The outer membrane fraction of Flavobacterium psychrophilum induces protective immunity in rainbow trout and ayu

M. Habibur Rahman; Akashi Kuroda; Johannes M. Dijkstra; Ikunari Kiryu; Teruyuki Nakanishi; Mitsuru Ototake

doi:10.1006/fsim.2001.0362

The outer membrane fraction of Flavobacterium psychrophilum induces protective immunity in rainbow trout and ayu

M. Habibur Rahman, Akashi Kuroda, Johannes M. Dijkstra, Ikunari Kiryu, Teruyuki Nakanishi, Mitsuru Ototake

Research output: Contribution to journal › Article › peer-review

64 Citations (Scopus)

Abstract

Flavobacterium psychrophilum is the causative agent of coldwater disease, which is responsible for serious losses in fish aquaculture in several parts of the world. No commercial vaccines are currently available for the prevention of coldwater disease. The present study sought to assess the efficacy of a F. psychrophilum vaccine based on the antigenic outer membrane fraction (OMF). This fraction induced significantly higher protection against coldwater disease in both rainbow trout (Oncorhynchus mykiss) and ayu (Plecoglossus altivelis) compared to inactivated whole cell F. psychrophilum bacterin. Coincident with higher protection, sera of fish immunised with the OMF vaccine had higher agglutination titres than those of fish immunised with inactivated whole cell F. psychrophilum.

Original language	English
Pages (from-to)	169-179
Number of pages	11
Journal	Fish and Shellfish Immunology
Volume	12
Issue number	2
DOIs	https://doi.org/10.1006/fsim.2001.0362
Publication status	Published - 01-01-2002
Externally published	Yes

All Science Journal Classification (ASJC) codes

Environmental Chemistry
Aquatic Science

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10.1006/fsim.2001.0362

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title = "The outer membrane fraction of Flavobacterium psychrophilum induces protective immunity in rainbow trout and ayu",

abstract = "Flavobacterium psychrophilum is the causative agent of coldwater disease, which is responsible for serious losses in fish aquaculture in several parts of the world. No commercial vaccines are currently available for the prevention of coldwater disease. The present study sought to assess the efficacy of a F. psychrophilum vaccine based on the antigenic outer membrane fraction (OMF). This fraction induced significantly higher protection against coldwater disease in both rainbow trout (Oncorhynchus mykiss) and ayu (Plecoglossus altivelis) compared to inactivated whole cell F. psychrophilum bacterin. Coincident with higher protection, sera of fish immunised with the OMF vaccine had higher agglutination titres than those of fish immunised with inactivated whole cell F. psychrophilum.",

author = "Rahman, {M. Habibur} and Akashi Kuroda and Dijkstra, {Johannes M.} and Ikunari Kiryu and Teruyuki Nakanishi and Mitsuru Ototake",

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The outer membrane fraction of Flavobacterium psychrophilum induces protective immunity in rainbow trout and ayu. / Rahman, M. Habibur; Kuroda, Akashi; Dijkstra, Johannes M.; Kiryu, Ikunari; Nakanishi, Teruyuki; Ototake, Mitsuru.

In: Fish and Shellfish Immunology, Vol. 12, No. 2, 01.01.2002, p. 169-179.

Research output: Contribution to journal › Article › peer-review

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AU - Rahman, M. Habibur

AU - Kuroda, Akashi

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AU - Nakanishi, Teruyuki

AU - Ototake, Mitsuru

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AB - Flavobacterium psychrophilum is the causative agent of coldwater disease, which is responsible for serious losses in fish aquaculture in several parts of the world. No commercial vaccines are currently available for the prevention of coldwater disease. The present study sought to assess the efficacy of a F. psychrophilum vaccine based on the antigenic outer membrane fraction (OMF). This fraction induced significantly higher protection against coldwater disease in both rainbow trout (Oncorhynchus mykiss) and ayu (Plecoglossus altivelis) compared to inactivated whole cell F. psychrophilum bacterin. Coincident with higher protection, sera of fish immunised with the OMF vaccine had higher agglutination titres than those of fish immunised with inactivated whole cell F. psychrophilum.

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