The melanocortin agonist melanotan II increases insulin sensitivity in OLETF rats

Ryouichi Banno, Hiroshi Arima, Ikuko Sato, Masayuki Hayashi, Motomitsu Goto, Yoshihisa Sugimura, Takashi Murase, Yutaka Oiso

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Effects of peripheral administration of melanotan II (MTII), a melanocortin agonist, on insulin sensitivity and glucose tolerance were examined in Otsuka Long-Evans Tokushima Fatty (OLETF) rats. Subcutaneous administration of MTII with osmotic mini-pumps decreased food intake and body weight in OLETF rats. MTII group showed more sensitivity to insulin compared with that allowed to eat ad libitum or pair-fed group in insulin tolerance tests on day 9. MTII group also showed significantly lower glucose values than ad libitum group in glucose tolerance tests on days 11 and 23. Thus, MTII increased insulin sensitivity and improved glucose tolerance in OLETF rats.

Original languageEnglish
Pages (from-to)1279-1286
Number of pages8
JournalPeptides
Volume25
Issue number8
DOIs
Publication statusPublished - 01-08-2004

Fingerprint

Inbred OLETF Rats
Melanocortins
Insulin Resistance
Rats
Insulin
Glucose
Glucose Tolerance Test
Eating
Body Weight
melanotan-II
Pumps

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

Cite this

Banno, Ryouichi ; Arima, Hiroshi ; Sato, Ikuko ; Hayashi, Masayuki ; Goto, Motomitsu ; Sugimura, Yoshihisa ; Murase, Takashi ; Oiso, Yutaka. / The melanocortin agonist melanotan II increases insulin sensitivity in OLETF rats. In: Peptides. 2004 ; Vol. 25, No. 8. pp. 1279-1286.
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Banno, R, Arima, H, Sato, I, Hayashi, M, Goto, M, Sugimura, Y, Murase, T & Oiso, Y 2004, 'The melanocortin agonist melanotan II increases insulin sensitivity in OLETF rats', Peptides, vol. 25, no. 8, pp. 1279-1286. https://doi.org/10.1016/j.peptides.2004.05.007

The melanocortin agonist melanotan II increases insulin sensitivity in OLETF rats. / Banno, Ryouichi; Arima, Hiroshi; Sato, Ikuko; Hayashi, Masayuki; Goto, Motomitsu; Sugimura, Yoshihisa; Murase, Takashi; Oiso, Yutaka.

In: Peptides, Vol. 25, No. 8, 01.08.2004, p. 1279-1286.

Research output: Contribution to journalArticle

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T1 - The melanocortin agonist melanotan II increases insulin sensitivity in OLETF rats

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AU - Goto, Motomitsu

AU - Sugimura, Yoshihisa

AU - Murase, Takashi

AU - Oiso, Yutaka

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