TY - JOUR
T1 - The Japanese Histologic Classification and T-score in the Oxford Classification system could predict renal outcome in Japanese IgA nephropathy patients
AU - Kaihan, Ahmad Baseer
AU - Yasuda, Yoshinari
AU - Katsuno, Takayuki
AU - Kato, Sawako
AU - Imaizumi, Takahiro
AU - Ozeki, Takaya
AU - Hishida, Manabu
AU - Nagata, Takanobu
AU - Ando, Masahiko
AU - Tsuboi, Naotake
AU - Maruyama, Shoichi
N1 - Funding Information:
Conflict of interest The Department of Nephrology, Nagoya University Graduate School of Medicine received research promotion grants from Astellas, Alexion, Otsuka, Kyowa Hakko Kirin, Daiichi Sankyo, Dainippon Sumitomo, Takeda, Torii, Pfizer, and Mochida. Department of CKD Initiatives, Nagoya University Graduate School of Medicine received donation from MSD, Dainippon Sumitomo, Ky-owa Hakko Kirin, Kowa, Chugai, Boehringer Ingelheim, Nihon Medi-Physics Co.,Ltd. and research promotion grants from Daiichi Sankyo, Takeda, Torii, Astellas, and Shionogi.
Funding Information:
Acknowledgements This study was supported in part by a Grant-in-Aid for Progressive Renal Diseases Research, Research on Rare and Intractable Disease, from the Ministry of Health, Labour and Welfare of Japan.
Funding Information:
This study was supported in part by a Grant-in-Aid for Progressive Renal Diseases Research, Research on Rare and Intractable Disease, from the Ministry of Health, Labour and Welfare of Japan. The Department of Nephrology, Nagoya University Graduate School of Medicine received research promotion grants from Astellas, Alexion, Otsuka, Kyowa Hakko Kirin, Daiichi Sankyo, Dainippon Sumitomo, Takeda, Torii, Pfizer, and Mochida. Department of CKD Initiatives, Nagoya University Graduate School of Medicine received donation from MSD, Dainippon Sumitomo, Kyowa Hakko Kirin, Kowa, Chugai, Boehringer Ingelheim, Nihon Medi-Physics Co.,Ltd. and research promotion grants from Daiichi Sankyo, Takeda, Torii, Astellas, and Shionogi.
PY - 2017/12/1
Y1 - 2017/12/1
N2 - Background: The Oxford Classification is utilized globally, but has not been fully validated. In this study, we conducted a comparative analysis between the Oxford Classification and Japanese Histologic Classification (JHC) to predict renal outcome in Japanese patients with IgA nephropathy (IgAN). Methods: A retrospective cohort study including 86 adult IgAN patients was conducted. The Oxford Classification and the JHC were evaluated by 7 independent specialists. The JHC, MEST score in the Oxford Classification, and crescents were analyzed in association with renal outcome, defined as a 50% increase in serum creatinine. Results: In multivariate analysis without the JHC, only the T score was significantly associated with renal outcome. While, a significant association was revealed only in the JHC on multivariate analysis with JHC. Conclusions: The JHC and T score in the Oxford Classification were associated with renal outcome among Japanese patients with IgAN. Superiority of the JHC as a predictive index should be validated with larger study population and cohort studies in different ethnicities.
AB - Background: The Oxford Classification is utilized globally, but has not been fully validated. In this study, we conducted a comparative analysis between the Oxford Classification and Japanese Histologic Classification (JHC) to predict renal outcome in Japanese patients with IgA nephropathy (IgAN). Methods: A retrospective cohort study including 86 adult IgAN patients was conducted. The Oxford Classification and the JHC were evaluated by 7 independent specialists. The JHC, MEST score in the Oxford Classification, and crescents were analyzed in association with renal outcome, defined as a 50% increase in serum creatinine. Results: In multivariate analysis without the JHC, only the T score was significantly associated with renal outcome. While, a significant association was revealed only in the JHC on multivariate analysis with JHC. Conclusions: The JHC and T score in the Oxford Classification were associated with renal outcome among Japanese patients with IgAN. Superiority of the JHC as a predictive index should be validated with larger study population and cohort studies in different ethnicities.
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U2 - 10.1007/s10157-017-1393-x
DO - 10.1007/s10157-017-1393-x
M3 - Article
C2 - 28349230
AN - SCOPUS:85016096449
VL - 21
SP - 986
EP - 994
JO - Clinical and Experimental Nephrology
JF - Clinical and Experimental Nephrology
SN - 1342-1751
IS - 6
ER -