The prevalence of pseudoexfoliation syndrome in a Japanese population

The hisayama study

Miho Miyazaki, Toshiaki Kubota, Michiaki Kubo, Yutaka Kiyohara, Mituo Iida, Yoshiaki Nose, Tatsuro Ishibashi

Research output: Contribution to journalArticle

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Abstract

Purpose: To examine the prevalence and systemic associations of pseudoexfoliation syndrome (PXS) in a Japanese population. Methods: In 1998, a cross-sectional population-based survey was conducted among residents of Hisayama. Of a total of 3054 residents living in Hisayama, Japan, aged 50 years or older, 1844 consented to participate in the study. Each participant underwent a comprehensive examination that included an ophthalmic examination. The presence of any pseudoexfoliation material on the iris or lens capsule was determined by slit-lamp examination. The participants were classified as having pseudoexfoliation syndrome if any pseudoexfoliation material was present in either eye. Using these cross-sectional data, logistic regression analyses were performed to determine the systemic associations of pseudoexfoliation syndrome. The following eight possible correlates were considered: age, sex, hypertension, diabetes, hyperlipidemia, current smoker, alcohol intake, and body mass index. Results: Among the subjects, 50 (3.4%) had pseudoexfoliation syndrome. The prevalence of pseudoexfoliation syndrome increased significantly with age. Multiple logistic regression analysis showed that age and hypertension were significantly associated with pseudoexfoliation syndrome. Conclusion: The prevalence of pseudoexfoliation syndrome in a Japanese population was 3.4%, and increased with age. This study suggests that hypertension strongly correlates with pseudoexfoliation syndrome in our population-based sample of Japanese subjects aged 50 years or older.

Original languageEnglish
Pages (from-to)482-484
Number of pages3
JournalJournal of Glaucoma
Volume14
Issue number6
DOIs
Publication statusPublished - 01-12-2005
Externally publishedYes

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Exfoliation Syndrome
Population
Hypertension
Logistic Models
Regression Analysis
Iris
Hyperlipidemias
Lenses
Capsules
Japan
Body Mass Index
Alcohols

All Science Journal Classification (ASJC) codes

  • Ophthalmology

Cite this

Miyazaki, Miho ; Kubota, Toshiaki ; Kubo, Michiaki ; Kiyohara, Yutaka ; Iida, Mituo ; Nose, Yoshiaki ; Ishibashi, Tatsuro. / The prevalence of pseudoexfoliation syndrome in a Japanese population : The hisayama study. In: Journal of Glaucoma. 2005 ; Vol. 14, No. 6. pp. 482-484.
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The prevalence of pseudoexfoliation syndrome in a Japanese population : The hisayama study. / Miyazaki, Miho; Kubota, Toshiaki; Kubo, Michiaki; Kiyohara, Yutaka; Iida, Mituo; Nose, Yoshiaki; Ishibashi, Tatsuro.

In: Journal of Glaucoma, Vol. 14, No. 6, 01.12.2005, p. 482-484.

Research output: Contribution to journalArticle

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AU - Miyazaki, Miho

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N2 - Purpose: To examine the prevalence and systemic associations of pseudoexfoliation syndrome (PXS) in a Japanese population. Methods: In 1998, a cross-sectional population-based survey was conducted among residents of Hisayama. Of a total of 3054 residents living in Hisayama, Japan, aged 50 years or older, 1844 consented to participate in the study. Each participant underwent a comprehensive examination that included an ophthalmic examination. The presence of any pseudoexfoliation material on the iris or lens capsule was determined by slit-lamp examination. The participants were classified as having pseudoexfoliation syndrome if any pseudoexfoliation material was present in either eye. Using these cross-sectional data, logistic regression analyses were performed to determine the systemic associations of pseudoexfoliation syndrome. The following eight possible correlates were considered: age, sex, hypertension, diabetes, hyperlipidemia, current smoker, alcohol intake, and body mass index. Results: Among the subjects, 50 (3.4%) had pseudoexfoliation syndrome. The prevalence of pseudoexfoliation syndrome increased significantly with age. Multiple logistic regression analysis showed that age and hypertension were significantly associated with pseudoexfoliation syndrome. Conclusion: The prevalence of pseudoexfoliation syndrome in a Japanese population was 3.4%, and increased with age. This study suggests that hypertension strongly correlates with pseudoexfoliation syndrome in our population-based sample of Japanese subjects aged 50 years or older.

AB - Purpose: To examine the prevalence and systemic associations of pseudoexfoliation syndrome (PXS) in a Japanese population. Methods: In 1998, a cross-sectional population-based survey was conducted among residents of Hisayama. Of a total of 3054 residents living in Hisayama, Japan, aged 50 years or older, 1844 consented to participate in the study. Each participant underwent a comprehensive examination that included an ophthalmic examination. The presence of any pseudoexfoliation material on the iris or lens capsule was determined by slit-lamp examination. The participants were classified as having pseudoexfoliation syndrome if any pseudoexfoliation material was present in either eye. Using these cross-sectional data, logistic regression analyses were performed to determine the systemic associations of pseudoexfoliation syndrome. The following eight possible correlates were considered: age, sex, hypertension, diabetes, hyperlipidemia, current smoker, alcohol intake, and body mass index. Results: Among the subjects, 50 (3.4%) had pseudoexfoliation syndrome. The prevalence of pseudoexfoliation syndrome increased significantly with age. Multiple logistic regression analysis showed that age and hypertension were significantly associated with pseudoexfoliation syndrome. Conclusion: The prevalence of pseudoexfoliation syndrome in a Japanese population was 3.4%, and increased with age. This study suggests that hypertension strongly correlates with pseudoexfoliation syndrome in our population-based sample of Japanese subjects aged 50 years or older.

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