The mechanisms for latency and reactivation of alpha herpesviridae

Research output: Contribution to journalReview article

Abstract

Alpha herpesviridae (herpes simplex virus, HSV and varicella zoster virus, VZV) is a neurotropic phathogen of humans that establishes latent infection in the sensory ganglia, and periodically reactivates from latently infected neurons. Most of basic research for analyzing the mechanism of latency and reactivation of herpes viruses has been carried out in HSV. According to the results from the molecular analysis in the neurons latently infected with HSV, during latency, the virus genome is quiescent, except for the transcription of the latency associated transcripts (LATs). Thus, it has been considered that LATs play an important role for latency and reactivation of the virus. It has been shown that LATs are required for efficient reactivation from latency in vivo, and regulate the site specificity for reactivation of the virus. Recent studies demonstrated that the quantities of latent virus are correlated with the frequency of reactivation of the virus. Moreover, it was suggested that the latency-related gene of bovine herpesvirus 1 could inhibit the apoptosis of the several cells including neuronal cells.

Original languageEnglish
Pages (from-to)807-814
Number of pages8
JournalNippon rinsho. Japanese journal of clinical medicine
Volume58
Issue number4
Publication statusPublished - 01-01-2000
Externally publishedYes

Fingerprint

Herpesviridae
Virus Latency
Viruses
Bovine Herpesvirus 1
Sensory Ganglia
Neurons
Human Herpesvirus 3
Simplexvirus
Genome
Apoptosis
Infection
Research
Genes

Cite this

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title = "The mechanisms for latency and reactivation of alpha herpesviridae",
abstract = "Alpha herpesviridae (herpes simplex virus, HSV and varicella zoster virus, VZV) is a neurotropic phathogen of humans that establishes latent infection in the sensory ganglia, and periodically reactivates from latently infected neurons. Most of basic research for analyzing the mechanism of latency and reactivation of herpes viruses has been carried out in HSV. According to the results from the molecular analysis in the neurons latently infected with HSV, during latency, the virus genome is quiescent, except for the transcription of the latency associated transcripts (LATs). Thus, it has been considered that LATs play an important role for latency and reactivation of the virus. It has been shown that LATs are required for efficient reactivation from latency in vivo, and regulate the site specificity for reactivation of the virus. Recent studies demonstrated that the quantities of latent virus are correlated with the frequency of reactivation of the virus. Moreover, it was suggested that the latency-related gene of bovine herpesvirus 1 could inhibit the apoptosis of the several cells including neuronal cells.",
author = "Tetsushi Yoshikawa",
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The mechanisms for latency and reactivation of alpha herpesviridae. / Yoshikawa, Tetsushi.

In: Nippon rinsho. Japanese journal of clinical medicine, Vol. 58, No. 4, 01.01.2000, p. 807-814.

Research output: Contribution to journalReview article

TY - JOUR

T1 - The mechanisms for latency and reactivation of alpha herpesviridae

AU - Yoshikawa, Tetsushi

PY - 2000/1/1

Y1 - 2000/1/1

N2 - Alpha herpesviridae (herpes simplex virus, HSV and varicella zoster virus, VZV) is a neurotropic phathogen of humans that establishes latent infection in the sensory ganglia, and periodically reactivates from latently infected neurons. Most of basic research for analyzing the mechanism of latency and reactivation of herpes viruses has been carried out in HSV. According to the results from the molecular analysis in the neurons latently infected with HSV, during latency, the virus genome is quiescent, except for the transcription of the latency associated transcripts (LATs). Thus, it has been considered that LATs play an important role for latency and reactivation of the virus. It has been shown that LATs are required for efficient reactivation from latency in vivo, and regulate the site specificity for reactivation of the virus. Recent studies demonstrated that the quantities of latent virus are correlated with the frequency of reactivation of the virus. Moreover, it was suggested that the latency-related gene of bovine herpesvirus 1 could inhibit the apoptosis of the several cells including neuronal cells.

AB - Alpha herpesviridae (herpes simplex virus, HSV and varicella zoster virus, VZV) is a neurotropic phathogen of humans that establishes latent infection in the sensory ganglia, and periodically reactivates from latently infected neurons. Most of basic research for analyzing the mechanism of latency and reactivation of herpes viruses has been carried out in HSV. According to the results from the molecular analysis in the neurons latently infected with HSV, during latency, the virus genome is quiescent, except for the transcription of the latency associated transcripts (LATs). Thus, it has been considered that LATs play an important role for latency and reactivation of the virus. It has been shown that LATs are required for efficient reactivation from latency in vivo, and regulate the site specificity for reactivation of the virus. Recent studies demonstrated that the quantities of latent virus are correlated with the frequency of reactivation of the virus. Moreover, it was suggested that the latency-related gene of bovine herpesvirus 1 could inhibit the apoptosis of the several cells including neuronal cells.

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