The RNA-editing Enzyme APOBEC1 Requires heterogeneous nuclear ribonucleoprotein Q Isoform 6 for efficient interaction with interleukin-8 mRNA

Yuko Shimizu, Hironori Nishitsuji, Hiroyuki Marusawa, Saneyuki Ujino, Hiroshi Takaku, Kunitada Shimotohno

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Conclusion: APOBEC1 utilizes a complementing protein to select target mRNAs.

Significance: These data shed light on the selective regulation of APOBEC1 target genes.

Background: APOBEC1 stabilizes target mRNAs by suppressing nonsense- or AU-rich element-mediated decay; however, the mechanisms regulating target selection are unknown.

Results: In the presence of hnRNPQ isoform 6, APOBEC1 stabilizes interleukin-8 mRNA independently of APOBEC1 complementation factor.

Original languageEnglish
Pages (from-to)26226-26238
Number of pages13
JournalJournal of Biological Chemistry
Volume289
Issue number38
DOIs
Publication statusPublished - 19-09-2014
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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