoto, Tatsuhiko

AU - Imaizumi, Takeshi

AU - Taguchi, Naoto

AU - Horita, Mikako

AU - Takezaki, Toshiro

AU - Niimura, Hideshi

AU - Hirasada, Kazuyo

AU - Tatebou, Masaya

AU - Noriko, Tsunematsu

AU - Kus, Ken

PY - 2007/1/1

Y1 - 2007/1/1

N2 - The Japan Multi-institutional Collaborative Cohort Study (J-MICC Study) launched in 2005, supported by a research grant for Scientific Research on Special Priority Areas of Cancer from the Japanese Ministry of Education, Culture, Sports, Science and Technology. Although the main purpose is to confirm and detect gene-environment interactions of lifestyle-related diseases, mainly of cancer, through the cohort analyses, it includes cross-sectional analyses on lifestyle factors, biomarkers, and genotypes, as well as confirmation/screening of new biomarkers usable for early diagnosis of cancer. The endpoints are cancer diagnosis and death. The participants diagnosed as cancer will be identified through population-based cancer registries, hospital cancer registries, mail questionnaires, questionnaires at repeated visits, death certificates, health insurance data, and second survey questionnaires. Subjects are individuals aged 35 to 69 years enrolled from respondents to study announcements in specified areas, inhabitants attending health checkup examinations by local governments, visitors at health checkup centers, and patients at a cancer hospital. The number of subjects was set to be 100,000 throughout Japan. The enrollment period is from April 2005 to March 2010. The second survey is scheduled 5 years after their enrollment. The participants will be followed until 2025. The J-MICC Central Office is placed at Nagoya University Graduate School of Medicine. Ten participating research groups (Cohort Study Executing Groups) send baseline data and blood samples (buffy coat, serum, and plasma) anonymized with an identification number (J-MICC ID) to the Central Office. The data of second survey and follow-up will be linked using J-MICC ID. This study is expected to produce many findings on lifestyle and genetic traits associated with lifestyle-related diseases including cancer among Japanese.

AB - The Japan Multi-institutional Collaborative Cohort Study (J-MICC Study) launched in 2005, supported by a research grant for Scientific Research on Special Priority Areas of Cancer from the Japanese Ministry of Education, Culture, Sports, Science and Technology. Although the main purpose is to confirm and detect gene-environment interactions of lifestyle-related diseases, mainly of cancer, through the cohort analyses, it includes cross-sectional analyses on lifestyle factors, biomarkers, and genotypes, as well as confirmation/screening of new biomarkers usable for early diagnosis of cancer. The endpoints are cancer diagnosis and death. The participants diagnosed as cancer will be identified through population-based cancer registries, hospital cancer registries, mail questionnaires, questionnaires at repeated visits, death certificates, health insurance data, and second survey questionnaires. Subjects are individuals aged 35 to 69 years enrolled from respondents to study announcements in specified areas, inhabitants attending health checkup examinations by local governments, visitors at health checkup centers, and patients at a cancer hospital. The number of subjects was set to be 100,000 throughout Japan. The enrollment period is from April 2005 to March 2010. The second survey is scheduled 5 years after their enrollment. The participants will be followed until 2025. The J-MICC Central Office is placed at Nagoya University Graduate School of Medicine. Ten participating research groups (Cohort Study Executing Groups) send baseline data and blood samples (buffy coat, serum, and plasma) anonymized with an identification number (J-MICC ID) to the Central Office. The data of second survey and follow-up will be linked using J-MICC ID. This study is expected to produce many findings on lifestyle and genetic traits associated with lifestyle-related diseases including cancer among Japanese.

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UR - http://www.scopus.com/inward/citedby.url?scp=40449117476&partnerID=8YFLogxK

M3 - Comment/debate

C2 - 17696755

AN - SCOPUS:40449117476

VL - 8

SP - 317

EP - 323

JO - Asian Pacific Journal of Cancer Prevention

JF - Asian Pacific Journal of Cancer Prevention

SN - 1513-7368

IS - 2

ER -