The polymorphism of YWHAE, a gene encoding 14-3-3epsilon, and orbitofrontal sulcogyral pattern in patients with schizophrenia and healthy subjects

Tsutomu Takahashi, Yumiko Nakamura, Yukako Nakamura, Branko Aleksic, Yoichiro Takayanagi, Atsushi Furuichi, Mikio Kido, Mihoko Nakamura, Daiki Sasabayashi, Masashi Ikeda, Kyo Noguchi, Kozo Kaibuchi, Nakao Iwata, Norio Ozaki, Michio Suzuki

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

An altered sulcogyral pattern in the orbitofrontal cortex (OFC) has been implicated in schizophrenia as a possible marker of abnormal neurodevelopment, while its genetic mechanism remains unknown. This magnetic resonance imaging study investigated the relationship between the polymorphism of YWHAE (rs28365859), a gene encoding 14-3-3epsilon that is a Disrupted-in-Schizophrenia 1 (DISC1)-interacting molecule associated with neuronal development, and the OFC subtypes of the 'H-shaped' sulcus (Types I, II, and III) in a Japanese sample of 72 schizophrenia patients and 86 healthy controls. The schizophrenia patients had significantly increased Type III (p=0.004) and decreased Type I (p=0.013) expression on the right hemisphere compared to the controls. The subjects carrying the protective C allele showed a decrease in Type III (p=0.005) and an increase in Type I (p=0.017) compared to the G allele homozygotes, especially for the healthy subjects in the left hemisphere. These results suggest a possible role for the YWHAE genotype in the early development of the OFC sulcogyral pattern, but its effect alone is not likely to explain the altered sulcogyral pattern in schizophrenia.

Original languageEnglish
Pages (from-to)166-171
Number of pages6
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume51
DOIs
Publication statusPublished - 03-06-2014

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Schizophrenia
Healthy Volunteers
Prefrontal Cortex
Genes
Alleles
Homozygote
Genotype
Magnetic Resonance Imaging

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Biological Psychiatry

Cite this

Takahashi, Tsutomu ; Nakamura, Yumiko ; Nakamura, Yukako ; Aleksic, Branko ; Takayanagi, Yoichiro ; Furuichi, Atsushi ; Kido, Mikio ; Nakamura, Mihoko ; Sasabayashi, Daiki ; Ikeda, Masashi ; Noguchi, Kyo ; Kaibuchi, Kozo ; Iwata, Nakao ; Ozaki, Norio ; Suzuki, Michio. / The polymorphism of YWHAE, a gene encoding 14-3-3epsilon, and orbitofrontal sulcogyral pattern in patients with schizophrenia and healthy subjects. In: Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2014 ; Vol. 51. pp. 166-171.
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abstract = "An altered sulcogyral pattern in the orbitofrontal cortex (OFC) has been implicated in schizophrenia as a possible marker of abnormal neurodevelopment, while its genetic mechanism remains unknown. This magnetic resonance imaging study investigated the relationship between the polymorphism of YWHAE (rs28365859), a gene encoding 14-3-3epsilon that is a Disrupted-in-Schizophrenia 1 (DISC1)-interacting molecule associated with neuronal development, and the OFC subtypes of the 'H-shaped' sulcus (Types I, II, and III) in a Japanese sample of 72 schizophrenia patients and 86 healthy controls. The schizophrenia patients had significantly increased Type III (p=0.004) and decreased Type I (p=0.013) expression on the right hemisphere compared to the controls. The subjects carrying the protective C allele showed a decrease in Type III (p=0.005) and an increase in Type I (p=0.017) compared to the G allele homozygotes, especially for the healthy subjects in the left hemisphere. These results suggest a possible role for the YWHAE genotype in the early development of the OFC sulcogyral pattern, but its effect alone is not likely to explain the altered sulcogyral pattern in schizophrenia.",
author = "Tsutomu Takahashi and Yumiko Nakamura and Yukako Nakamura and Branko Aleksic and Yoichiro Takayanagi and Atsushi Furuichi and Mikio Kido and Mihoko Nakamura and Daiki Sasabayashi and Masashi Ikeda and Kyo Noguchi and Kozo Kaibuchi and Nakao Iwata and Norio Ozaki and Michio Suzuki",
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Takahashi, T, Nakamura, Y, Nakamura, Y, Aleksic, B, Takayanagi, Y, Furuichi, A, Kido, M, Nakamura, M, Sasabayashi, D, Ikeda, M, Noguchi, K, Kaibuchi, K, Iwata, N, Ozaki, N & Suzuki, M 2014, 'The polymorphism of YWHAE, a gene encoding 14-3-3epsilon, and orbitofrontal sulcogyral pattern in patients with schizophrenia and healthy subjects', Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 51, pp. 166-171. https://doi.org/10.1016/j.pnpbp.2014.02.005

The polymorphism of YWHAE, a gene encoding 14-3-3epsilon, and orbitofrontal sulcogyral pattern in patients with schizophrenia and healthy subjects. / Takahashi, Tsutomu; Nakamura, Yumiko; Nakamura, Yukako; Aleksic, Branko; Takayanagi, Yoichiro; Furuichi, Atsushi; Kido, Mikio; Nakamura, Mihoko; Sasabayashi, Daiki; Ikeda, Masashi; Noguchi, Kyo; Kaibuchi, Kozo; Iwata, Nakao; Ozaki, Norio; Suzuki, Michio.

In: Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 51, 03.06.2014, p. 166-171.

Research output: Contribution to journalArticle

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T1 - The polymorphism of YWHAE, a gene encoding 14-3-3epsilon, and orbitofrontal sulcogyral pattern in patients with schizophrenia and healthy subjects

AU - Takahashi, Tsutomu

AU - Nakamura, Yumiko

AU - Nakamura, Yukako

AU - Aleksic, Branko

AU - Takayanagi, Yoichiro

AU - Furuichi, Atsushi

AU - Kido, Mikio

AU - Nakamura, Mihoko

AU - Sasabayashi, Daiki

AU - Ikeda, Masashi

AU - Noguchi, Kyo

AU - Kaibuchi, Kozo

AU - Iwata, Nakao

AU - Ozaki, Norio

AU - Suzuki, Michio

PY - 2014/6/3

Y1 - 2014/6/3

N2 - An altered sulcogyral pattern in the orbitofrontal cortex (OFC) has been implicated in schizophrenia as a possible marker of abnormal neurodevelopment, while its genetic mechanism remains unknown. This magnetic resonance imaging study investigated the relationship between the polymorphism of YWHAE (rs28365859), a gene encoding 14-3-3epsilon that is a Disrupted-in-Schizophrenia 1 (DISC1)-interacting molecule associated with neuronal development, and the OFC subtypes of the 'H-shaped' sulcus (Types I, II, and III) in a Japanese sample of 72 schizophrenia patients and 86 healthy controls. The schizophrenia patients had significantly increased Type III (p=0.004) and decreased Type I (p=0.013) expression on the right hemisphere compared to the controls. The subjects carrying the protective C allele showed a decrease in Type III (p=0.005) and an increase in Type I (p=0.017) compared to the G allele homozygotes, especially for the healthy subjects in the left hemisphere. These results suggest a possible role for the YWHAE genotype in the early development of the OFC sulcogyral pattern, but its effect alone is not likely to explain the altered sulcogyral pattern in schizophrenia.

AB - An altered sulcogyral pattern in the orbitofrontal cortex (OFC) has been implicated in schizophrenia as a possible marker of abnormal neurodevelopment, while its genetic mechanism remains unknown. This magnetic resonance imaging study investigated the relationship between the polymorphism of YWHAE (rs28365859), a gene encoding 14-3-3epsilon that is a Disrupted-in-Schizophrenia 1 (DISC1)-interacting molecule associated with neuronal development, and the OFC subtypes of the 'H-shaped' sulcus (Types I, II, and III) in a Japanese sample of 72 schizophrenia patients and 86 healthy controls. The schizophrenia patients had significantly increased Type III (p=0.004) and decreased Type I (p=0.013) expression on the right hemisphere compared to the controls. The subjects carrying the protective C allele showed a decrease in Type III (p=0.005) and an increase in Type I (p=0.017) compared to the G allele homozygotes, especially for the healthy subjects in the left hemisphere. These results suggest a possible role for the YWHAE genotype in the early development of the OFC sulcogyral pattern, but its effect alone is not likely to explain the altered sulcogyral pattern in schizophrenia.

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