The risk factors of severe acute kidney injury induced by cisplatin

Tomohiro Mizuno, Kazuhiro Ishikawa, Waichi Sato, Takahiro Koike, Mayu Kushida, Yasuhiro Miyagawa, Kiyofumi Yamada, Sumio Hirata, Enyu Imai, Yukihiro Noda

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24 Citations (Scopus)

Abstract

Objectives: We reported that the KDIGO (Kidney Disease: Improving Global Outcomes) criteria could stratify the risk of mortality in acute kidney injury (AKI) caused by cisplatin. The purpose of this study was to investigate risk factors of severe cisplatin-induced AKI (CIA). Methods: From January 2006 to December 2012, we identified Japanese cancer patients who were treated with cisplatin as a first-line chemotherapy at Nagoya University Hospital. Serum creatinine levels were used to define CIA. Results: We evaluated 1,721 patients treated with cisplatin. In multivariable analysis, cisplatin dosages/m2 [odds ratio (OR) 1.019] or diagnosis of cancer stage 4 (OR 1.797) were risk factors of moderate CIA. History of diabetes mellitus (OR 3.454), history of cardiovascular disease (OR 3.612) or diagnosis of cancer stage 4 (OR 2.610) were risk factors of severe CIA. Conclusions: Diabetes mellitus, cardiovascular disease and advanced cancer increased the risk of severe CIA. As severe CIA shortens the survival period, we should consider whether the use of cisplatin benefits these patients.

Original languageEnglish
Pages (from-to)364-369
Number of pages6
JournalOncology (Switzerland)
Volume85
Issue number6
DOIs
Publication statusPublished - 2013

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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    Mizuno, T., Ishikawa, K., Sato, W., Koike, T., Kushida, M., Miyagawa, Y., Yamada, K., Hirata, S., Imai, E., & Noda, Y. (2013). The risk factors of severe acute kidney injury induced by cisplatin. Oncology (Switzerland), 85(6), 364-369. https://doi.org/10.1159/000356587