The prognostic significance of RCAS1 expression in squamous cell carcinoma of the oesophagus

Yoshihiro Nakakubo; Yasuhiro Hida; Masaki Miyamoto; Hideaki Hashida; Taro Oshikiri; Kentaro Kato; Masato Suzuoki; Kei Hiraoka; Tomoo Ito; Toshiaki Morikawa; Shunichi Okushiba; Satoshi Kondo; Hiroyuki Katoh

doi:10.1016/S0304-3835(01)00773-X

The prognostic significance of RCAS1 expression in squamous cell carcinoma of the oesophagus

Yoshihiro Nakakubo
, Yasuhiro Hida
, Masaki Miyamoto
, Hideaki Hashida
, Taro Oshikiri
, Kentaro Kato
, Masato Suzuoki
, Kei Hiraoka
, Tomoo Ito
, Toshiaki Morikawa
, Shunichi Okushiba
, Satoshi Kondo
, Hiroyuki Katoh

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

Overexpression of RCAS1 (receptor-binding cancer antigen expressed on SiSo cells) protects cancer cells from immune attack and might be related to poor prognosis in several cancers. We investigated the immunoreactivity of RCAS1 and its correlation with clinicopathological features in 95 patients who underwent surgical resection for oesophageal squamous cell carcinoma. Thirty-two of the 95 (33.7%) cases were strongly positive for RCAS1. RCAS1 showed significant correlations with age and stage grouping. Expression of RCAS1 was associated with shorter postoperative survival. Multivariate analysis indicated that RCAS1 positivity was an independent negative prognostic factor. Our study establishes RCAS1 as a novel prognostic marker for surgically resected oesophageal squamous cell carcinoma.

Original language	English
Pages (from-to)	101-105
Number of pages	5
Journal	Cancer Letters
Volume	177
Issue number	1
DOIs	https://doi.org/10.1016/S0304-3835(01)00773-X
Publication status	Published - 08-03-2002
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

Access to Document

10.1016/S0304-3835(01)00773-X

Cite this

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title = "The prognostic significance of RCAS1 expression in squamous cell carcinoma of the oesophagus",

abstract = "Overexpression of RCAS1 (receptor-binding cancer antigen expressed on SiSo cells) protects cancer cells from immune attack and might be related to poor prognosis in several cancers. We investigated the immunoreactivity of RCAS1 and its correlation with clinicopathological features in 95 patients who underwent surgical resection for oesophageal squamous cell carcinoma. Thirty-two of the 95 (33.7\%) cases were strongly positive for RCAS1. RCAS1 showed significant correlations with age and stage grouping. Expression of RCAS1 was associated with shorter postoperative survival. Multivariate analysis indicated that RCAS1 positivity was an independent negative prognostic factor. Our study establishes RCAS1 as a novel prognostic marker for surgically resected oesophageal squamous cell carcinoma.",

author = "Yoshihiro Nakakubo and Yasuhiro Hida and Masaki Miyamoto and Hideaki Hashida and Taro Oshikiri and Kentaro Kato and Masato Suzuoki and Kei Hiraoka and Tomoo Ito and Toshiaki Morikawa and Shunichi Okushiba and Satoshi Kondo and Hiroyuki Katoh",

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doi = "10.1016/S0304-3835(01)00773-X",

language = "English",

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TY - JOUR

T1 - The prognostic significance of RCAS1 expression in squamous cell carcinoma of the oesophagus

AU - Nakakubo, Yoshihiro

AU - Hida, Yasuhiro

AU - Miyamoto, Masaki

AU - Hashida, Hideaki

AU - Oshikiri, Taro

AU - Kato, Kentaro

AU - Suzuoki, Masato

AU - Hiraoka, Kei

AU - Ito, Tomoo

AU - Morikawa, Toshiaki

AU - Okushiba, Shunichi

AU - Kondo, Satoshi

AU - Katoh, Hiroyuki

PY - 2002/3/8

Y1 - 2002/3/8

N2 - Overexpression of RCAS1 (receptor-binding cancer antigen expressed on SiSo cells) protects cancer cells from immune attack and might be related to poor prognosis in several cancers. We investigated the immunoreactivity of RCAS1 and its correlation with clinicopathological features in 95 patients who underwent surgical resection for oesophageal squamous cell carcinoma. Thirty-two of the 95 (33.7%) cases were strongly positive for RCAS1. RCAS1 showed significant correlations with age and stage grouping. Expression of RCAS1 was associated with shorter postoperative survival. Multivariate analysis indicated that RCAS1 positivity was an independent negative prognostic factor. Our study establishes RCAS1 as a novel prognostic marker for surgically resected oesophageal squamous cell carcinoma.

AB - Overexpression of RCAS1 (receptor-binding cancer antigen expressed on SiSo cells) protects cancer cells from immune attack and might be related to poor prognosis in several cancers. We investigated the immunoreactivity of RCAS1 and its correlation with clinicopathological features in 95 patients who underwent surgical resection for oesophageal squamous cell carcinoma. Thirty-two of the 95 (33.7%) cases were strongly positive for RCAS1. RCAS1 showed significant correlations with age and stage grouping. Expression of RCAS1 was associated with shorter postoperative survival. Multivariate analysis indicated that RCAS1 positivity was an independent negative prognostic factor. Our study establishes RCAS1 as a novel prognostic marker for surgically resected oesophageal squamous cell carcinoma.

UR - https://www.scopus.com/pages/publications/18244388246

UR - https://www.scopus.com/pages/publications/18244388246#tab=citedBy

U2 - 10.1016/S0304-3835(01)00773-X

DO - 10.1016/S0304-3835(01)00773-X

M3 - Article

C2 - 11809537

AN - SCOPUS:18244388246

SN - 0304-3835

VL - 177

SP - 101

EP - 105

JO - Cancer Letters

JF - Cancer Letters

IS - 1

ER -

The prognostic significance of RCAS1 expression in squamous cell carcinoma of the oesophagus

Abstract

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All Science Journal Classification (ASJC) codes

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