The prognostic significance of peritumoral lymphocytes' band-like structure in type II endometrial cancer

YUSUKE SHIMIZU; SHIRO SUZUKI; MAYU UKAI; SATOMI HATTORI; NOBUHISA YOSHIKAWA; HIROAKI KAJIYAMA

doi:10.21873/anticanres.14771

The prognostic significance of peritumoral lymphocytes' band-like structure in type II endometrial cancer

YUSUKE SHIMIZU, SHIRO SUZUKI, MAYU UKAI, SATOMI HATTORI, NOBUHISA YOSHIKAWA, HIROAKI KAJIYAMA

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Background/Aim: Peritumoral ectopic lymphoidlike structures and tertiary lymphoid structures (TLS), have been identified in various cancers. However, evidence for the role of TLS in endometrial cancer (EC) is lacking. We found a cluster of peritumoral lymphocytes with band-like structures (PLB) in the forefront of EC and analyzed their association with the clinical outcome. Materials and Methods: This was a single-center, retrospective cohort study. We evaluated peritumoral lymphoid cells using conventional hematoxylineosin and immunohistochemical staining by semi-quantitative digital analysis. Results: A total of 85 cases were included and the presence of PLB was examined. A strong correlation was observed between the density of PLB and progression-free survival (very low, low vs. intermediate, high; HR=0.22; 95%CI=0.093-0.52; p<0.001) and overall survival (very low, low vs. intermediate, high; HR=0.259; 95%CI=0.091-0.73; p=0.011). Conclusion: PLB in type II EC show a strong association with fatal outcome.

Original language	English
Pages (from-to)	249-258
Number of pages	10
Journal	Anticancer research
Volume	41
Issue number	1
DOIs	https://doi.org/10.21873/anticanres.14771
Publication status	Published - 01-2021
Externally published	Yes

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.21873/anticanres.14771

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title = "The prognostic significance of peritumoral lymphocytes' band-like structure in type II endometrial cancer",

abstract = "Background/Aim: Peritumoral ectopic lymphoidlike structures and tertiary lymphoid structures (TLS), have been identified in various cancers. However, evidence for the role of TLS in endometrial cancer (EC) is lacking. We found a cluster of peritumoral lymphocytes with band-like structures (PLB) in the forefront of EC and analyzed their association with the clinical outcome. Materials and Methods: This was a single-center, retrospective cohort study. We evaluated peritumoral lymphoid cells using conventional hematoxylineosin and immunohistochemical staining by semi-quantitative digital analysis. Results: A total of 85 cases were included and the presence of PLB was examined. A strong correlation was observed between the density of PLB and progression-free survival (very low, low vs. intermediate, high; HR=0.22; 95%CI=0.093-0.52; p<0.001) and overall survival (very low, low vs. intermediate, high; HR=0.259; 95%CI=0.091-0.73; p=0.011). Conclusion: PLB in type II EC show a strong association with fatal outcome.",

keywords = "Endometrial cancer, Peritumoral immune microenvironment, Prognosis, Tertiary lymphoid structure, Type II",

author = "YUSUKE SHIMIZU and SHIRO SUZUKI and MAYU UKAI and SATOMI HATTORI and NOBUHISA YOSHIKAWA and HIROAKI KAJIYAMA",

year = "2021",

month = jan,

doi = "10.21873/anticanres.14771",

language = "English",

volume = "41",

pages = "249--258",

journal = "Anticancer research",

issn = "0250-7005",

publisher = "International Institute of Anticancer Research",

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T1 - The prognostic significance of peritumoral lymphocytes' band-like structure in type II endometrial cancer

AU - SHIMIZU, YUSUKE

AU - SUZUKI, SHIRO

AU - UKAI, MAYU

AU - HATTORI, SATOMI

AU - YOSHIKAWA, NOBUHISA

AU - KAJIYAMA, HIROAKI

PY - 2021/1

Y1 - 2021/1

N2 - Background/Aim: Peritumoral ectopic lymphoidlike structures and tertiary lymphoid structures (TLS), have been identified in various cancers. However, evidence for the role of TLS in endometrial cancer (EC) is lacking. We found a cluster of peritumoral lymphocytes with band-like structures (PLB) in the forefront of EC and analyzed their association with the clinical outcome. Materials and Methods: This was a single-center, retrospective cohort study. We evaluated peritumoral lymphoid cells using conventional hematoxylineosin and immunohistochemical staining by semi-quantitative digital analysis. Results: A total of 85 cases were included and the presence of PLB was examined. A strong correlation was observed between the density of PLB and progression-free survival (very low, low vs. intermediate, high; HR=0.22; 95%CI=0.093-0.52; p<0.001) and overall survival (very low, low vs. intermediate, high; HR=0.259; 95%CI=0.091-0.73; p=0.011). Conclusion: PLB in type II EC show a strong association with fatal outcome.

AB - Background/Aim: Peritumoral ectopic lymphoidlike structures and tertiary lymphoid structures (TLS), have been identified in various cancers. However, evidence for the role of TLS in endometrial cancer (EC) is lacking. We found a cluster of peritumoral lymphocytes with band-like structures (PLB) in the forefront of EC and analyzed their association with the clinical outcome. Materials and Methods: This was a single-center, retrospective cohort study. We evaluated peritumoral lymphoid cells using conventional hematoxylineosin and immunohistochemical staining by semi-quantitative digital analysis. Results: A total of 85 cases were included and the presence of PLB was examined. A strong correlation was observed between the density of PLB and progression-free survival (very low, low vs. intermediate, high; HR=0.22; 95%CI=0.093-0.52; p<0.001) and overall survival (very low, low vs. intermediate, high; HR=0.259; 95%CI=0.091-0.73; p=0.011). Conclusion: PLB in type II EC show a strong association with fatal outcome.

KW - Endometrial cancer

KW - Peritumoral immune microenvironment

KW - Prognosis

KW - Tertiary lymphoid structure

KW - Type II

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The prognostic significance of peritumoral lymphocytes' band-like structure in type II endometrial cancer

Abstract

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