The promoter of the classical MHC class I locus in rainbow trout (Oncorhynchus mykiss)

Johannes Martinus Dijkstra, Yasutoshi Yoshiura, Ikunari Kiryu, Kazuhiko Aoyagi, Bernd Köllner, Uwe Fischer, Teruyuki Nakanishi, Mitsuru Ototake

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

In rainbow trout only a single classical major histocompatibility complex (MHC) class I locus has been identified. In previous studies it was shown that this locus, Onmy-UBA, is characterised by extensive polymorphism and ubiquitous expression. In the present study the sequence of the promoter region of Onmy-UBA was analysed. Within this region several fragments for transcription regulation could be detected, including interferon-sensitive enhancer elements. The promoter region is very similar to that of classical MHC class I in higher vertebrates. In agreement with the interferon sensitive elements identified in its promoter, Onmy-UBA expression in rainbow trout gonad cells (RTG-2 cell line) was up-regulated after infection with infectious haematopoietic necrosis virus (IHNV).

Original languageEnglish
Pages (from-to)177-185
Number of pages9
JournalFish and Shellfish Immunology
Volume14
Issue number2
DOIs
Publication statusPublished - 01-01-2003

Fingerprint

major histocompatibility complex
Genetic Promoter Regions
Interferons
rainbow
Oncorhynchus mykiss
promoter regions
interferons
loci
Transcription
Polymorphism
Viruses
Infectious hematopoietic necrosis virus
enhancer elements
virus
vertebrate
polymorphism
Cells
gonads
transcription (genetics)
vertebrates

All Science Journal Classification (ASJC) codes

  • Environmental Chemistry
  • Aquatic Science

Cite this

Dijkstra, Johannes Martinus ; Yoshiura, Yasutoshi ; Kiryu, Ikunari ; Aoyagi, Kazuhiko ; Köllner, Bernd ; Fischer, Uwe ; Nakanishi, Teruyuki ; Ototake, Mitsuru. / The promoter of the classical MHC class I locus in rainbow trout (Oncorhynchus mykiss). In: Fish and Shellfish Immunology. 2003 ; Vol. 14, No. 2. pp. 177-185.
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Dijkstra, JM, Yoshiura, Y, Kiryu, I, Aoyagi, K, Köllner, B, Fischer, U, Nakanishi, T & Ototake, M 2003, 'The promoter of the classical MHC class I locus in rainbow trout (Oncorhynchus mykiss)', Fish and Shellfish Immunology, vol. 14, no. 2, pp. 177-185. https://doi.org/10.1006/fsim.2002.0431

The promoter of the classical MHC class I locus in rainbow trout (Oncorhynchus mykiss). / Dijkstra, Johannes Martinus; Yoshiura, Yasutoshi; Kiryu, Ikunari; Aoyagi, Kazuhiko; Köllner, Bernd; Fischer, Uwe; Nakanishi, Teruyuki; Ototake, Mitsuru.

In: Fish and Shellfish Immunology, Vol. 14, No. 2, 01.01.2003, p. 177-185.

Research output: Contribution to journalArticle

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