TY - JOUR
T1 - The relationship between body mass index and uric acid
T2 - a study on Japanese adult twins
AU - Tanaka, Kentaro
AU - Ogata, Soshiro
AU - Tanaka, Haruka
AU - Omura, Kayoko
AU - Honda, Chika
AU - Hayakawa, Kazuo
N1 - Funding Information:
Acknowledgments We would like to thank all the twin pair participants who were included in the study. This work was supported by University Grants from Japanese Ministry of Education, Culture, Sports, Science and Technology (MEXT) and MEXT KAKENHI Grant Number 262931510. Laboratory tests in this research were performed courtesy of Beckman Coulter, Inc.
Publisher Copyright:
© 2015, The Japanese Society for Hygiene.
PY - 2015/9/28
Y1 - 2015/9/28
N2 - Objectives: The present study aimed to investigate the association between body mass index (BMI) and uric acid (UA) using the twin study methodology to adjust for genetic factors. Methods: The association between BMI and UA was investigated in a cross-sectional study using data from both monozygotic and dizygotic twins registered at the Osaka University Center for Twin Research and the Osaka University Graduate School of Medicine. From January 2011 to March 2014, 422 individuals participated in the health examination. We measured height, weight, age, BMI, lifestyle habits (Breslow’s Health Practice Index), serum UA, and serum creatinine. To investigate the association between UA and BMI with adjustment for the clustering of a twin within a pair, individual-level analyses were performed using generalized linear mixed models (GLMMs). To investigate an association with adjustment for genetic and family environmental factors, twin-pair difference values analyses were performed. Results: In all analysis, BMI was associated with UA in men and women. Using the GLMMs, standardized regression coefficients were 0.194 (95 % confidence interval: 0.016–0.373) in men and 0.186 (95 % confidence interval: 0.071–0.302) in women. Considering twin-pair difference value analyses, standardized regression coefficients were 0.333 (95 % confidence interval: 0.072–0.594) in men and 0.314 (95 % confidence interval: 0.151–0.477) in women. Conclusions: The present study shows that BMI was significantly associated with UA, after adjusting for both genetic and familial environment factors in both men and women.
AB - Objectives: The present study aimed to investigate the association between body mass index (BMI) and uric acid (UA) using the twin study methodology to adjust for genetic factors. Methods: The association between BMI and UA was investigated in a cross-sectional study using data from both monozygotic and dizygotic twins registered at the Osaka University Center for Twin Research and the Osaka University Graduate School of Medicine. From January 2011 to March 2014, 422 individuals participated in the health examination. We measured height, weight, age, BMI, lifestyle habits (Breslow’s Health Practice Index), serum UA, and serum creatinine. To investigate the association between UA and BMI with adjustment for the clustering of a twin within a pair, individual-level analyses were performed using generalized linear mixed models (GLMMs). To investigate an association with adjustment for genetic and family environmental factors, twin-pair difference values analyses were performed. Results: In all analysis, BMI was associated with UA in men and women. Using the GLMMs, standardized regression coefficients were 0.194 (95 % confidence interval: 0.016–0.373) in men and 0.186 (95 % confidence interval: 0.071–0.302) in women. Considering twin-pair difference value analyses, standardized regression coefficients were 0.333 (95 % confidence interval: 0.072–0.594) in men and 0.314 (95 % confidence interval: 0.151–0.477) in women. Conclusions: The present study shows that BMI was significantly associated with UA, after adjusting for both genetic and familial environment factors in both men and women.
UR - http://www.scopus.com/inward/record.url?scp=84940461202&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84940461202&partnerID=8YFLogxK
U2 - 10.1007/s12199-015-0473-3
DO - 10.1007/s12199-015-0473-3
M3 - Article
C2 - 26037073
AN - SCOPUS:84940461202
VL - 20
SP - 347
EP - 353
JO - Environmental Health and Preventive Medicine
JF - Environmental Health and Preventive Medicine
SN - 1342-078X
IS - 5
ER -