The role of a molecule associated with drug dependence, shati/nat8l

Yoshiaki Miyamoto, Eriko Saika, Etsuro Hori, Noriyuki Iegaki, Yudai Ishikawa, Kazuyuki Sumi, Toshitaka Nabeshima, Shin Ichi Muramatsu, Hisao Nishijo, Kyosuke Uno, Atsumi Nitta

Research output: Contribution to journalReview articlepeer-review

Abstract

Various molecules are involved in drug addiction induced by drugs of abuse. Therefore, the mechanism of drug addiction is still not clear, and it has been a difficulty in the development of preventive and curative drugs for drug dependence. We tried to identify the molecules associated with drug dependence, and found three molecules including shati/nat8l. Recently, it has been demonstrated that the substrate for shati/nat8l is aspaltate and shati/nat8l biosynthesizes N-acetylaspartate, which exists abundantly in the mammalian brain. In this study, we investigated the physiological function of shati/nat8l and the role of shati/nat8l in drug dependence. The overexpression of shati/nat8l in the dorsal striatum of mice led to social abnormality and depression-like behavior, and worsened a part of the motor dysfunction induced by Ca2+ channel agonist BAYK 8644. The overexpression of shati/nat8l in the nucleus accumbens of mice inhibited methamphetamine-induced behavioral and biochemical abnormalities. These findings suggest that the shati/nat8l-associated system could play a role in the regulation of mental activity and motor action, and be a new target in the development of therapeutic drugs for drug dependence.

Original languageEnglish
Pages (from-to)167-173
Number of pages7
JournalJapanese Journal of Neuropsychopharmacology
Volume33
Issue number4
Publication statusPublished - 01-08-2013
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Clinical Psychology
  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)

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