The melanocortin agonist melanotan II increases insulin sensitivity in OLETF rats

Ryouichi Banno, Hiroshi Arima, Ikuko Sato, Masayuki Hayashi, Motomitsu Goto, Yoshihisa Sugimura, Takashi Murase, Yutaka Oiso

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


Effects of peripheral administration of melanotan II (MTII), a melanocortin agonist, on insulin sensitivity and glucose tolerance were examined in Otsuka Long-Evans Tokushima Fatty (OLETF) rats. Subcutaneous administration of MTII with osmotic mini-pumps decreased food intake and body weight in OLETF rats. MTII group showed more sensitivity to insulin compared with that allowed to eat ad libitum or pair-fed group in insulin tolerance tests on day 9. MTII group also showed significantly lower glucose values than ad libitum group in glucose tolerance tests on days 11 and 23. Thus, MTII increased insulin sensitivity and improved glucose tolerance in OLETF rats.

Original languageEnglish
Pages (from-to)1279-1286
Number of pages8
Issue number8
Publication statusPublished - 01-08-2004
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience


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