The nationwide study of bacterial pathogens associated with urinary tract infections conducted by the Japanese Society of Chemotherapy

Kiyohito Ishikawa, Tetsuro Matsumoto, Mitsuru Yasuda, Shinya Uehara, Tetsuro Muratani, Morimasa Yagisawa, Junko Sato, Yoshihito Niki, Kyoichi Totsuka, Keisuke Sunakawa, Hideaki Hanaki, Rikizo Hattori, Michinori Terada, Tsuneo Kozuki, Akinori Maruo, Kohei Morita, Kazuhiko Ogasawara, Yoshisaburo Takahashi, Kenji Matsuda, Takaoki HiroseNoriomi Miyao, Tasuku Hayashi, Koh Takeyama, Hiroshi Kiyota, Masayuki Tomita, Hisashi Yusu, Haruhisa Koide, Shoji Kimura, Masanori Yanaoka, Hajime Sato, Toru Ito, Takashi Deguchi, Yoshinori Fujimoto, Hisao Komeda, Yuko Asano, Yoshito Takahashi, Satoshi Ishihara, Soichi Arakawa, Yuzo Nakano, Kazushi Tanaka, Masato Fujisawa, Takashi Matsui, Akira Fujii, Shingo Yamamoto, Michio Nojima, Yoshihide Higuchi, Yasuo Ueda, Sojun Kanamaru, Koichi Monden, Tomoyasu Tsushima, Yuko Seno, Masaya Tsugawa, Tadasu Takenaka, Ryoichi Hamasuna, Naohiro Fujimoto, Takehiko Sho, Koichi Takahashi, Hisato Inatomi, Naoya Takahashi, Yoshihiko Ikei, Hiroshi Hayami, Takashi Yamane, Masayuki Nakagawa, Satoru Kariya, Takashi Arima

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Abstract

This study was conducted by the Japanese Society of Chemotherapy and is the first nationwide study on bacterial pathogens isolated from patients with urinary tract infections at 28 hospitals throughout Japan between January 2008 and June 2008. A total of 688 bacterial strains were isolated from adult patients with urinary tract infections. The strains investigated in this study are as follows: Enterococcus faecalis (n = 140), Escherichia coli (n = 255), Klebsiella pneumoniae (n = 93), Proteus mirabilis (n = 42), Serratia marcescens (n = 44), and Pseudomonas aeruginosa (n = 114). The minimum inhibitory concentrations of 39 antibacterial agents used for these strains were determined according to the Clinical and Laboratory Standards Institute (CLSI) manual. All Enterococcus faecalis strains were susceptible to ampicillin and vancomycin. Although a majority of the E. faecalis strains were susceptible to linezolid, 11 strains (7.8%) were found to be intermediately resistant. The proportions of fluoroquinolone-resistant Enterococcus faecalis, Escherichia coli, Proteus mirabilis, and S. marcescens strains were 35.7%, 29.3%, 18.3%, and 15.2%, respectively. The proportions of E. coli, P. mirabilis, K. pneumoniae, and S. marcescens strains producing extended-spectrum β-lactamase were 5.1%, 11.9%, 0%, and 0%, respectively. The proportions of Pseudomonas aeruginosa strains resistant to carbapenems, aminoglycosides, and fluoroquinolones were 9.2%, 4.4%, and 34.8%, respectively, and among them, 2 strains (1.8%) were found to be multidrug resistant. These data present important information for the proper treatment of urinary tract infections and will serve as a useful reference for periodic surveillance studies in the future.

Original languageEnglish
Pages (from-to)126-138
Number of pages13
JournalJournal of Infection and Chemotherapy
Volume17
Issue number1
DOIs
Publication statusPublished - 02-2011

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

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    Ishikawa, K., Matsumoto, T., Yasuda, M., Uehara, S., Muratani, T., Yagisawa, M., Sato, J., Niki, Y., Totsuka, K., Sunakawa, K., Hanaki, H., Hattori, R., Terada, M., Kozuki, T., Maruo, A., Morita, K., Ogasawara, K., Takahashi, Y., Matsuda, K., ... Arima, T. (2011). The nationwide study of bacterial pathogens associated with urinary tract infections conducted by the Japanese Society of Chemotherapy. Journal of Infection and Chemotherapy, 17(1), 126-138. https://doi.org/10.1007/s10156-010-0174-1