The p15(gag) and p12(gag) regions are both necessary for the pathogenicity of the murine AIDS virus

Y. Kubo, K. Kakimi, K. Higo, L. Wang, H. Kobayashi, K. Kuribayashi, T. Masuda, T. Hirama, A. Ishimoto

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

The defective murine AIDS (MAIDS) virus has unique sequences in its p15(gag) and p12(gag) regions. To clarify whether these sequences are responsible for the development of MAIDS, we constructed recombinant viruses by replacing various regions of the gag gene of the nonpathogenic replication-competent LP-BM5 ecotropic virus with those of the MAIDS virus. Recombinants containing both unique sequences of the MAIDS virus were replication defective and induced MAIDS. However, a recombinant containing either the p15(gag) or p12(gag) region of the MAIDS virus was also replication defective but nonpathogenic in mice. A recombinant virus containing only the p30(gag) region of the MAIDS virus was replication competent and nonpathogenic. These results indicate that the p15(gag) and p12(gag) regions of the MAIDS virus do not function like those of replication-competent viruses and that both of the unique sequences in the p15(gag) and p12(gag) regions are required to develop MAIDS.

Original languageEnglish
Pages (from-to)5532-5537
Number of pages6
JournalJournal of Virology
Volume68
Issue number9
DOIs
Publication statusPublished - 1994
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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