The NAFLD Index: A Simple and Accurate Screening Tool for the Prediction of Non-Alcoholic Fatty Liver Disease

Naohiro Ichino, Keisuke Osakabe, Keiko Sugimoto, Koji Suzuki, Hiroya Yamada, Hiroji Takai, Hiroko Sugiyama, Jun Yukitake, Takashi Inoue, Koji Ohashi, Tadayoshi Hata, Nobuyuki Hamajima, Toru Nishikawa, Senju Hashimoto, Naoto Kawabe, Kentaro Yoshioka

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

OBJECTIVE: Non-alcoholic fatty liver disease (NAFLD) is a common debilitating condition in many industrialized countries that increases the risk of cardiovascular disease. The aim of this study was to derive a simple and accurate screening tool for the prediction of NAFLD in the Japanese population.

METHODS: A total of 945 participants, 279 men and 666 women living in Hokkaido, Japan, were enrolled among residents who attended a health check-up program from 2010 to 2014. Participants with an alcohol consumption > 20 g/day and/or a chronic liver disease, such as chronic hepatitis B, chronic hepatitis C or autoimmune hepatitis, were excluded from this study. Clinical and laboratory data were examined to identify predictive markers of NAFLD.

RESULTS: A new predictive index for NAFLD, the NAFLD index, was constructed for men and for women. The NAFLD index for men = -15.5693+0.3264 [BMI] +0.0134 [triglycerides (mg/dl)], and for women = -31.4686+0.3683 [BMI] +2.5699 [albumin (g/dl)] +4.6740[ALT/AST] -0.0379 [HDL cholesterol (mg/dl)]. The AUROC of the NAFLD index for men and for women was 0.87(95% CI 0.88-1.60) and 0.90 (95% CI 0.66-1.02), respectively. The cut-off point of -5.28 for men predicted NAFLD with an accuracy of 82.8%. For women, the cut-off point of -7.65 predicted NAFLD with an accuracy of 87.7%.

CONCLUSION: A new index for the non-invasive prediction of NAFLD, the NAFLD index, was constructed using available clinical and laboratory data. This index is a simple screening tool to predict the presence of NAFLD.

Original languageEnglish
Pages (from-to)32-43
Number of pages12
JournalRinsho byori. The Japanese journal of clinical pathology
Volume63
Issue number1
Publication statusPublished - 01-01-2015

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Non-alcoholic Fatty Liver Disease
Autoimmune Hepatitis
Chronic Hepatitis B
Chronic Hepatitis C
Developed Countries
Alcohol Drinking
HDL Cholesterol
Liver Diseases
Albumins
Japan
Triglycerides
Chronic Disease
Cardiovascular Diseases
Health
Population

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Ichino, Naohiro ; Osakabe, Keisuke ; Sugimoto, Keiko ; Suzuki, Koji ; Yamada, Hiroya ; Takai, Hiroji ; Sugiyama, Hiroko ; Yukitake, Jun ; Inoue, Takashi ; Ohashi, Koji ; Hata, Tadayoshi ; Hamajima, Nobuyuki ; Nishikawa, Toru ; Hashimoto, Senju ; Kawabe, Naoto ; Yoshioka, Kentaro. / The NAFLD Index : A Simple and Accurate Screening Tool for the Prediction of Non-Alcoholic Fatty Liver Disease. In: Rinsho byori. The Japanese journal of clinical pathology. 2015 ; Vol. 63, No. 1. pp. 32-43.
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title = "The NAFLD Index: A Simple and Accurate Screening Tool for the Prediction of Non-Alcoholic Fatty Liver Disease",
abstract = "OBJECTIVE: Non-alcoholic fatty liver disease (NAFLD) is a common debilitating condition in many industrialized countries that increases the risk of cardiovascular disease. The aim of this study was to derive a simple and accurate screening tool for the prediction of NAFLD in the Japanese population.METHODS: A total of 945 participants, 279 men and 666 women living in Hokkaido, Japan, were enrolled among residents who attended a health check-up program from 2010 to 2014. Participants with an alcohol consumption > 20 g/day and/or a chronic liver disease, such as chronic hepatitis B, chronic hepatitis C or autoimmune hepatitis, were excluded from this study. Clinical and laboratory data were examined to identify predictive markers of NAFLD.RESULTS: A new predictive index for NAFLD, the NAFLD index, was constructed for men and for women. The NAFLD index for men = -15.5693+0.3264 [BMI] +0.0134 [triglycerides (mg/dl)], and for women = -31.4686+0.3683 [BMI] +2.5699 [albumin (g/dl)] +4.6740[ALT/AST] -0.0379 [HDL cholesterol (mg/dl)]. The AUROC of the NAFLD index for men and for women was 0.87(95{\%} CI 0.88-1.60) and 0.90 (95{\%} CI 0.66-1.02), respectively. The cut-off point of -5.28 for men predicted NAFLD with an accuracy of 82.8{\%}. For women, the cut-off point of -7.65 predicted NAFLD with an accuracy of 87.7{\%}.CONCLUSION: A new index for the non-invasive prediction of NAFLD, the NAFLD index, was constructed using available clinical and laboratory data. This index is a simple screening tool to predict the presence of NAFLD.",
author = "Naohiro Ichino and Keisuke Osakabe and Keiko Sugimoto and Koji Suzuki and Hiroya Yamada and Hiroji Takai and Hiroko Sugiyama and Jun Yukitake and Takashi Inoue and Koji Ohashi and Tadayoshi Hata and Nobuyuki Hamajima and Toru Nishikawa and Senju Hashimoto and Naoto Kawabe and Kentaro Yoshioka",
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Ichino, N, Osakabe, K, Sugimoto, K, Suzuki, K, Yamada, H, Takai, H, Sugiyama, H, Yukitake, J, Inoue, T, Ohashi, K, Hata, T, Hamajima, N, Nishikawa, T, Hashimoto, S, Kawabe, N & Yoshioka, K 2015, 'The NAFLD Index: A Simple and Accurate Screening Tool for the Prediction of Non-Alcoholic Fatty Liver Disease', Rinsho byori. The Japanese journal of clinical pathology, vol. 63, no. 1, pp. 32-43.

The NAFLD Index : A Simple and Accurate Screening Tool for the Prediction of Non-Alcoholic Fatty Liver Disease. / Ichino, Naohiro; Osakabe, Keisuke; Sugimoto, Keiko; Suzuki, Koji; Yamada, Hiroya; Takai, Hiroji; Sugiyama, Hiroko; Yukitake, Jun; Inoue, Takashi; Ohashi, Koji; Hata, Tadayoshi; Hamajima, Nobuyuki; Nishikawa, Toru; Hashimoto, Senju; Kawabe, Naoto; Yoshioka, Kentaro.

In: Rinsho byori. The Japanese journal of clinical pathology, Vol. 63, No. 1, 01.01.2015, p. 32-43.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The NAFLD Index

T2 - A Simple and Accurate Screening Tool for the Prediction of Non-Alcoholic Fatty Liver Disease

AU - Ichino, Naohiro

AU - Osakabe, Keisuke

AU - Sugimoto, Keiko

AU - Suzuki, Koji

AU - Yamada, Hiroya

AU - Takai, Hiroji

AU - Sugiyama, Hiroko

AU - Yukitake, Jun

AU - Inoue, Takashi

AU - Ohashi, Koji

AU - Hata, Tadayoshi

AU - Hamajima, Nobuyuki

AU - Nishikawa, Toru

AU - Hashimoto, Senju

AU - Kawabe, Naoto

AU - Yoshioka, Kentaro

PY - 2015/1/1

Y1 - 2015/1/1

N2 - OBJECTIVE: Non-alcoholic fatty liver disease (NAFLD) is a common debilitating condition in many industrialized countries that increases the risk of cardiovascular disease. The aim of this study was to derive a simple and accurate screening tool for the prediction of NAFLD in the Japanese population.METHODS: A total of 945 participants, 279 men and 666 women living in Hokkaido, Japan, were enrolled among residents who attended a health check-up program from 2010 to 2014. Participants with an alcohol consumption > 20 g/day and/or a chronic liver disease, such as chronic hepatitis B, chronic hepatitis C or autoimmune hepatitis, were excluded from this study. Clinical and laboratory data were examined to identify predictive markers of NAFLD.RESULTS: A new predictive index for NAFLD, the NAFLD index, was constructed for men and for women. The NAFLD index for men = -15.5693+0.3264 [BMI] +0.0134 [triglycerides (mg/dl)], and for women = -31.4686+0.3683 [BMI] +2.5699 [albumin (g/dl)] +4.6740[ALT/AST] -0.0379 [HDL cholesterol (mg/dl)]. The AUROC of the NAFLD index for men and for women was 0.87(95% CI 0.88-1.60) and 0.90 (95% CI 0.66-1.02), respectively. The cut-off point of -5.28 for men predicted NAFLD with an accuracy of 82.8%. For women, the cut-off point of -7.65 predicted NAFLD with an accuracy of 87.7%.CONCLUSION: A new index for the non-invasive prediction of NAFLD, the NAFLD index, was constructed using available clinical and laboratory data. This index is a simple screening tool to predict the presence of NAFLD.

AB - OBJECTIVE: Non-alcoholic fatty liver disease (NAFLD) is a common debilitating condition in many industrialized countries that increases the risk of cardiovascular disease. The aim of this study was to derive a simple and accurate screening tool for the prediction of NAFLD in the Japanese population.METHODS: A total of 945 participants, 279 men and 666 women living in Hokkaido, Japan, were enrolled among residents who attended a health check-up program from 2010 to 2014. Participants with an alcohol consumption > 20 g/day and/or a chronic liver disease, such as chronic hepatitis B, chronic hepatitis C or autoimmune hepatitis, were excluded from this study. Clinical and laboratory data were examined to identify predictive markers of NAFLD.RESULTS: A new predictive index for NAFLD, the NAFLD index, was constructed for men and for women. The NAFLD index for men = -15.5693+0.3264 [BMI] +0.0134 [triglycerides (mg/dl)], and for women = -31.4686+0.3683 [BMI] +2.5699 [albumin (g/dl)] +4.6740[ALT/AST] -0.0379 [HDL cholesterol (mg/dl)]. The AUROC of the NAFLD index for men and for women was 0.87(95% CI 0.88-1.60) and 0.90 (95% CI 0.66-1.02), respectively. The cut-off point of -5.28 for men predicted NAFLD with an accuracy of 82.8%. For women, the cut-off point of -7.65 predicted NAFLD with an accuracy of 87.7%.CONCLUSION: A new index for the non-invasive prediction of NAFLD, the NAFLD index, was constructed using available clinical and laboratory data. This index is a simple screening tool to predict the presence of NAFLD.

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