TY - JOUR
T1 - The polymorphism of YWHAE, a gene encoding 14-3-3epsilon, and orbitofrontal sulcogyral pattern in patients with schizophrenia and healthy subjects
AU - Takahashi, Tsutomu
AU - Nakamura, Yumiko
AU - Nakamura, Yukako
AU - Aleksic, Branko
AU - Takayanagi, Yoichiro
AU - Furuichi, Atsushi
AU - Kido, Mikio
AU - Nakamura, Mihoko
AU - Sasabayashi, Daiki
AU - Ikeda, Masashi
AU - Noguchi, Kyo
AU - Kaibuchi, Kozo
AU - Iwata, Nakao
AU - Ozaki, Norio
AU - Suzuki, Michio
N1 - Funding Information:
This research was supported in part by Grants-in-Aid for Scientific Research (C) (Nos. 22591275 , 24591699 ) and Grant-in-Aid for Scientific Research (B) (No. 24390281 ) from the Japanese Society for the Promotion of Science, Health and Labour Sciences Research Grants (Comprehensive Research on Disability, Health and Welfare, H23-Seishin-Ippan-002 and H23-Seishin-Ippan-009) , a research grant from the JSPS Asian Core Program , and a grant from Research Group for Schizophrenia, Japan . It was also supported by a Grant-in-Aid for “Integrated research on neuropsychiatric disorders” carried out under the Strategic Research Program for Brain Sciences by the Ministry of Education, Culture, Sports, Science and Technology of Japan and Grant-in-Aid for Scientific Research on Innovative Areas, “Glial assembly: a new regulatory machinery of brain function and disorders”. We would like to thank Ms. Hiroko Itoh, who assisted in genomic DNA extraction for all the participants in this study.
PY - 2014/6/3
Y1 - 2014/6/3
N2 - An altered sulcogyral pattern in the orbitofrontal cortex (OFC) has been implicated in schizophrenia as a possible marker of abnormal neurodevelopment, while its genetic mechanism remains unknown. This magnetic resonance imaging study investigated the relationship between the polymorphism of YWHAE (rs28365859), a gene encoding 14-3-3epsilon that is a Disrupted-in-Schizophrenia 1 (DISC1)-interacting molecule associated with neuronal development, and the OFC subtypes of the 'H-shaped' sulcus (Types I, II, and III) in a Japanese sample of 72 schizophrenia patients and 86 healthy controls. The schizophrenia patients had significantly increased Type III (p=0.004) and decreased Type I (p=0.013) expression on the right hemisphere compared to the controls. The subjects carrying the protective C allele showed a decrease in Type III (p=0.005) and an increase in Type I (p=0.017) compared to the G allele homozygotes, especially for the healthy subjects in the left hemisphere. These results suggest a possible role for the YWHAE genotype in the early development of the OFC sulcogyral pattern, but its effect alone is not likely to explain the altered sulcogyral pattern in schizophrenia.
AB - An altered sulcogyral pattern in the orbitofrontal cortex (OFC) has been implicated in schizophrenia as a possible marker of abnormal neurodevelopment, while its genetic mechanism remains unknown. This magnetic resonance imaging study investigated the relationship between the polymorphism of YWHAE (rs28365859), a gene encoding 14-3-3epsilon that is a Disrupted-in-Schizophrenia 1 (DISC1)-interacting molecule associated with neuronal development, and the OFC subtypes of the 'H-shaped' sulcus (Types I, II, and III) in a Japanese sample of 72 schizophrenia patients and 86 healthy controls. The schizophrenia patients had significantly increased Type III (p=0.004) and decreased Type I (p=0.013) expression on the right hemisphere compared to the controls. The subjects carrying the protective C allele showed a decrease in Type III (p=0.005) and an increase in Type I (p=0.017) compared to the G allele homozygotes, especially for the healthy subjects in the left hemisphere. These results suggest a possible role for the YWHAE genotype in the early development of the OFC sulcogyral pattern, but its effect alone is not likely to explain the altered sulcogyral pattern in schizophrenia.
UR - http://www.scopus.com/inward/record.url?scp=84896889047&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84896889047&partnerID=8YFLogxK
U2 - 10.1016/j.pnpbp.2014.02.005
DO - 10.1016/j.pnpbp.2014.02.005
M3 - Article
C2 - 24561237
AN - SCOPUS:84896889047
SN - 0278-5846
VL - 51
SP - 166
EP - 171
JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry
JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry
ER -