The most primitive vertebrates with jaws possess highly polymorphic MHC class I genes comparable to those of humans

Kazuhiko Okamura, Mitsuru Ototake, Teruyuki Nakanishi, Yoshikazu Kurosawa, Keiichiro Hashimoto

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

We report the isolation and extensive analysis of highly polymorphic MHC class I genes from sharks (Triakis scyllia), which belong to the most primitive vertebrate group with jaws, the cartilaginous fish. Predicted complete peptide-binding domains showed retention of the critical amino acid residues that would interact with antigenic peptide termini and revealed extensive allelic polymorphisms comparable to those of classic human MHC class I molecules. Mosaic structures were apparent in these domains, suggesting recombinational mechanisms to create allelic diversity. The present study demonstrates the establishment of the basic strategy for antigen-presentation employed by MHC class I molecules and documents complete divergence of two polymorphic MHC classes at a phylogenetically primitive stage of vertebrate evolution.

Original languageEnglish
Pages (from-to)777-790
Number of pages14
JournalImmunity
Volume7
Issue number6
DOIs
Publication statusPublished - 01-01-1997

Fingerprint

MHC Class I Genes
Jaw
Vertebrates
Sharks
Antigen Presentation
Fishes
Amino Acids
Peptides
Protein Domains

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Cite this

Okamura, Kazuhiko ; Ototake, Mitsuru ; Nakanishi, Teruyuki ; Kurosawa, Yoshikazu ; Hashimoto, Keiichiro. / The most primitive vertebrates with jaws possess highly polymorphic MHC class I genes comparable to those of humans. In: Immunity. 1997 ; Vol. 7, No. 6. pp. 777-790.
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The most primitive vertebrates with jaws possess highly polymorphic MHC class I genes comparable to those of humans. / Okamura, Kazuhiko; Ototake, Mitsuru; Nakanishi, Teruyuki; Kurosawa, Yoshikazu; Hashimoto, Keiichiro.

In: Immunity, Vol. 7, No. 6, 01.01.1997, p. 777-790.

Research output: Contribution to journalArticle

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