The mean circulatory pressure, reproducibility of its measurements and the effect of phenylephrine with a note on the effect of pentobarbital

Senri Hirakawa; Hiroyasu Ito; Yasushi Kondo; Ikuo Watanabe; Kunihiko Hiei; Shohachi Banno; Shoji Hayase

doi:10.1253/jcj.39.403

The mean circulatory pressure, reproducibility of its measurements and the effect of phenylephrine with a note on the effect of pentobarbital

Senri Hirakawa, Hiroyasu Ito, Yasushi Kondo, Ikuo Watanabe, Kunihiko Hiei, Shohachi Banno, Shoji Hayase

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

With 7 repeated measurements of the mean circulatory pressure (MCP) over a course of 35 minutes in one and the same dog, and also with paired measurements of MCP 10 minutes apart in 6 other dogs, the MCP was shown to be stable and reproducible in anesthetized, open-chest and vagus-intact dogs. Administered to 7 dogs with initial mean arterial blood pressure as low as 64 mmHg in dose of 20 μg/kg intravenously, phenylephrine nearly doubled the mean arterial blood pressure, total peripheral resistance and the MCP, indicating a marked vasoconstrictor effect on the resistance and capacitance blood vessels of the systemic circulation. The effect was transient and there were signs of tachyphylaxis. Influence of a cardiotoxic dose of pentobarbital on the peripheral circulation was discussed.

Original language	English
Pages (from-to)	403-409
Number of pages	7
Journal	JAPANESE CIRCULATION JOURNAL
Volume	39
Issue number	4
DOIs	https://doi.org/10.1253/jcj.39.403
Publication status	Published - 1975
Externally published	Yes

All Science Journal Classification (ASJC) codes

Physiology
Cardiology and Cardiovascular Medicine

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10.1253/jcj.39.403

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abstract = "With 7 repeated measurements of the mean circulatory pressure (MCP) over a course of 35 minutes in one and the same dog, and also with paired measurements of MCP 10 minutes apart in 6 other dogs, the MCP was shown to be stable and reproducible in anesthetized, open-chest and vagus-intact dogs. Administered to 7 dogs with initial mean arterial blood pressure as low as 64 mmHg in dose of 20 μg/kg intravenously, phenylephrine nearly doubled the mean arterial blood pressure, total peripheral resistance and the MCP, indicating a marked vasoconstrictor effect on the resistance and capacitance blood vessels of the systemic circulation. The effect was transient and there were signs of tachyphylaxis. Influence of a cardiotoxic dose of pentobarbital on the peripheral circulation was discussed.",

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T1 - The mean circulatory pressure, reproducibility of its measurements and the effect of phenylephrine with a note on the effect of pentobarbital

AU - Hirakawa, Senri

AU - Ito, Hiroyasu

AU - Kondo, Yasushi

AU - Watanabe, Ikuo

AU - Hiei, Kunihiko

AU - Banno, Shohachi

AU - Hayase, Shoji

PY - 1975

Y1 - 1975

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AB - With 7 repeated measurements of the mean circulatory pressure (MCP) over a course of 35 minutes in one and the same dog, and also with paired measurements of MCP 10 minutes apart in 6 other dogs, the MCP was shown to be stable and reproducible in anesthetized, open-chest and vagus-intact dogs. Administered to 7 dogs with initial mean arterial blood pressure as low as 64 mmHg in dose of 20 μg/kg intravenously, phenylephrine nearly doubled the mean arterial blood pressure, total peripheral resistance and the MCP, indicating a marked vasoconstrictor effect on the resistance and capacitance blood vessels of the systemic circulation. The effect was transient and there were signs of tachyphylaxis. Influence of a cardiotoxic dose of pentobarbital on the peripheral circulation was discussed.

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The mean circulatory pressure, reproducibility of its measurements and the effect of phenylephrine with a note on the effect of pentobarbital

Abstract

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