The reversal effect of antidepressants on the escape deficit induced by inescapable shock in rats

Hideki Kametani, Soichiro Nomura, Jun Shimizu

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)

Abstract

This experiment investigated the effect of antidepressants on the escape deficit induced by inescapable shock. Following exposure te escapable shock, rats received a single injection of either tricyclic antidepressants (imipramine, desipramine), and atypical antidepressant (nomifensine), or saline. In a subsequent two-way shuttle test, treatments with these antidepressants reversed the escape deficit of the "inescapable-shock" groups without affecting performance of the "escapable-shock" groups. It is suggested that catecholamine re-uptake inhibition of the acute actions of antidepressants contributed to this reversal effect. The findings are discussed in relation to the neurochemical hypothesis of the escape deficit induced by inescapable shock and to an animal model of depression.

Original languageEnglish
Pages (from-to)206-208
Number of pages3
JournalPsychopharmacology
Volume80
Issue number3
DOIs
Publication statusPublished - 06-1983

All Science Journal Classification (ASJC) codes

  • Pharmacology

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