The melanocortin agonist melanotan II increases insulin sensitivity in OLETF rats

Ryouichi Banno; Hiroshi Arima; Ikuko Sato; Masayuki Hayashi; Motomitsu Goto; Yoshihisa Sugimura; Takashi Murase; Yutaka Oiso

doi:10.1016/j.peptides.2004.05.007

The melanocortin agonist melanotan II increases insulin sensitivity in OLETF rats

Ryouichi Banno, Hiroshi Arima, Ikuko Sato, Masayuki Hayashi, Motomitsu Goto, Yoshihisa Sugimura, Takashi Murase, Yutaka Oiso

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Effects of peripheral administration of melanotan II (MTII), a melanocortin agonist, on insulin sensitivity and glucose tolerance were examined in Otsuka Long-Evans Tokushima Fatty (OLETF) rats. Subcutaneous administration of MTII with osmotic mini-pumps decreased food intake and body weight in OLETF rats. MTII group showed more sensitivity to insulin compared with that allowed to eat ad libitum or pair-fed group in insulin tolerance tests on day 9. MTII group also showed significantly lower glucose values than ad libitum group in glucose tolerance tests on days 11 and 23. Thus, MTII increased insulin sensitivity and improved glucose tolerance in OLETF rats.

Original language	English
Pages (from-to)	1279-1286
Number of pages	8
Journal	Peptides
Volume	25
Issue number	8
DOIs	https://doi.org/10.1016/j.peptides.2004.05.007
Publication status	Published - 08-2004
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Physiology
Endocrinology
Cellular and Molecular Neuroscience

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10.1016/j.peptides.2004.05.007

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title = "The melanocortin agonist melanotan II increases insulin sensitivity in OLETF rats",

abstract = "Effects of peripheral administration of melanotan II (MTII), a melanocortin agonist, on insulin sensitivity and glucose tolerance were examined in Otsuka Long-Evans Tokushima Fatty (OLETF) rats. Subcutaneous administration of MTII with osmotic mini-pumps decreased food intake and body weight in OLETF rats. MTII group showed more sensitivity to insulin compared with that allowed to eat ad libitum or pair-fed group in insulin tolerance tests on day 9. MTII group also showed significantly lower glucose values than ad libitum group in glucose tolerance tests on days 11 and 23. Thus, MTII increased insulin sensitivity and improved glucose tolerance in OLETF rats.",

author = "Ryouichi Banno and Hiroshi Arima and Ikuko Sato and Masayuki Hayashi and Motomitsu Goto and Yoshihisa Sugimura and Takashi Murase and Yutaka Oiso",

year = "2004",

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doi = "10.1016/j.peptides.2004.05.007",

language = "English",

volume = "25",

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T1 - The melanocortin agonist melanotan II increases insulin sensitivity in OLETF rats

AU - Banno, Ryouichi

AU - Arima, Hiroshi

AU - Sato, Ikuko

AU - Hayashi, Masayuki

AU - Goto, Motomitsu

AU - Sugimura, Yoshihisa

AU - Murase, Takashi

AU - Oiso, Yutaka

PY - 2004/8

Y1 - 2004/8

N2 - Effects of peripheral administration of melanotan II (MTII), a melanocortin agonist, on insulin sensitivity and glucose tolerance were examined in Otsuka Long-Evans Tokushima Fatty (OLETF) rats. Subcutaneous administration of MTII with osmotic mini-pumps decreased food intake and body weight in OLETF rats. MTII group showed more sensitivity to insulin compared with that allowed to eat ad libitum or pair-fed group in insulin tolerance tests on day 9. MTII group also showed significantly lower glucose values than ad libitum group in glucose tolerance tests on days 11 and 23. Thus, MTII increased insulin sensitivity and improved glucose tolerance in OLETF rats.

AB - Effects of peripheral administration of melanotan II (MTII), a melanocortin agonist, on insulin sensitivity and glucose tolerance were examined in Otsuka Long-Evans Tokushima Fatty (OLETF) rats. Subcutaneous administration of MTII with osmotic mini-pumps decreased food intake and body weight in OLETF rats. MTII group showed more sensitivity to insulin compared with that allowed to eat ad libitum or pair-fed group in insulin tolerance tests on day 9. MTII group also showed significantly lower glucose values than ad libitum group in glucose tolerance tests on days 11 and 23. Thus, MTII increased insulin sensitivity and improved glucose tolerance in OLETF rats.

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JO - Peptides

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ER -

The melanocortin agonist melanotan II increases insulin sensitivity in OLETF rats

Abstract

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