The outer membrane fraction of Flavobacterium psychrophilum induces protective immunity in rainbow trout and ayu

M. Habibur Rahman, Akashi Kuroda, Johannes M. Dijkstra, Ikunari Kiryu, Teruyuki Nakanishi, Mitsuru Ototake

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Flavobacterium psychrophilum is the causative agent of coldwater disease, which is responsible for serious losses in fish aquaculture in several parts of the world. No commercial vaccines are currently available for the prevention of coldwater disease. The present study sought to assess the efficacy of a F. psychrophilum vaccine based on the antigenic outer membrane fraction (OMF). This fraction induced significantly higher protection against coldwater disease in both rainbow trout (Oncorhynchus mykiss) and ayu (Plecoglossus altivelis) compared to inactivated whole cell F. psychrophilum bacterin. Coincident with higher protection, sera of fish immunised with the OMF vaccine had higher agglutination titres than those of fish immunised with inactivated whole cell F. psychrophilum.

Original languageEnglish
Pages (from-to)169-179
Number of pages11
JournalFish and Shellfish Immunology
Volume12
Issue number2
DOIs
Publication statusPublished - 01-01-2002
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Environmental Chemistry
  • Aquatic Science

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