TY - JOUR
T1 - The long-lasting effects of cross-fostering on the emotional behavior in ICR mice
AU - Lu, Lingling
AU - Mamiya, Takayoshi
AU - Lu, Ping
AU - Niwa, Minae
AU - Mouri, Akihiro
AU - Zou, Li Bo
AU - Nagai, Taku
AU - Hiramatsu, Masayuki
AU - Nabeshima, Toshitaka
N1 - Funding Information:
This work was supported, in part, by Grants-in-Aid for “Academic Frontier Project for Private Universities (2007–2011) from the Ministry of Education, Culture, Sports, Science and Technology of Japan; Research on the Risk of Chemical Substances from the Ministry of Health, Labour and Welfare, Japan; the Japan France Joint Health Research Program (Joint Project from Japan Society for the Promotion of Science); and an International Research Project Supported by the Meijo Asian Research Center.
PY - 2009/3/2
Y1 - 2009/3/2
N2 - Early-life stress during the postnatal period could precipitate long-lasting alterations in the functional properties underlying emotional expression in humans, but how the psychological stress of cross-fostering affects emotional behavior during adulthood in mice remains primarily unknown. The purpose of the present study was to examine the long-term effects of cross-fostering on the emotional behavior and cognitive functions of ICR offspring in adulthood. Cross-fostering was performed from postnatal day 7 for 3 weeks. Mice were divided into three groups: (1) biological group: pups born from ICR dams fostered by their original mothers; (2) in-foster group: pups born from ICR dams but adopted by other ICR dams and (3) cross-foster group: ICR pups adopted by C57 dams. ICR mice were subjected to behavioral experiments at the age of 8 weeks. Emotional behaviors in the cross-fostered mice were significantly altered in the open-field, elevated plus maze and forced swimming tests, as well as social interaction tests. However, the cross-fostered mice showed normal memory function in the Y-maze and novel object recognition tests. The contents of serotonin metabolisms were decreased in the prefrontal cortex and hippocampus indicated the deficit of serotoninergic neuronal function by cross-fostering. These findings suggested that the early-life stress of cross-fostering induced long-lasting emotional abnormalities, which might be possibly related to alterations of serotonin metabolisms.
AB - Early-life stress during the postnatal period could precipitate long-lasting alterations in the functional properties underlying emotional expression in humans, but how the psychological stress of cross-fostering affects emotional behavior during adulthood in mice remains primarily unknown. The purpose of the present study was to examine the long-term effects of cross-fostering on the emotional behavior and cognitive functions of ICR offspring in adulthood. Cross-fostering was performed from postnatal day 7 for 3 weeks. Mice were divided into three groups: (1) biological group: pups born from ICR dams fostered by their original mothers; (2) in-foster group: pups born from ICR dams but adopted by other ICR dams and (3) cross-foster group: ICR pups adopted by C57 dams. ICR mice were subjected to behavioral experiments at the age of 8 weeks. Emotional behaviors in the cross-fostered mice were significantly altered in the open-field, elevated plus maze and forced swimming tests, as well as social interaction tests. However, the cross-fostered mice showed normal memory function in the Y-maze and novel object recognition tests. The contents of serotonin metabolisms were decreased in the prefrontal cortex and hippocampus indicated the deficit of serotoninergic neuronal function by cross-fostering. These findings suggested that the early-life stress of cross-fostering induced long-lasting emotional abnormalities, which might be possibly related to alterations of serotonin metabolisms.
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U2 - 10.1016/j.bbr.2008.10.031
DO - 10.1016/j.bbr.2008.10.031
M3 - Article
C2 - 19027040
AN - SCOPUS:58549087717
SN - 0166-4328
VL - 198
SP - 172
EP - 178
JO - Behavioural Brain Research
JF - Behavioural Brain Research
IS - 1
ER -