Conclusion: APOBEC1 utilizes a complementing protein to select target mRNAs.
Significance: These data shed light on the selective regulation of APOBEC1 target genes.
Background: APOBEC1 stabilizes target mRNAs by suppressing nonsense- or AU-rich element-mediated decay; however, the mechanisms regulating target selection are unknown.
Results: In the presence of hnRNPQ isoform 6, APOBEC1 stabilizes interleukin-8 mRNA independently of APOBEC1 complementation factor.
All Science Journal Classification (ASJC) codes
- Molecular Biology
- Cell Biology