TY - JOUR
T1 - The outer membrane fraction of Flavobacterium psychrophilum induces protective immunity in rainbow trout and ayu
AU - Rahman, M. Habibur
AU - Kuroda, Akashi
AU - Dijkstra, Johannes M.
AU - Kiryu, Ikunari
AU - Nakanishi, Teruyuki
AU - Ototake, Mitsuru
N1 - Funding Information:
The authors are thankful to Mr Yoshisuke Iida, Freshwater Fish Branch, Hiroshima Prefectural Fisheries Experiment Station, Shobara, Hiroshima 727, Japan, for providing the bacterial isolate. The authors are also grateful to the Nagano Prefectural Fisheries Experimental Station, Nagano, Japan for providing eyed eggs of rainbow trout. The first author is grateful to the Japan Ministry Education, Culture, Sports, Science and Technology for granting him a STA Post-doctoral Fellowship and thankful to the Department of Zoology, Rajshahi University, Bangladesh for granting him leave during this research. The authors gratefully thank Dr James D. Moore, Bodega Marine Laboratory, Bodega Bay, California, U.S.A., for editorial assistance with this manuscript.
PY - 2002
Y1 - 2002
N2 - Flavobacterium psychrophilum is the causative agent of coldwater disease, which is responsible for serious losses in fish aquaculture in several parts of the world. No commercial vaccines are currently available for the prevention of coldwater disease. The present study sought to assess the efficacy of a F. psychrophilum vaccine based on the antigenic outer membrane fraction (OMF). This fraction induced significantly higher protection against coldwater disease in both rainbow trout (Oncorhynchus mykiss) and ayu (Plecoglossus altivelis) compared to inactivated whole cell F. psychrophilum bacterin. Coincident with higher protection, sera of fish immunised with the OMF vaccine had higher agglutination titres than those of fish immunised with inactivated whole cell F. psychrophilum.
AB - Flavobacterium psychrophilum is the causative agent of coldwater disease, which is responsible for serious losses in fish aquaculture in several parts of the world. No commercial vaccines are currently available for the prevention of coldwater disease. The present study sought to assess the efficacy of a F. psychrophilum vaccine based on the antigenic outer membrane fraction (OMF). This fraction induced significantly higher protection against coldwater disease in both rainbow trout (Oncorhynchus mykiss) and ayu (Plecoglossus altivelis) compared to inactivated whole cell F. psychrophilum bacterin. Coincident with higher protection, sera of fish immunised with the OMF vaccine had higher agglutination titres than those of fish immunised with inactivated whole cell F. psychrophilum.
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U2 - 10.1006/fsim.2001.0362
DO - 10.1006/fsim.2001.0362
M3 - Article
C2 - 11911677
AN - SCOPUS:0036166182
SN - 1050-4648
VL - 12
SP - 169
EP - 179
JO - Fish and Shellfish Immunology
JF - Fish and Shellfish Immunology
IS - 2
ER -
