The mechanism, diagnosis and treatment of HHV-6B encephalitis

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Human herpesvirus 6B (HHV-6B) is causative agent for exanthem subitum, which is common febrile illness in infant. This disease is generally benign and self-limited disease, however rarely causes several central nervous system complications. As various types of HHV-6B encephalitis has been demonstrated, pathophysiology of the disease would be complicate. Thus, different therapeutic strategies should be established for each type of HHV-6B encephalitis at the time of primary viral infection. Meanwhile, this virus can reactivate in transplant recipients and cause post-trasplant limbic encephalitis. It has been demonstrated that neuroimaging analysis particularly MRI image is useful for diagnosis of post-transplant HHV-6B encephalitis. As high copies of viral DNA are detected in patient's CSF, direct invasion of HHV-6B might play important role in causing the disease. Ganciclovir or foscarnet could be effective against HHV-6B based on in vitro analysis.

Original languageEnglish
Pages (from-to)1372-1374
Number of pages3
JournalClinical Neurology
Volume52
Issue number11
DOIs
Publication statusPublished - 01-12-2012

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Human Herpesvirus 6
Encephalitis
Therapeutics
Limbic Encephalitis
Foscarnet
Ganciclovir
Viral DNA
Virus Diseases
Exanthema
Neuroimaging
Fever
Central Nervous System
Viruses
Transplants

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

Cite this

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title = "The mechanism, diagnosis and treatment of HHV-6B encephalitis",
abstract = "Human herpesvirus 6B (HHV-6B) is causative agent for exanthem subitum, which is common febrile illness in infant. This disease is generally benign and self-limited disease, however rarely causes several central nervous system complications. As various types of HHV-6B encephalitis has been demonstrated, pathophysiology of the disease would be complicate. Thus, different therapeutic strategies should be established for each type of HHV-6B encephalitis at the time of primary viral infection. Meanwhile, this virus can reactivate in transplant recipients and cause post-trasplant limbic encephalitis. It has been demonstrated that neuroimaging analysis particularly MRI image is useful for diagnosis of post-transplant HHV-6B encephalitis. As high copies of viral DNA are detected in patient's CSF, direct invasion of HHV-6B might play important role in causing the disease. Ganciclovir or foscarnet could be effective against HHV-6B based on in vitro analysis.",
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The mechanism, diagnosis and treatment of HHV-6B encephalitis. / Yoshikawa, Tetsushi.

In: Clinical Neurology, Vol. 52, No. 11, 01.12.2012, p. 1372-1374.

Research output: Contribution to journalArticle

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