The role of a molecule associated with drug dependence, shati/nat8l

Yoshiaki Miyamoto, Eriko Saika, Etsuro Hori, Noriyuki Iegaki, Yudai Ishikawa, Kazuyuki Sumi, Toshitaka Nabeshima, Shin Ichi Muramatsu, Hisao Nishijo, Kyosuke Uno, Atsumi Nitta

Research output: Contribution to journalReview article

Abstract

Various molecules are involved in drug addiction induced by drugs of abuse. Therefore, the mechanism of drug addiction is still not clear, and it has been a difficulty in the development of preventive and curative drugs for drug dependence. We tried to identify the molecules associated with drug dependence, and found three molecules including shati/nat8l. Recently, it has been demonstrated that the substrate for shati/nat8l is aspaltate and shati/nat8l biosynthesizes N-acetylaspartate, which exists abundantly in the mammalian brain. In this study, we investigated the physiological function of shati/nat8l and the role of shati/nat8l in drug dependence. The overexpression of shati/nat8l in the dorsal striatum of mice led to social abnormality and depression-like behavior, and worsened a part of the motor dysfunction induced by Ca 2+ channel agonist BAYK 8644. The overexpression of shati/nat8l in the nucleus accumbens of mice inhibited methamphetamine-induced behavioral and biochemical abnormalities. These findings suggest that the shati/nat8l-associated system could play a role in the regulation of mental activity and motor action, and be a new target in the development of therapeutic drugs for drug dependence.

Original languageEnglish
Pages (from-to)167-173
Number of pages7
JournalJapanese Journal of Neuropsychopharmacology
Volume33
Issue number4
Publication statusPublished - 01-08-2013
Externally publishedYes

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Substance-Related Disorders
Methamphetamine
Nucleus Accumbens
Street Drugs
Pharmaceutical Preparations
Motor Activity
Depression
Brain

All Science Journal Classification (ASJC) codes

  • Clinical Psychology
  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)

Cite this

Miyamoto, Y., Saika, E., Hori, E., Iegaki, N., Ishikawa, Y., Sumi, K., ... Nitta, A. (2013). The role of a molecule associated with drug dependence, shati/nat8l. Japanese Journal of Neuropsychopharmacology, 33(4), 167-173.
Miyamoto, Yoshiaki ; Saika, Eriko ; Hori, Etsuro ; Iegaki, Noriyuki ; Ishikawa, Yudai ; Sumi, Kazuyuki ; Nabeshima, Toshitaka ; Muramatsu, Shin Ichi ; Nishijo, Hisao ; Uno, Kyosuke ; Nitta, Atsumi. / The role of a molecule associated with drug dependence, shati/nat8l. In: Japanese Journal of Neuropsychopharmacology. 2013 ; Vol. 33, No. 4. pp. 167-173.
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Miyamoto, Y, Saika, E, Hori, E, Iegaki, N, Ishikawa, Y, Sumi, K, Nabeshima, T, Muramatsu, SI, Nishijo, H, Uno, K & Nitta, A 2013, 'The role of a molecule associated with drug dependence, shati/nat8l', Japanese Journal of Neuropsychopharmacology, vol. 33, no. 4, pp. 167-173.

The role of a molecule associated with drug dependence, shati/nat8l. / Miyamoto, Yoshiaki; Saika, Eriko; Hori, Etsuro; Iegaki, Noriyuki; Ishikawa, Yudai; Sumi, Kazuyuki; Nabeshima, Toshitaka; Muramatsu, Shin Ichi; Nishijo, Hisao; Uno, Kyosuke; Nitta, Atsumi.

In: Japanese Journal of Neuropsychopharmacology, Vol. 33, No. 4, 01.08.2013, p. 167-173.

Research output: Contribution to journalReview article

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AU - Miyamoto, Yoshiaki

AU - Saika, Eriko

AU - Hori, Etsuro

AU - Iegaki, Noriyuki

AU - Ishikawa, Yudai

AU - Sumi, Kazuyuki

AU - Nabeshima, Toshitaka

AU - Muramatsu, Shin Ichi

AU - Nishijo, Hisao

AU - Uno, Kyosuke

AU - Nitta, Atsumi

PY - 2013/8/1

Y1 - 2013/8/1

N2 - Various molecules are involved in drug addiction induced by drugs of abuse. Therefore, the mechanism of drug addiction is still not clear, and it has been a difficulty in the development of preventive and curative drugs for drug dependence. We tried to identify the molecules associated with drug dependence, and found three molecules including shati/nat8l. Recently, it has been demonstrated that the substrate for shati/nat8l is aspaltate and shati/nat8l biosynthesizes N-acetylaspartate, which exists abundantly in the mammalian brain. In this study, we investigated the physiological function of shati/nat8l and the role of shati/nat8l in drug dependence. The overexpression of shati/nat8l in the dorsal striatum of mice led to social abnormality and depression-like behavior, and worsened a part of the motor dysfunction induced by Ca 2+ channel agonist BAYK 8644. The overexpression of shati/nat8l in the nucleus accumbens of mice inhibited methamphetamine-induced behavioral and biochemical abnormalities. These findings suggest that the shati/nat8l-associated system could play a role in the regulation of mental activity and motor action, and be a new target in the development of therapeutic drugs for drug dependence.

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Miyamoto Y, Saika E, Hori E, Iegaki N, Ishikawa Y, Sumi K et al. The role of a molecule associated with drug dependence, shati/nat8l. Japanese Journal of Neuropsychopharmacology. 2013 Aug 1;33(4):167-173.