The presence of late potentials after percutaneous coronary intervention for the treatment of acute coronary syndrome as a predictor for future significant cardiac events resulting in re-hospitalization

Mari Amino, Koichiro Yoshioka, Tomohide Ichikawa, Eiichi Watanabe, Ken Kiyono, Mari Nakamura, Susumu Sakama, Kengo Ayabe, Toshiharu Fujii, Tadashi Hashida, Shigetaka Kanda, Teruhisa Tanabe, Yuji Ikari

Research output: Contribution to journalArticle

Abstract

Introduction: We previously reported that LP positive patients after percutaneous coronary intervention (PCI) had higher rate of re-hospitalization in the small-scale study (135 patients). In this study, we evaluated correlation between LP and later cardiac events leading to re-hospitalization more extensively in greater population. Methods and results: A 24-h high-resolution (HR) ambulatory electrocardiogram (ECG) was performed in 421 patients that received PCI for the treatment of acute coronary syndrome (ACS) within 30 days. Various baseline characteristics and post-PCI ECG parameters including LP were examined for correlation with later re-hospitalization. LP was evaluated based on 3 different conditions, i.e., the worst, mean and best values, from 24-h signal-averaged QRS wave data. During the post-PCI follow-up period (611 ± 489.0 days), 90 patients were re-hospitalized due to cardiac events. Multivariate analysis identified only positive LP based on the worst value as an independent predictor for re-hospitalization with OR 2.26. Most of re-hospitalization cases (>75%) were predominantly attributed to ischemic events. LP positive population had significantly higher incidences of ischemic events as well as overall re-hospitalization compared to LP negative population. The predictive power of LP was decreased when it was combined with other variables. The receiver operating characteristic analysis determined the LP cut-off values consistent with the LP positive criteria previously reported and standardized. Conclusion: The presence of LP in the 24-h HR ambulatory ECG post-PCI was an independent predictor for a risk of re-hospitalization due to ischemic cardiac events in ACS patients.

Original languageEnglish
Pages (from-to)71-78
Number of pages8
JournalJournal of Electrocardiology
Volume53
DOIs
Publication statusPublished - 01-03-2019

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Percutaneous Coronary Intervention
Acute Coronary Syndrome
Hospitalization
Electrocardiography
Therapeutics
Population
ROC Curve
Multivariate Analysis
Incidence

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Amino, Mari ; Yoshioka, Koichiro ; Ichikawa, Tomohide ; Watanabe, Eiichi ; Kiyono, Ken ; Nakamura, Mari ; Sakama, Susumu ; Ayabe, Kengo ; Fujii, Toshiharu ; Hashida, Tadashi ; Kanda, Shigetaka ; Tanabe, Teruhisa ; Ikari, Yuji. / The presence of late potentials after percutaneous coronary intervention for the treatment of acute coronary syndrome as a predictor for future significant cardiac events resulting in re-hospitalization. In: Journal of Electrocardiology. 2019 ; Vol. 53. pp. 71-78.
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The presence of late potentials after percutaneous coronary intervention for the treatment of acute coronary syndrome as a predictor for future significant cardiac events resulting in re-hospitalization. / Amino, Mari; Yoshioka, Koichiro; Ichikawa, Tomohide; Watanabe, Eiichi; Kiyono, Ken; Nakamura, Mari; Sakama, Susumu; Ayabe, Kengo; Fujii, Toshiharu; Hashida, Tadashi; Kanda, Shigetaka; Tanabe, Teruhisa; Ikari, Yuji.

In: Journal of Electrocardiology, Vol. 53, 01.03.2019, p. 71-78.

Research output: Contribution to journalArticle

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T1 - The presence of late potentials after percutaneous coronary intervention for the treatment of acute coronary syndrome as a predictor for future significant cardiac events resulting in re-hospitalization

AU - Amino, Mari

AU - Yoshioka, Koichiro

AU - Ichikawa, Tomohide

AU - Watanabe, Eiichi

AU - Kiyono, Ken

AU - Nakamura, Mari

AU - Sakama, Susumu

AU - Ayabe, Kengo

AU - Fujii, Toshiharu

AU - Hashida, Tadashi

AU - Kanda, Shigetaka

AU - Tanabe, Teruhisa

AU - Ikari, Yuji

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N2 - Introduction: We previously reported that LP positive patients after percutaneous coronary intervention (PCI) had higher rate of re-hospitalization in the small-scale study (135 patients). In this study, we evaluated correlation between LP and later cardiac events leading to re-hospitalization more extensively in greater population. Methods and results: A 24-h high-resolution (HR) ambulatory electrocardiogram (ECG) was performed in 421 patients that received PCI for the treatment of acute coronary syndrome (ACS) within 30 days. Various baseline characteristics and post-PCI ECG parameters including LP were examined for correlation with later re-hospitalization. LP was evaluated based on 3 different conditions, i.e., the worst, mean and best values, from 24-h signal-averaged QRS wave data. During the post-PCI follow-up period (611 ± 489.0 days), 90 patients were re-hospitalized due to cardiac events. Multivariate analysis identified only positive LP based on the worst value as an independent predictor for re-hospitalization with OR 2.26. Most of re-hospitalization cases (>75%) were predominantly attributed to ischemic events. LP positive population had significantly higher incidences of ischemic events as well as overall re-hospitalization compared to LP negative population. The predictive power of LP was decreased when it was combined with other variables. The receiver operating characteristic analysis determined the LP cut-off values consistent with the LP positive criteria previously reported and standardized. Conclusion: The presence of LP in the 24-h HR ambulatory ECG post-PCI was an independent predictor for a risk of re-hospitalization due to ischemic cardiac events in ACS patients.

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