The Japanese Histologic Classification and T-score in the Oxford Classification system could predict renal outcome in Japanese IgA nephropathy patients

Ahmad Baseer Kaihan, Yoshinari Yasuda, Takayuki Katsuno, Sawako Kato, Takahiro Imaizumi, Takaya Ozeki, Manabu Hishida, Takanobu Nagata, Masahiko Ando, Naotake Tsuboi, Shoichi Maruyama

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: The Oxford Classification is utilized globally, but has not been fully validated. In this study, we conducted a comparative analysis between the Oxford Classification and Japanese Histologic Classification (JHC) to predict renal outcome in Japanese patients with IgA nephropathy (IgAN). Methods: A retrospective cohort study including 86 adult IgAN patients was conducted. The Oxford Classification and the JHC were evaluated by 7 independent specialists. The JHC, MEST score in the Oxford Classification, and crescents were analyzed in association with renal outcome, defined as a 50% increase in serum creatinine. Results: In multivariate analysis without the JHC, only the T score was significantly associated with renal outcome. While, a significant association was revealed only in the JHC on multivariate analysis with JHC. Conclusions: The JHC and T score in the Oxford Classification were associated with renal outcome among Japanese patients with IgAN. Superiority of the JHC as a predictive index should be validated with larger study population and cohort studies in different ethnicities.

Original languageEnglish
Pages (from-to)986-994
Number of pages9
JournalClinical and Experimental Nephrology
Volume21
Issue number6
DOIs
Publication statusPublished - 01-12-2017
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Physiology
  • Nephrology
  • Physiology (medical)

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