Abstract
We report the isolation and extensive analysis of highly polymorphic MHC class I genes from sharks (Triakis scyllia), which belong to the most primitive vertebrate group with jaws, the cartilaginous fish. Predicted complete peptide-binding domains showed retention of the critical amino acid residues that would interact with antigenic peptide termini and revealed extensive allelic polymorphisms comparable to those of classic human MHC class I molecules. Mosaic structures were apparent in these domains, suggesting recombinational mechanisms to create allelic diversity. The present study demonstrates the establishment of the basic strategy for antigen-presentation employed by MHC class I molecules and documents complete divergence of two polymorphic MHC classes at a phylogenetically primitive stage of vertebrate evolution.
| Original language | English |
|---|---|
| Pages (from-to) | 777-790 |
| Number of pages | 14 |
| Journal | Immunity |
| Volume | 7 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 12-1997 |
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All Science Journal Classification (ASJC) codes
- Immunology and Allergy
- Immunology
- Infectious Diseases
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The most primitive vertebrates with jaws possess highly polymorphic MHC class I genes comparable to those of humans. / Okamura, Kazuhiko; Ototake, Mitsuru; Nakanishi, Teruyuki; Kurosawa, Yoshikazu; Hashimoto, Keiichiro.
In: Immunity, Vol. 7, No. 6, 12.1997, p. 777-790.Research output: Contribution to journal › Article
TY - JOUR
T1 - The most primitive vertebrates with jaws possess highly polymorphic MHC class I genes comparable to those of humans
AU - Okamura, Kazuhiko
AU - Ototake, Mitsuru
AU - Nakanishi, Teruyuki
AU - Kurosawa, Yoshikazu
AU - Hashimoto, Keiichiro
PY - 1997/12
Y1 - 1997/12
N2 - We report the isolation and extensive analysis of highly polymorphic MHC class I genes from sharks (Triakis scyllia), which belong to the most primitive vertebrate group with jaws, the cartilaginous fish. Predicted complete peptide-binding domains showed retention of the critical amino acid residues that would interact with antigenic peptide termini and revealed extensive allelic polymorphisms comparable to those of classic human MHC class I molecules. Mosaic structures were apparent in these domains, suggesting recombinational mechanisms to create allelic diversity. The present study demonstrates the establishment of the basic strategy for antigen-presentation employed by MHC class I molecules and documents complete divergence of two polymorphic MHC classes at a phylogenetically primitive stage of vertebrate evolution.
AB - We report the isolation and extensive analysis of highly polymorphic MHC class I genes from sharks (Triakis scyllia), which belong to the most primitive vertebrate group with jaws, the cartilaginous fish. Predicted complete peptide-binding domains showed retention of the critical amino acid residues that would interact with antigenic peptide termini and revealed extensive allelic polymorphisms comparable to those of classic human MHC class I molecules. Mosaic structures were apparent in these domains, suggesting recombinational mechanisms to create allelic diversity. The present study demonstrates the establishment of the basic strategy for antigen-presentation employed by MHC class I molecules and documents complete divergence of two polymorphic MHC classes at a phylogenetically primitive stage of vertebrate evolution.
UR - http://www.scopus.com/inward/record.url?scp=0031424262&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031424262&partnerID=8YFLogxK
U2 - 10.1016/S1074-7613(00)80396-9
DO - 10.1016/S1074-7613(00)80396-9
M3 - Article
C2 - 9430223
AN - SCOPUS:0031424262
VL - 7
SP - 777
EP - 790
JO - Immunity
JF - Immunity
SN - 1074-7613
IS - 6
ER -