@article{ddba8719dd7c452baaef5a134ea82fcd,
title = "The neural network basis of altered decision-making in patients with amyotrophic lateral sclerosis",
abstract = "Objective: Amyotrophic lateral sclerosis (ALS) is a multisystem disorder associated with motor impairment and behavioral/cognitive involvement. We examined decision-making features and changes in the neural hub network in patients with ALS using a probabilistic reversal learning task and resting-state network analysis, respectively. Methods: Ninety ALS patients and 127 cognitively normal participants performed this task. Data from 62 ALS patients and 63 control participants were fitted to a Q-learning model. Results: ALS patients had anomalous decision-making features with little shift in choice until they thought the value of the two alternatives had become equal. The quantified parameters (Pαβ) calculated by logistic regression analysis with learning rate and inverse temperature well represented the unique choice pattern of ALS patients. Resting-state network analysis demonstrated a strong correlation between Pαβ and decreased degree centrality in the anterior cingulate gyrus and frontal pole. Interpretation: Altered decision-making in ALS patients may be related to the decreased hub function of medial prefrontal areas.",
author = "Kazunori Imai and Michihito Masuda and Hirohisa Watanabe and Aya Ogura and Reiko Ohdake and Yasuhiro Tanaka and Toshiyasu Kato and Kazuya Kawabata and Yuichi Riku and Kazuhiro Hara and Ryoichi Nakamura and Naoki Atsuta and Epifanio Bagarinao and Kentaro Katahira and Hideki Ohira and Masahisa Katsuno and Gen Sobue",
note = "Funding Information: This study was partially supported by a Grant‐in‐Aid from the Research Committee of Central Nervous System Degenerative Diseases by the Ministry of Health, Labour, and Welfare, Integrated Research on Neuropsychiatric Disorders project carried out Strategic Research Program for Brain Sciences (SRPBS), a Grant‐in‐Aid for Scientific Research on Innovative Areas (Brain Protein Aging and Dementia Control 26117002) from the Ministry of Education, Culture, Sports, Science, and Technology of Japan, as well as Integrated Research on neuropsychiatric disorders carried out under the SRPBS, Scientific Research on Innovative Areas (Comprehensive Brain Science Network), and Integrated Research on Depression, Dementia, and Development Disorders by SRPBS from Japan Agency for Medical Research and development. Publisher Copyright: {\textcopyright} 2020 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.",
year = "2020",
month = nov,
doi = "10.1002/acn3.51185",
language = "English",
volume = "7",
pages = "2115--2126",
journal = "Annals of Clinical and Translational Neurology",
issn = "2328-9503",
publisher = "John Wiley and Sons Ltd",
number = "11",
}