TY - JOUR
T1 - The RNA-editing Enzyme APOBEC1 Requires heterogeneous nuclear ribonucleoprotein Q Isoform 6 for efficient interaction with interleukin-8 mRNA
AU - Shimizu, Yuko
AU - Nishitsuji, Hironori
AU - Marusawa, Hiroyuki
AU - Ujino, Saneyuki
AU - Takaku, Hiroshi
AU - Shimotohno, Kunitada
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 2014/9/19
Y1 - 2014/9/19
N2 - Conclusion: APOBEC1 utilizes a complementing protein to select target mRNAs.Significance: These data shed light on the selective regulation of APOBEC1 target genes.Background: APOBEC1 stabilizes target mRNAs by suppressing nonsense- or AU-rich element-mediated decay; however, the mechanisms regulating target selection are unknown.Results: In the presence of hnRNPQ isoform 6, APOBEC1 stabilizes interleukin-8 mRNA independently of APOBEC1 complementation factor.
AB - Conclusion: APOBEC1 utilizes a complementing protein to select target mRNAs.Significance: These data shed light on the selective regulation of APOBEC1 target genes.Background: APOBEC1 stabilizes target mRNAs by suppressing nonsense- or AU-rich element-mediated decay; however, the mechanisms regulating target selection are unknown.Results: In the presence of hnRNPQ isoform 6, APOBEC1 stabilizes interleukin-8 mRNA independently of APOBEC1 complementation factor.
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U2 - 10.1074/jbc.M114.563221
DO - 10.1074/jbc.M114.563221
M3 - Article
C2 - 25100733
AN - SCOPUS:84907192457
VL - 289
SP - 26226
EP - 26238
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
SN - 0021-9258
IS - 38
ER -