The RNA-editing Enzyme APOBEC1 Requires heterogeneous nuclear ribonucleoprotein Q Isoform 6 for efficient interaction with interleukin-8 mRNA

Yuko Shimizu; Hironori Nishitsuji; Hiroyuki Marusawa; Saneyuki Ujino; Hiroshi Takaku; Kunitada Shimotohno

doi:10.1074/jbc.M114.563221

The RNA-editing Enzyme APOBEC1 Requires heterogeneous nuclear ribonucleoprotein Q Isoform 6 for efficient interaction with interleukin-8 mRNA

Yuko Shimizu, Hironori Nishitsuji, Hiroyuki Marusawa, Saneyuki Ujino, Hiroshi Takaku, Kunitada Shimotohno

Virology and Parasitology

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Conclusion: APOBEC1 utilizes a complementing protein to select target mRNAs.

Significance: These data shed light on the selective regulation of APOBEC1 target genes.

Background: APOBEC1 stabilizes target mRNAs by suppressing nonsense- or AU-rich element-mediated decay; however, the mechanisms regulating target selection are unknown.

Results: In the presence of hnRNPQ isoform 6, APOBEC1 stabilizes interleukin-8 mRNA independently of APOBEC1 complementation factor.

Original language	English
Pages (from-to)	26226-26238
Number of pages	13
Journal	Journal of Biological Chemistry
Volume	289
Issue number	38
DOIs	https://doi.org/10.1074/jbc.M114.563221
Publication status	Published - 19-09-2014

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Biology
Cell Biology

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title = "The RNA-editing Enzyme APOBEC1 Requires heterogeneous nuclear ribonucleoprotein Q Isoform 6 for efficient interaction with interleukin-8 mRNA",

abstract = "Conclusion: APOBEC1 utilizes a complementing protein to select target mRNAs.Significance: These data shed light on the selective regulation of APOBEC1 target genes.Background: APOBEC1 stabilizes target mRNAs by suppressing nonsense- or AU-rich element-mediated decay; however, the mechanisms regulating target selection are unknown.Results: In the presence of hnRNPQ isoform 6, APOBEC1 stabilizes interleukin-8 mRNA independently of APOBEC1 complementation factor.",

author = "Yuko Shimizu and Hironori Nishitsuji and Hiroyuki Marusawa and Saneyuki Ujino and Hiroshi Takaku and Kunitada Shimotohno",

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The RNA-editing Enzyme APOBEC1 Requires heterogeneous nuclear ribonucleoprotein Q Isoform 6 for efficient interaction with interleukin-8 mRNA. / Shimizu, Yuko; Nishitsuji, Hironori; Marusawa, Hiroyuki; Ujino, Saneyuki; Takaku, Hiroshi; Shimotohno, Kunitada.

In: Journal of Biological Chemistry, Vol. 289, No. 38, 19.09.2014, p. 26226-26238.

Research output: Contribution to journal › Article › peer-review

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AU - Shimizu, Yuko

AU - Nishitsuji, Hironori

AU - Marusawa, Hiroyuki

AU - Ujino, Saneyuki

AU - Takaku, Hiroshi

AU - Shimotohno, Kunitada

PY - 2014/9/19

Y1 - 2014/9/19

N2 - Conclusion: APOBEC1 utilizes a complementing protein to select target mRNAs.Significance: These data shed light on the selective regulation of APOBEC1 target genes.Background: APOBEC1 stabilizes target mRNAs by suppressing nonsense- or AU-rich element-mediated decay; however, the mechanisms regulating target selection are unknown.Results: In the presence of hnRNPQ isoform 6, APOBEC1 stabilizes interleukin-8 mRNA independently of APOBEC1 complementation factor.

AB - Conclusion: APOBEC1 utilizes a complementing protein to select target mRNAs.Significance: These data shed light on the selective regulation of APOBEC1 target genes.Background: APOBEC1 stabilizes target mRNAs by suppressing nonsense- or AU-rich element-mediated decay; however, the mechanisms regulating target selection are unknown.Results: In the presence of hnRNPQ isoform 6, APOBEC1 stabilizes interleukin-8 mRNA independently of APOBEC1 complementation factor.

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