The relationship between body mass index and uric acid: a study on Japanese adult twins

Kentaro Tanaka, Soshiro Ogata, Haruka Tanaka, Kayoko Omura, Chika Honda, Kazuo Hayakawa

Research output: Contribution to journalArticlepeer-review

42 Citations (Scopus)


Objectives: The present study aimed to investigate the association between body mass index (BMI) and uric acid (UA) using the twin study methodology to adjust for genetic factors. Methods: The association between BMI and UA was investigated in a cross-sectional study using data from both monozygotic and dizygotic twins registered at the Osaka University Center for Twin Research and the Osaka University Graduate School of Medicine. From January 2011 to March 2014, 422 individuals participated in the health examination. We measured height, weight, age, BMI, lifestyle habits (Breslow’s Health Practice Index), serum UA, and serum creatinine. To investigate the association between UA and BMI with adjustment for the clustering of a twin within a pair, individual-level analyses were performed using generalized linear mixed models (GLMMs). To investigate an association with adjustment for genetic and family environmental factors, twin-pair difference values analyses were performed. Results: In all analysis, BMI was associated with UA in men and women. Using the GLMMs, standardized regression coefficients were 0.194 (95 % confidence interval: 0.016–0.373) in men and 0.186 (95 % confidence interval: 0.071–0.302) in women. Considering twin-pair difference value analyses, standardized regression coefficients were 0.333 (95 % confidence interval: 0.072–0.594) in men and 0.314 (95 % confidence interval: 0.151–0.477) in women. Conclusions: The present study shows that BMI was significantly associated with UA, after adjusting for both genetic and familial environment factors in both men and women.

Original languageEnglish
Pages (from-to)347-353
Number of pages7
JournalEnvironmental Health and Preventive Medicine
Issue number5
Publication statusPublished - 28-09-2015
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health


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